Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Darryle Darwin Schoepp"'
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 312:826-833
The highly selective metabotropic glutamate (mGlu)2/3 receptor agonist LY379268 [(-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate] completely suppresses rapid eye movement (REM) sleep and strongly depresses theta (6-10 Hz) and high-frequency (
Autor:
Juan Félix Espinosa, Ivan Collado, Darryle Darwin Schoepp, Ann E. Kingston, Bryan G. Johnson, Angel Mazon, Concepcion Pedregal, Jaime Blanco-Urgoiti, Rebecca A. Wright
Publikováno v:
Journal of Medicinal Chemistry. 45:3619-3629
The asymmetric synthesis and biological activity of (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine 7 and its epimer at the C3' center 6 are described. Compound 7 is a highly potent and selective agonist for group 2 metabotropric glutama
Autor:
Paul L. Ornstein, David Lodge, Macklin Brian Arnold, Darryle Darwin Schoepp, Joseph P. Tizzano, N. K. Allen, J. D. Leander
Publikováno v:
Journal of Medicinal Chemistry. 38:4885-4890
We report the synthesis and characterization of 6 (LY246492), which is a competitive N-methyl-D-aspartate (NMDA) and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propanoic acid (AMPA) receptor antagonist. Tetrazole-substituted amino acid 6 was prepared
Autor:
Darryle Darwin Schoepp, Buddy E. Cantrell, J. S. Gidda, Dennis M. Zimmerman, J. D. Leander, B G Johnson
Publikováno v:
Journal of Medicinal Chemistry. 37:2262-2265
Structure-activity relationship studies were pursued within N-substituted-trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines in an effort to discover a peripherally selective opioid antagonist with high activity following systemic administration. Alte
Autor:
David Lodge, Darryle Darwin Schoepp, Paul L. Ornstein, Macklin Brian Arnold, J. D. Leander, T. Elzey, Jonathan W. Paschal
Publikováno v:
ChemInform. 22
We have prepared a series of cis-4-(tetrazolylakyl)piperidine-2-carboxylic acids as potent and selective N-methyl-D-aspartic acid (NMDA) receptor antagonists. NMDA antagonists may prove to be useful therapeutic agents, for instance, as anticonvulsant
Autor:
J. S. Gidda, Buddy E. Cantrell, Darryle Darwin Schoepp, B G Johnson, Dennis M. Zimmerman, J. D. Leander
Publikováno v:
ChemInform. 25
Structure-activity relationship studies were pursued within N-substituted-trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines in an effort to discover a peripherally selective opioid antagonist with high activity following systemic administration. Alte
Autor:
David Lodge, Macklin Brian Arnold, Joseph P. Tizzano, J. D. Leander, Paul L. Ornstein, Darryle Darwin Schoepp, N. K. Allen
Publikováno v:
ChemInform. 27
We report the synthesis and characterization of 6 (LY246492), which is a competitive N-methyl-D-aspartate (NMDA) and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propanoic acid (AMPA) receptor antagonist. Tetrazole-substituted amino acid 6 was prepared
Autor:
Jonathan W. Paschal, Paul L. Ornstein, Macklin Brian Arnold, David Lodge, Darryle Darwin Schoepp, J. D. Leander, T. Elzey
Publikováno v:
Journal of Medicinal Chemistry. 34:90-97
We have prepared a series of cis-4-(tetrazolylakyl)piperidine-2-carboxylic acids as potent and selective N-methyl-D-aspartic acid (NMDA) receptor antagonists. NMDA antagonists may prove to be useful therapeutic agents, for instance, as anticonvulsant
Publikováno v:
The Glutamate Receptors ISBN: 9781588297921
The group II metabotropic glutamate (mGlu2 and mGlu3) receptors are among the minority of glutamate receptors that primarily inhibit synaptic transmission by coupling to Gio, inhibiting adenylate cyclase and potassium channels. Our understanding of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89f1999d0cfcbaa04c574e8ce3ca19c7
https://doi.org/10.1007/978-1-59745-055-3_11
https://doi.org/10.1007/978-1-59745-055-3_11
Autor:
Ivan Collado, Eric D. Moher, Joseph P. Tizzano, Concepcion Pedregal, David W. Hoard, T. Rosario Gonzalez, Jaime Blanco-Urgoiti, Rebecca A. Wright, Darryle Darwin Schoepp, Javier Pérez-Castells, Kelly I. Griffey, Alicia Marcos, Ana Belén Bueno, Ann E. Kingston, Bryan G. Johnson
Publikováno v:
Journal of medicinal chemistry. 47(2)
The asymmetric synthesis and biological activity of (2S,1‘S,2‘R,3‘R)-2-(2‘-carboxy-3‘-hydroxymethylcyclopropyl) glycine ((+)-3) is described. This novel C-3‘ substituted carboxy cyclopropyl glycine is a highly potent group 2 and group 3 m