Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Darryl McDougald"'
Autor:
Yutian Feng, Rebecca Meshaw, Darryl McDougald, Zhengyuan Zhou, Xiao-Guang Zhao, Stephen A. Jannetti, Robert E. Reiman, Erica Pippen, Robin Marjoram, Jeffrey L. Schaal, Ganesan Vaidyanathan, Michael R. Zalutsky
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Radiopharmaceutical therapy (RPT) is an attractive strategy for treatment of disseminated cancers including those overexpressing the HER2 receptor including breast, ovarian and gastroesophageal carcinomas. Single-domain antibody fragments (s
Externí odkaz:
https://doaj.org/article/d70520eee8e345729165a858843f0fb1
Autor:
Ganesan Vaidyanathan, Irina V. Balyasnikova, Darryl McDougald, Rebecca Meshaw, Michael R. Zalutsky, Zhengyuan Zhou
Publikováno v:
Nuclear Medicine and Biology. :24-35
Introduction Labeling single domain antibody fragments (sdAbs) with 18F is an attractive strategy for immunoPET. Earlier, we developed a residualizing label, N-succinimidyl 3-((4-(4-fluorobutyl)-1H-1,2,3-triazol-1-yl)methyl)-5-(guanidinomethyl)benzoa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e4790befb7a097211717b6324fc3c2e
https://doi.org/10.1016/j.nucmedbio.2021.06.002
https://doi.org/10.1016/j.nucmedbio.2021.06.002
Autor:
Daniele Procissi, Stephen A Jannetti, Markella Zannikou, Zhengyuan Zhou, Darryl McDougald, Deepak Kanojia, Hui Zhang, Kirsten Burdett, Ganesan Vaidyanathan, Michael R Zalutsky, Irina V Balyasnikova
Publikováno v:
Neuro-oncology advances. 4(1)
Background Single-domain antibody fragments (aka VHH, ~ 13 kDa) are promising delivery systems for brain tumor theranostics; however, achieving efficient delivery of VHH to intracranial lesions remains challenging due to the tumor–brain barrier. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905c0f1f7a12bc9fea831bd1c5553a13
https://pubmed.ncbi.nlm.nih.gov/36128586
https://pubmed.ncbi.nlm.nih.gov/36128586
Autor:
Daniele Procissi, Stephen A. Jannetti, Markella Zannikou, Zhengyuan Zhou, Darryl McDougald, Deepak Kanojia, Ganesan Vaidyanathan, Michael R. Zalutsky, Irina V. Balyasnikova
BackgroundSingle-domain antibody fragments (aka VHH, ∼13 kDa) are promising delivery systems for brain tumor theranostics; however, achieving efficient delivery of VHH to intracranial lesions remains challenging due to the tumor-brain barrier. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2f00cada561d093af234fed41ef7cb0
https://doi.org/10.1101/2022.04.19.488555
https://doi.org/10.1101/2022.04.19.488555
Autor:
Zhengyuan, Zhou, Darryl, McDougald, Rebecca, Meshaw, Irina, Balyasnikova, Michael R, Zalutsky, Ganesan, Vaidyanathan
Publikováno v:
Nucl Med Biol
INTRODUCTION: Labeling single domain antibody fragments (sdAbs) with (18)F is an attractive strategy for immunoPET. Earlier, we developed a residualizing label, N-succinimidyl 3-((4-(4-fluorobutyl)-1H-1,2,3-triazol-1-yl)methyl)-5-(guanidinomethyl)ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8093432c05e49118dbdc9929d10e3c61
https://pubmed.ncbi.nlm.nih.gov/34146837
https://pubmed.ncbi.nlm.nih.gov/34146837
Autor:
Ganesan Vaidyanathan, Jaeyeon Choi, Vivek Kumar, Michael R. Zalutsky, Ying Chen, Hassan Shallal, Ronnie C. Mease, Il Minn, Choong Mo Kang, Martin G. Pomper, Darryl McDougald
Introduction The high potency and short tissue range of α-particles are attractive features for targeted radionuclide therapy, particularly for cancers with micro-metastases. In the current study, we describe the synthesis of a series of 211At-label
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14315b79ab97e778997259b24cc8ec6f
https://doi.org/10.1016/j.nucmedbio.2021.01.002
https://doi.org/10.1016/j.nucmedbio.2021.01.002
Autor:
Ganesan, Vaidyanathan, Ronnie C, Mease, Il, Minn, Jaeyeon, Choi, Ying, Chen, Hassan, Shallal, Choong Mo, Kang, Darryl, McDougald, Vivek, Kumar, Martin G, Pomper, Michael R, Zalutsky
Publikováno v:
Nucl Med Biol
INTRODUCTION: The high potency and short tissue range of α-particles are attractive features for targeted radionuclide therapy, particularly for cancers with micro-metastases. In the current study, we describe the synthesis of a series of (211)At-la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7114f8851e3e5082a8032870edb5727f
https://pubmed.ncbi.nlm.nih.gov/33601187
https://pubmed.ncbi.nlm.nih.gov/33601187
Autor:
Rebecca Meshaw, Zhengyuan Zhou, Darryl McDougald, Yutian Feng, Michael R. Zalutsky, Ganesan Vaidyanathan
Publikováno v:
Nucl Med Biol
INTRODUCTION: As a consequence of their small size, high stability and high affinity, single domain antibody fragments (sdAb) are appealing targeting vectors for radiopharmaceutical development. With sdAbs binding to internalizing receptors like HER2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089f7da35fe68ce77c1e7feaed4399c1
https://pubmed.ncbi.nlm.nih.gov/32448731
https://pubmed.ncbi.nlm.nih.gov/32448731
ImmunoPET agents are being investigated to assess the status of epidermal growth factor receptor 2 (HER2) in breast cancer patients with the goal of selecting those likely to benefit from HER2-targeted therapies and monitoring their progress after th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2f989407ae177e29dec95e98f6bbdc
https://hdl.handle.net/20.500.14017/3515ccf3-ffc3-4717-ae70-6e8a4093047b
https://hdl.handle.net/20.500.14017/3515ccf3-ffc3-4717-ae70-6e8a4093047b
Autor:
Zhengyuan, Zhou, Darryl, McDougald, Nick, Devoogdt, Michael R, Zalutsky, Ganesan, Vaidyanathan
Publikováno v:
Molecular pharmaceutics. 16(1)
ImmunoPET agents are being investigated to assess the status of epidermal growth factor receptor 2 (HER2) in breast cancer patients with the goal of selecting those likely to benefit from HER2-targeted therapies and monitoring their progress after th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e15d904ca82b743d15ce94a6d926015
https://pubmed.ncbi.nlm.nih.gov/30427188
https://pubmed.ncbi.nlm.nih.gov/30427188