Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Darryl L. McDougald"'
Autor:
Elizabeth J. Beaudet, Ron Laethem, Steven J. Novick, Zhiyang Zhao, Thomas A. Brodie, Debie J. Hoivik, Andrews Robert Carl, Timothy K. Tippin, Edward L. LeCluyse, J. David Becherer, Jürgen M. Lehmann, Linda B. Moore, Darryl L. McDougald, Summer Jolley, Steven A. Kliewer, Michael D. Gaul, G. Hamilton, Kathy Mellon-Kusibab
Publikováno v:
Drug Metabolism and Disposition. 31:870-877
A series of N-hydroxyformamide tumor necrosis factor-alpha converting enzyme (TACE)/matrix metalloprotease (MMP) inhibitors were evaluated for their potential to induce human cytochrome P450 3A (CYP3A). Two in vitro assays were used: 1) a cell-based
Autor:
Millard H, Lambert, R Kevin, Blackburn, Theresa D, Seaton, Daniel B, Kassel, Daniel S, Kinder, M Anthony, Leesnitzer, D Mark, Bickett, Janet R, Warner, Marc W, Andersen, Jennifer G, Badiang, David J, Cowan, Michael D, Gaul, Kimberly G, Petrov, Michael H, Rabinowitz, Robert W, Wiethe, J David, Becherer, Darryl L, McDougald, David L, Musso, Robert C, Andrews, Marcia L, Moss
Publikováno v:
Combinatorial chemistryhigh throughput screening. 8(4)
We report a systematic analysis of the P1' and P2' substrate specificity of TNF-alpha converting enzyme (TACE) using a peptide library and a novel analytical method, and we use the substrate specificity information to design novel reverse hydroxamate