Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Darryl McConnell"'
Autor:
Nina Kerres, Steffen Steurer, Stefanie Schlager, Gerd Bader, Helmut Berger, Maureen Caligiuri, Christian Dank, John R. Engen, Peter Ettmayer, Bernhard Fischerauer, Gerlinde Flotzinger, Daniel Gerlach, Thomas Gerstberger, Teresa Gmaschitz, Peter Greb, Bingsong Han, Elizabeth Heyes, Roxana E. Iacob, Dirk Kessler, Heike Kölle, Lyne Lamarre, David R. Lancia, Simon Lucas, Moriz Mayer, Katharina Mayr, Nikolai Mischerikow, Katja Mück, Christoph Peinsipp, Oliver Petermann, Ulrich Reiser, Dorothea Rudolph, Klaus Rumpel, Carina Salomon, Dirk Scharn, Renate Schnitzer, Andreas Schrenk, Norbert Schweifer, Diane Thompson, Elisabeth Traxler, Roland Varecka, Tilman Voss, Alexander Weiss-Puxbaum, Sandra Winkler, Xiaozhang Zheng, Andreas Zoephel, Norbert Kraut, Darryl McConnell, Mark Pearson, Manfred Koegl
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2860-2875 (2017)
The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Disruption of its interaction with transcriptional repressors interferes with the oncogenic effects of BCL6. We
Externí odkaz:
https://doaj.org/article/43ac770ae3294c078849cf3143253f8a
Autor:
Andreas Gollner, Markus Köster, Paul Nicklin, Thomas Trieselmann, Elliott Klein, Jaromir Vlach, Claudia Heine, Marc Grundl, Jürgen Ramharter, David Wyatt, Menorca Chaturvedi, Alessio Ciulli, Katharine C. Carter, Susanne Müller, Daniel Bischoff, Peter Ettmayer, Eric Haaksma, Jürgen Mack, Darryl McConnell, Dirk Stenkamp, Harald Weinstabl, Matthias Zentgraf, Clive R. Wood, Florian Montel
Publikováno v:
Nature reviews. Drug discovery. 21(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0532092410ea682f9e1120d72a6dd5c
https://pubmed.ncbi.nlm.nih.gov/35459938
https://pubmed.ncbi.nlm.nih.gov/35459938
Publikováno v:
Synthesis. 2009:3661-3671
4,5-Dihydrobenzo[g]indazoles were efficiently metallated using hindered Mg- and Zn-TMP amides. Trapping of the resulting organometallic reagents with various electrophiles furnished novel C3-substituted 4,5-dihydrobenzo[g]indazoles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18b094502546134e0a04b185da0d00a5
https://doi.org/10.1055/s-0029-1217008
https://doi.org/10.1055/s-0029-1217008
Autor:
Angela Luttick, Rachel Cameron, Pauline C. Stanislawski, Guy Y. Krippner, Keith G. Watson, Darryl Mcconnell, Roland Henry Nearn, David K. Chalmers, Renee N. Brown, Stephanie Hamilton, Simon P. Tucker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2051-2055
A series of pyridazinylpiperidinyl capsid-binding compounds with novel bicyclic substituents were synthesized and screened against human rhinovirus (HRV). Several 2-alkoxy- and 2-alkylthio-benzoxazole and benzothiazole derivatives showed excellent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5369f251ed79b35feac0a2e835dce08c
https://doi.org/10.1016/j.bmcl.2005.02.054
https://doi.org/10.1016/j.bmcl.2005.02.054
Autor:
Simon J. F. Macdonald, David Gower, Andrew M. Mason, Stephanie Hamilton, Betty Jin, Guy Y. Krippner, Rob J. Fenton, Van N.B. Nguyen, Angela Luttick, Keith G. Watson, Simon P. Tucker, Rachel Cameron, Darryl Mcconnell, Wen-Yang Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1589-1592
A set of trimeric and tetrameric derivatives 6-11 of the influenza virus neuraminidase inhibitor zanamivir 1 have been synthesized by coupling a common monomeric zanamivir derivative 3 onto various multimeric carboxylic acid core groups. These discre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ba68e1e438b9128b66d7f2c4dfb03b
https://doi.org/10.1016/j.bmcl.2003.09.102
https://doi.org/10.1016/j.bmcl.2003.09.102
Autor:
