Zobrazeno 1 - 10
of 2 006
pro vyhledávání: '"Darryl C, Zeldin"'
Autor:
Charlotte Hateley, Antoni Olona, Laura Halliday, Matthew L. Edin, Jeong-Hun Ko, Roberta Forlano, Ximena Terra, Fred B. Lih, Raúl Beltrán-Debón, Penelopi Manousou, Sanjay Purkayastha, Krishna Moorthy, Mark R. Thursz, Guodong Zhang, Robert D. Goldin, Darryl C. Zeldin, Enrico Petretto, Jacques Behmoaras
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105127- (2024)
Summary: Background: Obesity drives maladaptive changes in the white adipose tissue (WAT) which can progressively cause insulin resistance, type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated liver disease (MASLD). Obesity-mediated l
Externí odkaz:
https://doaj.org/article/f522db65b00f4ac6b5690aad31edc432
Autor:
Paivi M. Salo, PhD, Lara J. Akinbami, MD, Michelle M. Cloutier, MD, Jesse C. Wilkerson, BS, Kurtis S. Elward, MD, Jacek M. Mazurek, MD, PhD, Gregory B. Diette, MD, Tracey A. Mitchell, RRT, AE-C, Sonja Williams, BS, MPH, Darryl C. Zeldin, MD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 1, Pp 100192- (2024)
Background: The National Asthma Education and Prevention Program guidelines emphasize environmental control as an integral part of asthma management; however, limited national-level data exist on how clinicians implement environmental control recomme
Externí odkaz:
https://doaj.org/article/4b35efd226e344a38773ec95087774f1
Autor:
Paivi M. Salo, Angelico Mendy, Jesse Wilkerson, Samantha A. Molsberry, Lydia Feinstein, Stephanie J. London, Michael B. Fessler, Peter S. Thorne, Darryl C. Zeldin
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background Oxidative stress plays a key role in the pathogenesis of respiratory diseases; however, studies on antioxidant vitamins and respiratory outcomes have been conflicting. We evaluated whether lower serum levels of vitamins A, C, D, a
Externí odkaz:
https://doaj.org/article/20f63ceab6f74a26a38ab14e87f2f4f7
Autor:
Nathaniel MacNell, Lydia Feinstein, Jesse Wilkerson, Pӓivi M Salo, Samantha A Molsberry, Michael B Fessler, Peter S Thorne, Alison A Motsinger-Reif, Darryl C Zeldin
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280387 (2023)
Despite the prominent use of complex survey data and the growing popularity of machine learning methods in epidemiologic research, few machine learning software implementations offer options for handling complex samples. A major challenge impeding th
Externí odkaz:
https://doaj.org/article/b33f611be50144cfb463297b797ed985
Autor:
Deanna K. Sosnowski, K. Lockhart Jamieson, Ahmed M. Darwesh, Hao Zhang, Hedieh Keshavarz-Bahaghighat, Robert Valencia, Anissa Viveiros, Matthew L. Edin, Darryl C. Zeldin, Gavin Y. Oudit, John M. Seubert
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
ObjectiveMetabolites derived from N−3 and N−6 polyunsaturated fatty acids (PUFAs) have both beneficial and detrimental effects on the heart. However, contribution of these lipid mediators to dilated cardiomyopathy (DCM)-associated mitochondrial d
Externí odkaz:
https://doaj.org/article/61ddb9d2de3445089431a52f40b77b22
Publikováno v:
Environmental Health, Vol 19, Iss 1, Pp 1-10 (2020)
Abstract Background Endotoxin is ubiquitous in the environment, but its clustering with indoor allergens is not well characterized. This study examined the clustering patterns of endotoxin with allergens in house dust and their association with asthm
Externí odkaz:
https://doaj.org/article/408e267e646e499ba9ee3fffda4e7a78
Autor:
Melissa V. Chan, Melissa A. Hayman, Suthesh Sivapalaratnam, Marilena Crescente, Harriet E. Allan, Matthew L. Edin, Darryl C. Zeldin, Ginger L. Milne, Jonathan Stephens, Daniel Greene, Moghees Hanif, Valerie B. O'Donnell, Liang Dong, Michael G. Malkowski, Claire Lentaigne, Katherine Wedderburn, Matthew Stubbs, Kate Downes, Willem H. Ouwehand, Ernest Turro, NIHR BioResource, Daniel P. Hart, Kathleen Freson, Michael A. Laffan, Timothy D. Warner
Publikováno v:
Haematologica, Vol 106, Iss 5 (2020)
We have identified a rare missense variant on chromosome 9, position 125145990 (GRCh37), in exon 8 in PTGS1 (the gene encoding cyclo-oxygenase 1, COX-1, the target of anti-thrombotic aspirin therapy). We report that in the homozygous state within a l
Externí odkaz:
https://doaj.org/article/67d8336da71a4f9fa0252ac3ddc88ca1
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Previously, we showed vascular endothelial overexpression of human-CYP2J2 enhances coronary reactive hyperemia in Tie2-CYP2J2 Tr mice, and eNOS−/− mice had overexpression of CYP2J-epoxygenase with adenosine A2A receptor-induced enhance relaxation
Externí odkaz:
https://doaj.org/article/639a48947b044217a1b548b4afd9c422
Autor:
Antoni Olona, Ximena Terra, Jeong-Hun Ko, Carme Grau-Bové, Montserrat Pinent, Anna Ardevol, Ana Garcia Diaz, Aida Moreno-Moral, Matthew Edin, David Bishop-Bailey, Darryl C. Zeldin, Timothy J. Aitman, Enrico Petretto, Mayte Blay, Jacques Behmoaras
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 18-32 (2018)
Objective: When molecular drivers of healthy adipogenesis are perturbed, this can cause hepatic steatosis. The role of arachidonic acid (AA) and its downstream enzymatic cascades, such as cyclooxygenase, in adipogenesis is well established. The exact
Externí odkaz:
https://doaj.org/article/d7285575e91349bf8008e12a518b25d1
Autor:
Deanna K. Sosnowski, K. Lockhart Jamieson, Artiom Gruzdev, Yingxi Li, Robert Valencia, Ala Yousef, Zamaneh Kassiri, Darryl C. Zeldin, John M. Seubert
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H670-H687
Endotoxemia elicits a multiorgan inflammatory response that results in cardiac dysfunction and often leads to death. Inflammation-induced metabolism of endogenous N-3 and N-6 polyunsaturated fatty acids generates numerous lipid mediators, such as epo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da665ab88e4b36717deafd25add253c
https://doi.org/10.1152/ajpheart.00217.2022
https://doi.org/10.1152/ajpheart.00217.2022