Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Darryl P. Leong"'
Autor:
Darryl P. Leong, Mark Loeb, Prem K. Mony, Sumathy Rangarajan, Maha Mushtaha, Matthew S. Miller, Mary Dias, Sergey Yegorov, Mamatha V, Ozge Telci Caklili, Ahmet Temizhan, Andrzej Szuba, Marc Evans M. Abat, Nafiza Mat-Nasir, Maria Luz Diaz, Hamda Khansaheb, Patricio Lopez-Jaramillo, MyLinh Duong, Koon K. Teo, Paul Poirier, Gustavo Oliveira, Álvaro Avezum, Salim Yusuf
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTThere are limited data on individual risk factors for SARS-CoV-2 infection (including unrecognized infection). In this seroepidemiologic substudy of an ongoing prospective cohort study of community-dwelling adults, participants were thoroughl
Externí odkaz:
https://doaj.org/article/b38af68c771a415f81c3d47e8363a180
Autor:
Eric K.C. Wong, MD, Justin Y. Lee, BScPhm, MD, PhD, Justin Chow, MD, Patricia Power, BSc, MSc, Laura Jin, BSc, MSc, Darryl P. Leong, MBBS, MPH, M.Biostat, PhD, Lawrence Mbuagbaw, MD, MPH, PhD, Sabina Keen, MD, Haroon Yousuf, MD, MHSc, Christopher Patterson, MD, Sharon Straus, MD, MSc, Catherine Demers, MD, MSc
Publikováno v:
CJC Open, Vol 4, Iss 6, Pp 532-539 (2022)
Background: Thiamine supplementation may improve cardiac function in older adults with heart failure (HF). Our objectives were to determine the following: (i) the feasibility of conducting a large trial of thiamine supplementation in HF; and (ii) the
Externí odkaz:
https://doaj.org/article/17facefbb8ca4133a67d0a864d42dcd0
Autor:
Darryl P. Leong, Ali Zhang, Jessica A. Breznik, Rumi Clare, Angela Huynh, Maha Mushtaha, Sumathy Rangarajan, Hannah Stacey, Paul Y. Kim, Mark Loeb, Judah A. Denburg, Dominik Mertz, Zain Chagla, Ishac Nazy, Matthew S. Miller, Dawn M. E. Bowdish, MyLinh Duong
Publikováno v:
PLoS ONE, Vol 18, Iss 2 (2023)
Objectives The dosing interval of a primary vaccination series can significantly impact on vaccine immunogenicity and efficacy. The current study compared 3 dosing intervals for the primary vaccination series of the BNT162b2 mRNA COVID-19 vaccine, on
Externí odkaz:
https://doaj.org/article/4fc1c265f9a04df8ba17d4e5815ad6c6
Autor:
Muhammad Mustafa Alhussein, MD, Abir Mokbel, MD, MSc, Tammy Cosman, RN(EC), PhD, Nazanin Aghel, MD, Eric H. Yang, MD, Som D. Mukherjee, MD, Susan Dent, MD, Peter M. Ellis, MBBS, MMed, PhD, Sukhbinder Dhesy-Thind, MD, MSc, Darryl P. Leong, MBBS, MPH, M. Biostat, PhD
Publikováno v:
CJC Open, Vol 3, Iss 11, Pp 1372-1382 (2021)
Background: Human epidermal growth factor receptor 2 (HER2) overexpressing malignancies, including breast and gastro-esophageal, are associated with a poor prognosis. The cardiotoxicity of trastuzumab, a HER2-targeting monoclonal antibody, is well es
Externí odkaz:
https://doaj.org/article/19ebfb6c8fb04bf8886b70411a949d57
Autor:
Jose P. Lopez-Lopez, Daniel D. Cohen, Daniela Ney-Salazar, Daniel Martinez, Johanna Otero, Diego Gomez-Arbelaez, Paul A. Camacho, Gregorio Sanchez-Vallejo, Edgar Arcos, Claudia Narvaez, Henry Garcia, Maritza Perez, Dora I. Molina, Carlos Cure, Aristides Sotomayor, Álvaro Rico, Eric Hernandez-Triana, Myriam Duran, Fresia Cotes, Darryl P. Leong, Sumathy Rangarajan, Salim Yusuf, Patricio Lopez-Jaramillo
Publikováno v:
Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-11 (2021)
Abstract Background Adiposity is a major component of the metabolic syndrome (MetS), low muscle strength has also been identified as a risk factor for MetS and for cardiovascular disease. We describe the prevalence of MetS and evaluate the relationsh
Externí odkaz:
https://doaj.org/article/a4a3a322c41a4eadb37985730386c1c8
Autor:
Anthony R. Sandre, MSc, MD, Darryl P. Leong, MBBS, MPH, MBiostat, PhD, David Landry, MD, FRCPC, Leslie J. Martin, MHPE, MD, FRCPC
Publikováno v:
CJC Open, Vol 2, Iss 6, Pp 722-725 (2020)
Takotsubo syndrome is a well described clinical phenomenon that often mimics acute coronary syndrome. We present an atypical case of Takotsubo syndrome, characterized by delayed troponin elevation and electrocardiogram changes suggestive of acute cor
Externí odkaz:
https://doaj.org/article/05a7a7e882134669b2cb91930922369c
Autor:
Darryl P. Leong, MBBS, MPH, MBiostat, PhD, Tammy Cosman, PhD, Muhammad M. Alhussein, MD, Nidhi Kumar Tyagi, MBChB, Sarah Karampatos, MS, Carly C. Barron, MD, MS, Douglas Wright, MD, Vikas Tandon, MD, Patrick Magloire, MD, Philip Joseph, MD, David Conen, MD, MPH, P.J. Devereaux, MD, PhD, Peter M. Ellis, MBBS, MMed, PhD, Som D. Mukherjee, MD, MS, Sukhbinder Dhesy-Thind, MD, MS
Publikováno v:
JACC. CardioOncology, Vol 1, Iss 1, Pp 1-10 (2019)
Objectives: This study sought to evaluate the safety of continuing trastuzumab in patients with human epidermal growth factor receptor–positive breast cancer who developed mild cardiotoxicity. Background: Cardiotoxicity is the most common dose-limi
Externí odkaz:
https://doaj.org/article/853ece99bece43b0bf1ea0e673d30148
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 3 (2020)
Background Frailty is associated with higher mortality in individuals at high cardiovascular disease (CVD) risk. We hypothesize that frailty is a more important prognostic factor than CVD risk factors and aim to determine the prognostic value of a cu
Externí odkaz:
https://doaj.org/article/873d1114bda6432288646e3d75082147
Autor:
Eric Kai Chung Wong, Justin Yusen Lee, Darryl P. Leong, Lawrence Mbuagbaw, Haroon Yousuf, Sabina Keen, Sharon E. Straus, Christopher J. Patterson, Catherine Demers
Publikováno v:
Pilot and Feasibility Studies, Vol 4, Iss 1, Pp 1-7 (2018)
Abstract Background Heart failure (HF) is a major cardiovascular disease with increasing prevalence. Thiamine deficiency occurs in 33% of patients with HF. However, the effectiveness of thiamine supplementation in HF is not known. Methods In a placeb
Externí odkaz:
https://doaj.org/article/562f977ead334118a8355167634095e7
Autor:
Lili Aslostovar, Allison L. Boyd, Mohammed Almakadi, Tony J. Collins, Darryl P. Leong, Rommel G. Tirona, Richard B. Kim, Jim A. Julian, Anargyros Xenocostas, Brian Leber, Mark N. Levine, Ronan Foley, Mickie Bhatia
Publikováno v:
Blood Advances, Vol 2, Iss 15, Pp 1935-1945 (2018)
Abstract: We completed a phase 1 dose-escalation trial to evaluate the safety of a dopamine receptor D2 (DRD2) antagonist thioridazine (TDZ), in combination with cytarabine. Thirteen patients 55 years and older with relapsed or refractory acute myelo
Externí odkaz:
https://doaj.org/article/65462c7955b0444b8aa80b9a26bdee79