Výsledky vyhledávání - "Darryl Overby"

Akademický článek

Emergent Temporal Signaling in Human Trabecular Meshwork Cells: Role of TRPV4-TRPM4 Interactions

Autor: Oleg Yarishkin, Tam T. T. Phuong, Felix Vazquez-Chona, Jacques Bertrand, Joseph van Battenburg-Sherwood, Sarah N. Redmon, Christopher N. Rudzitis, Monika Lakk, Jackson M. Baumann, Marc Freichel, Eun-Mi Hwang, Darryl Overby, David Križaj

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Trabecular meshwork (TM) cells are phagocytic cells that employ mechanotransduction to actively regulate intraocular pressure. Similar to macrophages, they express scavenger receptors and participate in antigen presentation within the immunosuppressi

Externí odkaz: https://doaj.org/article/e878d86628904c698824107f4feebaa7

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Measurement of Postmortem Outflow Facility using iPerfusion

Autor: Ester Reina-Torres, Michael Madekurozwa, Joseph Van Batenburg-Sherwood, Darryl Overby

Publikováno v: Exp Eye Res

The key risk factor for glaucoma is elevation of intraocular pressure (IOP) and alleviating it is the only effective therapeutic approach to inhibit further vision loss. IOP is regulated by the flow of aqueous humour across resistive tissues, and a r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a0472b7cde9396abc4883e05407547
https://europepmc.org/articles/PMC9233154/

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TRPM4 is required for calcium oscillations downstream from the stretch-activated TRPV4 channel

Autor: Oleg Yarishkin, Tam T. T. Phuong, Felix Vazquez-Chona, Jacques Bertrand, Sarah N. Redmon, Monika Lakk, Christopher N. Rudzitis, Jackson M. Baumann, Eun Mi Hwang, Darryl Overby, David Križaj

Transduction of mechanical information is influenced by physical, chemical and thermal cues but the molecular mechanisms through which transducer activation shapes temporal signaling remain underexplored. In the present study, electrophysiology, hist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2c1436c235d401c52130e489784e386
https://doi.org/10.1101/2021.12.15.472700

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Segmental outflow dynamics in the trabecular meshwork of living mice

Autor: Tiffany MG Baptiste, Ester Reina-Torres, Darryl Overby

Publikováno v: Experimental Eye Research. 225:109285

Aqueous humour does not drain uniformly through the trabecular meshwork (TM), but rather follows non-uniform or "segmental" routes. In this study, we examined whether segmental outflow patterns in the TM change over time in living mice and whether su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af54b12cee753ec8548fb097ec32357
https://doi.org/10.1016/j.exer.2022.109285

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Tools to study cell mechanics and mechanotransduction

Autor: Tanmay P, Lele, Julia E, Sero, Benjamin D, Matthews, Sanjay, Kumar, Shannon, Xia, Martin, Montoya-Zavala, Thomas, Polte, Darryl, Overby, Ning, Wang, Donald E, Ingber

Publikováno v: Methods in cell biology. 83

Analysis of how cells sense and respond to mechanical stress has been limited by the availability of techniques that can apply controlled mechanical forces to living cells while simultaneously measuring changes in cell and molecular distortion, as we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7eb55d590acc74b7031b78a365ecd0e
https://pubmed.ncbi.nlm.nih.gov/17613320

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The mechanism of increasing outflow facility during washout in the bovine eye

Autor: Darryl, Overby, Haiyan, Gong, Guanting, Qiu, Thomas F, Freddo, Mark, Johnson

Publikováno v: Investigative ophthalmologyvisual science. 43(11)

To investigate the relationship between outflow facility and separation between the inner wall of the aqueous plexus and the juxtacanalicular connective tissue (JCT) during washout in the bovine eye.Facility was recorded during 3 hours of anterior ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::66cec062d067fb82b87c3f84109c5f94
https://pubmed.ncbi.nlm.nih.gov/12407156

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A new view of the human trabecular meshwork using quick-freeze, deep-etch electron microscopy

Autor: Haiyan, Gong, Jeffrey, Ruberti, Darryl, Overby, Mark, Johnson, Thomas F, Freddo

Publikováno v: Experimental eye research. 75(3)

Conventional transmission electron microscopic (TEM) images of the juxtacanalicular tissue (JCT) region of the trabecular meshwork (TM) show flow passages that are much too large to generate significant outflow resistance. The goal of the current stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b526fac07fd3ff6f30e462abf2780b7
https://pubmed.ncbi.nlm.nih.gov/12384097

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