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pro vyhledávání: '"Darryl M. Wilson"'
Autor:
Darryl M. Wilson, Daniel J. Driedger, Dennis Y. Liu, Sandra Keerthisinghe, Adrian Hermann, Christoph Bieniossek, Roger G. Linington, Robert A. Britton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Polyketide or polyketide-like macrolides (pMLs) continue to serve as a source of inspiration for drug discovery. However, their inherent structural and stereochemical complexity challenges efforts to explore related regions of chemical space
Externí odkaz:
https://doaj.org/article/ade8a36322684d49b417cc35ec35dfe3
Autor:
Dennis Y. Liu, Laura Phillips, Darryl M. Wilson, Kelly M. Fulton, Susan M. Twine, Alex Wong, Roger G. Linington
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Collateral sensitivity (CS), whereby resistance to one drug is accompanied by increased sensitivity to another, provides new opportunities for antimicrobial drug discovery. Here, Liu et al. screen large chemical libraries across 29 drug-resistant E.
Externí odkaz:
https://doaj.org/article/9fab3deea0464cd0a3a2a46120dc904a