Výsledky vyhledávání - "Darryl G. Turner"

Towards a unified analysis of Katcha nominal modifiers

Autor: Darryl G. Turner

Publikováno v: Faits de Langues. 51:141-160

This paper presents a description and analysis of the syntax of nominal modifiers in Katcha. The three main types of nominal modifiers in Katcha, demonstratives, possessive noun phrases and relative clauses, all agree with their head noun in gender,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9115877f75793a0ecd3db9a9c3acf004
https://doi.org/10.1163/19589514-05101009

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Akademický článek

T-bet expression by Foxp3+ T regulatory cells is not essential for their suppressive function in CNS autoimmune disease or colitis

Autor: Rhoanne C McPherson, Darryl G Turner, Iris eMair, Richard A O'Connor, Stephen M Anderton

Publikováno v: Frontiers in Immunology, Vol 6 (2015)

Accumulation of T regulatory (Treg) cells within the central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE) is essential for the resolution of disease. CNS Treg cells have been shown to uniformly express the Th1-associate

Externí odkaz: https://doaj.org/article/22861bbd869b48bc8a9a417e0778a776

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The interaction of number and gender in Katcha

Autor: Darryl G. Turner

Publikováno v: Studies in African Linguistics, Vol 47, Iss 1 (2018)

The Kadu languages of Sudan’s Nuba Mountains have been the subject of an ongoing controversy regarding whether they should be classified as Niger-Congo, Nilo-Saharan, or as an independent family. Against this background, I present novel data from n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d242818140b791a0327b43660573f46f
https://doi.org/10.32473/sal.v47i1.107656

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251 The use of small molecule inhibitors to target novel pathways in exhausted T cells for immuno-oncology therapeutic intervention

Autor: Hayley Gooding, Courtney Grant, Justyna Rzepecka, Mark Barbour, Darryl G. Turner, Joanne Hay, Rhoanne C. McPherson, Preeti Singh, Francis Acklam

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundThe ability to reverse exhaustion in CD8+ T cells holds great promise for therapeutic intervention in oncology. Indeed, treatment with therapeutics targeted at checkpoint inhibitors, such as Nivolumab (anti-PD-1), have shown great promise i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a69b52d774faff4f95795941eb5add
https://doi.org/10.1136/jitc-2021-sitc2021.251

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Abstract 3877: MPL-5821, a macrophage targeted ESMTM p38 MAPK inhibitor, inhibits the production of TLR agonist induced IL-10 whilst sparing T-cell functionality

Autor: Doris Clare Louise, Stephen M. Anderton, Tanja D. de Gruijl, Justyna Rzepecka, A. Marijne Heeren, Darryl G. Turner, Gary Newton, Lucia Janicova, Kathryn Chapman, David Festus Charles Moffat, Anastasia Nika, Claire Tebbutt, Martin J. Perry

Publikováno v: Cancer Research. 78:3877-3877

Compensatory release of immunosuppressive cytokines, such as IL-10, by macrophages present in the tumor microenvironment has been implicated as a mechanism for adaptive resistance to a number of immunotherapies. Our drug discovery effort utilises Est

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8be6d99158a8a71fa63eaef4e856ae46
https://doi.org/10.1158/1538-7445.am2018-3877

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Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors

Autor: Emily J, Colbeck, James P, Hindley, Kathryn, Smart, Emma, Jones, Anja, Bloom, Hayley, Bridgeman, Rhoanne C, McPherson, Darryl G, Turner, Kristin, Ladell, David A, Price, Richard A, O'Connor, Stephen M, Anderton, Andrew J, Godkin, Awen M, Gallimore

Publikováno v: Oncotarget

Foxp3(+) regulatory T cells (Tregs) are often highly enriched within the tumor-infiltrating T cell pool. Using a well-characterised model of carcinogen-induced fibrosarcomas we show that the enriched tumor-infiltrating Treg population comprises large

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ea72491059ba2df9a95238f2222bba6
https://pubmed.ncbi.nlm.nih.gov/26433463

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Methods for Ex Vivo Analysis of Immune Cell Function from the Central Nervous System

Autor: Darryl G, Turner, Melanie D, Leech, Richard A, O'Connor, Stephen M, Anderton

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1304

Experimental autoimmune encephalomyelitis (EAE) is an animal model commonly used to investigate the inflammatory response in organ-specific autoimmunity and a model of the early immune responses of multiple sclerosis.This protocol outlines the method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b32a211e6e77b23ec1e7278e730a4788
https://pubmed.ncbi.nlm.nih.gov/25863784

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T-bet Expression by Foxp3+ T Regulatory Cells is Not Essential for Their Suppressive Function in CNS Autoimmune Disease or Colitis

Autor: Stephen M. Anderton, Darryl G. Turner, Iris Mair, Richard A. O’Connor, Rhoanne C. McPherson

Publikováno v: Frontiers in Immunology
McPherson, R C, Turner, D G, Mair, I, O'Connor, R A & Anderton, S M 2015, ' T-bet Expression by Foxp3(+) T Regulatory Cells is Not Essential for Their Suppressive Function in CNS Autoimmune Disease or Colitis ', Frontiers in Immunology, vol. 6, pp. 69 . https://doi.org/10.3389/fimmu.2015.00069
Frontiers in Immunology, Vol 6 (2015)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f8511b14990eea38818ff04c0c52c1
https://doi.org/10.3389/fimmu.2015.00069

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Exposure to inflammatory cytokines selectively limits GM-CSF production by induced T regulatory cells

Autor: Ben C, Reynolds, Darryl G, Turner, Rhoanne C, McPherson, Catriona T, Prendergast, Richard G, Phelps, Neil A, Turner, Richard A, O'Connor, Stephen M, Anderton

Publikováno v: European Journal of Immunology

Interest in manipulating the immunosuppressive powers of Foxp3-expressing T regulatory cells as an immunotherapy has been tempered by their reported ability to produce proinflammatory cytokines when manipulated in vitro, or in vivo. Understanding pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::91dda3156afbe17061f52e046afa6718
https://pubmed.ncbi.nlm.nih.gov/25168419

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Cutting edge: IL-6-dependent autoimmune disease: dendritic cells as a sufficient, but transient, source

Autor: Tom A. Barr, Darryl G. Turner, Stephen M. Anderton, David Gray, Sheila Brown, Richard A. O’Connor, Richard J. Mellanby, Melanie D. Leech

Publikováno v: Leech, M D, Barr, T A, Turner, D G, Brown, S, O'Connor, R A, Gray, D, Mellanby, R J & Anderton, S M 2013, ' Cutting Edge : IL-6-Dependent Autoimmune Disease: Dendritic Cells as a Sufficient, but Transient, Source ', Journal of Immunology, vol. 190, no. 3, pp. 881-885 . https://doi.org/10.4049/jimmunol.1202925

Mice lacking IL-6 are resistant to autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE), which is driven by CNS-reactive CD4+ T cells. There are multiple cellular sources of IL-6, but the critical source in EAE has been uncert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e5d5bb0182e50bc46d77234e0a7f88
https://pubmed.ncbi.nlm.nih.gov/23267024

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