Susanne C. Feil, Guy Y. Krippner, Pauline C. Stanislawski, Bo Lin, Stephanie Hamilton, Darryl Mcconnell, Simon P. Tucker, Michael W. Parker, Roland Henry Nearn, Keith G. Watson, Angela Luttick, Jane Ryan, Craig J. Morton
Respiratory infections caused by human rhinovirus are responsible for severe exacerbations of underlying clinical conditions such as asthma in addition to their economic cost in terms of lost working days due to illness. While several antiviral compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef31421d5b4c0daef04ce82c3af7c8d
https://europepmc.org/articles/PMC4025830/
https://europepmc.org/articles/PMC4025830/
Publikováno v:
ChemInform. 41
4,5-Dihydrobenzo[g]indazoles were efficiently metallated using hindered Mg- and Zn-TMP amides. Trapping of the resulting organometallic reagents with various electrophiles furnished novel C3-substituted 4,5-dihydrobenzo[g]indazoles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b9bae1d4e4e152f48ee27d8303be1d3
https://doi.org/10.1002/chin.201010125
https://doi.org/10.1002/chin.201010125
Autor:
Simon J. F. Macdonald, Alan P. Hill, Rob J. Fenton, Gail Mills, Stephanie Hamilton, David Gower, Wen-Yang Wu, Donna Smith, Van Loc Nguyen, Betty Jin, Stephen E. Shanahan, Haydn Terence Jones, Darryl Mcconnell, Graham Foster, Simon P. Tucker, Graham G. A. Inglis, J. Nicole Hamblin, Graham J Hart, Ian J. Owens, Derek A. Demaine, Jennifer McKimm-Breschkin, Rachel Cameron, Nigel R. Parry, Keith G. Watson
Publikováno v:
Journal of medicinal chemistry. 48(8)
The synthesis, antiviral and pharmacokinetic properties of zanamivir (ZMV) dimers 8 and 13 are described. The compounds are highly potent neuraminidase (NA) inhibitors which, along with dimer 3, are being investigated as potential second generation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61520fde8e6053e6074e2ce56edefd0
https://pubmed.ncbi.nlm.nih.gov/15828835
https://pubmed.ncbi.nlm.nih.gov/15828835
Autor:
Angela Luttick, Wen-Yang Wu, Betty Jin, Keith G. Watson, Stephanie Hamilton, Guy Y. Krippner, Dale L. Barnard, Jane Ryan, Rachel Cameron, Pauline C. Stanislawski, Robert W. Sidwell, Darryl Mcconnell, Simon P. Tucker, David K. Chalmers, Phillip A. Reece, Renee N. Brown
Publikováno v:
Monash University
A series of capsid-binding compounds was screened against human rhinovirus (HRV) using a CPE based assay. The ethyl oxime ether 14 was found to have outstanding anti-HRV activity (median IC(50) 4.75 ng/mL), and unlike the equivalent ethyl ester compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0111a648a3c12bdc6d17501f52a4151
https://research.monash.edu/en/publications/ff024c9d-8148-4f34-ba91-9a34408a2fed
https://research.monash.edu/en/publications/ff024c9d-8148-4f34-ba91-9a34408a2fed
Autor:
Donna Smith, David Gower, Andrew M. Mason, Phillip A. Reece, Rachel Cameron, Simon P. Tucker, Nigel R. Parry, Ian J. Owens, Darryl Mcconnell, Wen-Yang Wu, Graham G. A. Inglis, Van N.B. Nguyen, Stephen E. Shanahan, Keith G. Watson, J. Nicole Hamblin, David K. Chalmers, Betty Jin, Derek A. Demaine, Rob J. Fenton, Haydn Terence Jones, Graham J Hart, Simon J. F. Macdonald, Stephanie Hamilton
Publikováno v:
Monash University
Dimeric derivatives (compounds 7 to 9) of the influenza virus neuraminidase inhibitor zanamivir (compound 2), which have linking groups of 14 to 18 atoms in length, are approximately 100-fold more potent inhibitors of influenza virus replication in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478b7b3f7fa7ea5504f7b9f7e3270ea9
https://research.monash.edu/en/publications/da9c643d-7a59-4210-b481-826eef5de1b8
https://research.monash.edu/en/publications/da9c643d-7a59-4210-b481-826eef5de1b8