Výsledky vyhledávání - "Darryl Irwin"

Akademický článek

Mutation analysis in individual circulating tumor cells depicts intratumor heterogeneity in melanoma

Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1560-1578 (2024)

Abstract Circulating tumor DNA (ctDNA) is the cornerstone of liquid biopsy diagnostics, revealing clinically relevant genomic aberrations from blood of cancer patients. Genomic analysis of single circulating tumor cells (CTCs) could provide additiona

Externí odkaz: https://doaj.org/article/4b6305c88a944631907935568207306e

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Akademický článek

Prognostic value of integrating circulating tumour cells and cell-free DNA in non-small cell lung cancer

Autor: Joanna Kapeleris, Juliana Müller Bark, Shanon Ranjit, Darryl Irwin, Gunter Hartel, Majid Ebrahimi Warkiani, Paul Leo, Connor O'Leary, Rahul Ladwa, Kenneth O'Byrne, Brett G.M. Hughes, Chamindie Punyadeera

Publikováno v: Heliyon, Vol 8, Iss 7, Pp e09971- (2022)

Background: Non-small cell lung cancer (NSCLC) often presents at an incurable stage, and majority of patients will be considered for palliative treatment at some point in their disease. Despite recent advances, the prognosis remains poor, with a medi

Externí odkaz: https://doaj.org/article/11794cb68225483fa0ba364384b113a6

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Akademický článek

Pre‐analytical factors affecting the establishment of a single tube assay for multiparameter liquid biopsy detection in melanoma patients

Publikováno v: Molecular Oncology, Vol 14, Iss 5, Pp 1001-1015 (2020)

The combination of liquid biomarkers from a single blood tube can provide more comprehensive information on tumor development and progression in cancer patients compared to single analysis. Here, we evaluated whether a combined analysis of circulatin

Externí odkaz: https://doaj.org/article/9e3df0b98bd64b93a6f200e8ad0438b0

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Akademický článek

Discovery of Targetable Genetic Alterations in NSCLC Patients with Different Metastatic Patterns Using a MassARRAY-Based Circulating Tumor DNA Assay

Autor: Yassine Belloum, Melanie Janning, Malte Mohme, Ronald Simon, Jolanthe Kropidlowski, Alexander Sartori, Darryl Irwin, Manfred Westphal, Katrin Lamszus, Sonja Loges, Sabine Riethdorf, Klaus Pantel, Harriet Wikman

Publikováno v: Cells, Vol 9, Iss 11, p 2337 (2020)

Circulating tumor DNA (ctDNA) has shown great promise as a minimally invasive liquid biopsy for personalized cancer diagnostics especially among metastatic patients. Here, we used a novel sensitive assay to detect clinically relevant mutations in ctD

Externí odkaz: https://doaj.org/article/5e71ad33583a4db885e88ab03c845aa4

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Akademický článek

Assessment of common somatic mutations of EGFR, KRAS, BRAF, NRAS in pulmonary non-small cell carcinoma using iPLEX® HS, a new highly sensitive assay for the MassARRAY® System.

Autor: Bobbie C Sutton, Ryan T Birse, Kevin Maggert, Tammy Ray, Jessica Hobbs, Amobi Ezenekwe, Jason Kazmierczak, Michael Mosko, Joan Kish, Andrew Bullock, Zonggao Shi, M Sharon Stack, Darryl Irwin

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0183715 (2017)

Increased early detection and personalized therapy for lung cancer have coincided with greater use of minimally invasive sampling techniques such as endobronchial ultrasound-guided biopsy (EBUS), endoscopic ultrasound-guided biopsy (EUS), and navigat

Externí odkaz: https://doaj.org/article/45c9b703ba884216b6928fdf615a89a8

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Akademický článek

Clinical validation of an ultra high-throughput spiral microfluidics for the detection and enrichment of viable circulating tumor cells.

Autor: Bee Luan Khoo, Majid Ebrahimi Warkiani, Daniel Shao-Weng Tan, Ali Asgar S Bhagat, Darryl Irwin, Dawn Pingxi Lau, Alvin S T Lim, Kiat Hon Lim, Sai Sakktee Krisna, Wan-Teck Lim, Yoon Sim Yap, Soo Chin Lee, Ross A Soo, Jongyoon Han, Chwee Teck Lim

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e99409 (2014)

BackgroundCirculating tumor cells (CTCs) are cancer cells that can be isolated via liquid biopsy from blood and can be phenotypically and genetically characterized to provide critical information for guiding cancer treatment. Current analysis of CTCs

Externí odkaz: https://doaj.org/article/03951ce56787415fbd46f96bac1202e5

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The identification of circulating tumour DNA using MassARRAY technology in non-small-cell lung cancer (NSCLC)

Autor: Connor O’Leary, Derek J. Richard, Vandhana Bharti, Darryl Irwin, Rahul Ladwa, Kenneth J. O'Byrne, Brett G.M. Hughes, Arutha Kulasinghe, James Monkman, Sanjay Dutta

Publikováno v: Lung Cancer. 160:73-77

Objectives: Attaining tumour material from lung cancer patients can be challenging with limited sample availability. Therefore, non-invasive means of assessing tumour material is becoming increasingly more important. Circulating tumour DNA (ctDNA), e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e92f54bd3b968ce6d5d8e0404b18f4b
https://doi.org/10.1016/j.lungcan.2021.08.005

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