Výsledky vyhledávání - "Darryl L. Kirkpatrick"

Bimodal cardiac dysfunction in an animal model of iron overload

Autor: Wei Qiang Dong, Brian D. Hoit, Matthew N. Levy, Darryl L. Kirkpatrick, Arthur M. Brown, Carlos A. Obejero-Paz, Yuri A. Kuryshev, Tianen Yang, Gary M. Brittenham, Songsak Kiatchoosakun

Publikováno v: Journal of Laboratory and Clinical Medicine. 140:263-271

Iron-overload cardiomyopathy is the most common cause of death in patients with thalassemia major, yet the associated changes in cardiac function have not been quantified. We studied the effects of iron overload on cardiac function in Mongolian gerbi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f026623dd9ebb813bf974bff2c99432
https://doi.org/10.1067/mlc.2002.127725

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Naturally Occurring Variation in Cardiovascular Traits among Inbred Mouse Strains

Autor: Haifeng Shao, Brian D. Hoit, Joseph Restivo, Keith Olszens, Yoh Han Pao, Songsak Kiatchoosakun, Joseph H. Nadeau, Darryl L. Kirkpatrick

Publikováno v: Genomics. 79:679-685

The objective of this study was to characterize genetic variation in complex cardiovascular traits in two commonly used inbred mouse strains. We performed echocardiography, graded treadmill exercise, tail cuff plethysmography, and telemetry (heart ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a724f19158b92a0f5d4ccadbe993aedd
https://doi.org/10.1006/geno.2002.6754

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Disruption of a Single Copy of the SERCA2 Gene Results in Altered Ca2+ Homeostasis and Cardiomyocyte Function

Autor: Gary E. Shull, Darryl L. Kirkpatrick, Yanfang Xu, Muthu Periasamy, Nipavan Chiamvimonvat, Gopal J. Babu, M. Jane Lalli, Yong Ji, Richard A. Walsh, Lynne H. Liu

Publikováno v: Journal of Biological Chemistry. 275:38073-38080

A mouse model carrying a null mutation in one copy of the sarcoplasmic reticulum (SR) Ca(2+)-ATPase isoform 2 (SERCA2) gene, in which SERCA2 protein levels are reduced by approximately 35%, was used to investigate the effects of decreased SERCA2 leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e27bc541afe796506dff5b1de7045f
https://doi.org/10.1074/jbc.m004804200

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Enhanced Myocardial Contractility and Increased Ca 2+ Transport Function in Transgenic Hearts Expressing the Fast-Twitch Skeletal Muscle Sarcoplasmic Reticulum Ca 2+ -ATPase

Autor: Muthu Periasamy, Ingrid L. Grupp, Evgeny Loukianov, Richard A. Walsh, Gunter Grupp, Jonathan Lytton, Tanya Loukianova, Darryl L. Kirkpatrick, Yong Ji, Debra L. Baker

Publikováno v: Circulation Research. 83:889-897

Abstract —In this study, we investigated whether the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca 2+ transport pump (SERCA1a) can functionally substitute the cardiac SERCA2a isoform and how its overexpression affects cardiac contract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9098c83a1cc5d0a6320a449c234e0a34
https://doi.org/10.1161/01.res.83.9.889

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Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy

Autor: Roberto Bolli, Yasuchika Takeishi, Peipei Ping, Brian D. Hoit, Richard A. Walsh, Darryl L. Kirkpatrick

Publikováno v: Circulation research. 86(12)

Abstract —To test the hypothesis that activation of the protein kinase C (PKC) ε isoform leads to cardiac hypertrophy without failure, we studied transgenic mice with cardiac-specific overexpression of a constitutively active mutant of the PKCε i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb3a933cc3fa02632c36b21fe445591
https://pubmed.ncbi.nlm.nih.gov/10864911

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Alterations in Ca2+ cycling proteins and G alpha q signaling after left ventricular assist device support in failing human hearts

Autor: Darryl L. Kirkpatrick, William T. Abraham, Richard A. Walsh, Thunder Jalili, Brian D. Hoit, Yasuchika Takeishi, Lynne E. Wagoner

Publikováno v: Cardiovascular research. 45(4)

Objective: Left ventricular assist device support mechanically unloads the failing ventricle with resultant improvement in cardiac geometry and function in patients with end-stage heart failure. Activation of the Gαq signaling pathway, including pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5085d4d19c791ff645344ca124fa03f
https://pubmed.ncbi.nlm.nih.gov/10728414

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Effects of total replacement of atrial myosin light chain-2 with the ventricular isoform in atrial myocytes of transgenic mice

Autor: Corinn M. Pawloski-Dahm, Guojie Song, Darryl L. Kirkpatrick, Jeffrey Robbins, Richard A. Walsh, James Gulick, Joe Palermo, Gerald W. Dorn

Publikováno v: Circulation. 97(15)

Background —In contrast to their well-known and critical role in excitation-contraction coupling of vascular smooth muscle, the effects of the myosin light chains on cardiomyocyte mechanics are poorly understood. Accordingly, we designed the presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a72d89c9c73d66e657d3e10cdfdd24
https://pubmed.ncbi.nlm.nih.gov/9576432

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