Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Darshan V. Trivedi"'
Autor:
Arjun S. Adhikari, Darshan V. Trivedi, Saswata S. Sarkar, Dan Song, Kristina B. Kooiker, Daniel Bernstein, James A. Spudich, Kathleen M. Ruppel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Hypertrophic cardiomyopathy (HCM) leads to hyper-contractility of the heart and is often caused by mutations in human β-cardiac myosin. Here authors show that four separate β-cardiac myosin mutations can modulate myosin activity by disrupting intra
Externí odkaz:
https://doaj.org/article/63d16de0a0bc403b814ee96f47af11ce
Autor:
Suman Nag, Darshan V Trivedi
Publikováno v:
eLife, Vol 10 (2021)
Since the discovery of muscle in the 19th century, myosins as molecular motors have been extensively studied. However, in the last decade, a new functional super-relaxed (SRX) state of myosin has been discovered, which has a 10-fold slower ATP turnov
Externí odkaz:
https://doaj.org/article/d6eaa4a308814dc99fe764bb8535b865
Autor:
Darshan V. Trivedi, Anastasia Karabina, Gustave Bergnes, Alice Racca, Heba Wander, Seongwon Jung, Nimisha Mittal, Tonnie Huijs, Stephanie Ouchida, Paul V. Ruijgrok, Dan Song, Sergio Wittlin, Partha Mukherjee, Arnish Chakraborty, Elizabeth A. Winzeler, Jeremy N. Burrows, Benoît Laleu, Annamma Spudich, Kathleen Ruppel, Koen Dechering, Suman Nag, James A. Spudich
Malaria is a devastating disease that resulted in an estimated 627,000 deaths in 2020. About 80% of those deaths were among children under the age of five. Our approach is to develop small molecule inhibitors against cytoskeletal targets that are vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5672824c873878f99323d334e22c7c46
https://doi.org/10.1101/2022.09.09.507317
https://doi.org/10.1101/2022.09.09.507317
Publikováno v:
Annu Rev Biochem
Myosins are among the most fascinating enzymes in biology. As extremely allosteric chemomechanical molecular machines, myosins are involved in myriad pivotal cellular functions and are frequently sites of mutations leading to disease phenotypes. Huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a479565072b11b6b431a4538e7dd57
https://doi.org/10.1146/annurev-biochem-011520-105234
https://doi.org/10.1146/annurev-biochem-011520-105234
Autor:
Shaik Naseer Pasha, Makenna M. Morck, Kathleen M. Ruppel, James A. Spudich, Arjun S. Adhikari, Darshan V. Trivedi, Saswata S. Sarkar
Publikováno v:
Science Advances
Hypertrophic cardiomyopathy–causing mutations disrupt a key regulatory off state of myosin in thick filaments.
Hypertrophic cardiomyopathy (HCM) mutations in β-cardiac myosin and myosin binding protein-C (MyBP-C) lead to hypercontractility of
Hypertrophic cardiomyopathy (HCM) mutations in β-cardiac myosin and myosin binding protein-C (MyBP-C) lead to hypercontractility of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd261efaae65ac556049e9d5020ce46
https://doi.org/10.1126/sciadv.aax0069
https://doi.org/10.1126/sciadv.aax0069
Autor:
Mate Gyimesi, Adam I. Horvath, Demeter Turos, Sharad Kumar Suthar, Mate Penzes, Louise Canon, Carlos Kikuti, Kathleen Ruppel, Darshan V. Trivedi, James A. Spudich, Anna Á. Rauscher, Mihaly Kovacs, Samuel Komoly, Anne M. Houdusse, Andras Malnasi-Csizmadia
Publikováno v:
Biophysical Journal. 121:291a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::070844fcd91093fec7502ee58b2f0260
https://doi.org/10.1016/j.bpj.2021.11.1291
https://doi.org/10.1016/j.bpj.2021.11.1291
Autor:
Darshan V. Trivedi, Kristina B. Kooiker, Kathleen M. Ruppel, Arjun S. Adhikari, Daniel Bernstein, Dan Song, James A. Spudich, Saswata S. Sarkar
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Hypertrophic cardiomyopathy (HCM) affects 1 in 500 people and leads to hyper-contractility of the heart. Nearly 40 percent of HCM-causing mutations are found in human β-cardiac myosin. Previous studies looking at the effect of HCM mutations on the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac15a8ba0875c28fe7a32ad343e3c9c
http://europepmc.org/articles/PMC6582153
http://europepmc.org/articles/PMC6582153
Autor:
Darshan V. Trivedi, Kathleen M. Ruppel, Saswata S. Sarkar, Makenna M. Morck, James A. Spudich, Shaik Naseer Pasha, Arjun S. Adhikari
Hypertrophic cardiomyopathy (HCM) mutations in ß-cardiac myosin and myosin binding protein-C (MyBP-C) cause hypercontractility of the heart. We show that hypercontractility caused by the HCM myosin mutation R663H cannot be explained by changes in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db63e839af668151d6e1fa800a85730d
https://doi.org/10.1101/543413
https://doi.org/10.1101/543413
Autor:
James A. Spudich, Saswata S. Sarkar, Arjun S. Adhikari, Dan Song, Darshan V. Trivedi, Kristina B. Kooiker, Daniel Bernstein, Kathleen M. Ruppel
Hypertrophic cardiomyopathy (HCM) affects 1 in 500 people and leads to hyper-contractility of the heart. Nearly 40 percent of HCM-causing mutations are found in human β-cardiac myosin. Previous studies looking at the effect of HCM mutations on the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c9e688f51ade308abe2d55a5d324b8
Autor:
Kathleen M. Ruppel, Saswata S. Sarkar, Darshan V. Trivedi, James A. Spudich, Makenna M. Morck, Neha Nandwani
Publikováno v:
Biophysical Journal. 118:435a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b2485beba2d367794a4407ed131e5b8
https://doi.org/10.1016/j.bpj.2019.11.2440
https://doi.org/10.1016/j.bpj.2019.11.2440