Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Darryl A Knight"'
Autor:
Tylah Miles, Gerard F Hoyne, Darryl A Knight, Mark W Fear, Steven E Mutsaers, Cecilia M Prêle
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 7, Pp n/a-n/a (2020)
Abstract Pulmonary fibrosis occurs in a heterogeneous group of lung disorders and is characterised by an excessive deposition of extracellular matrix proteins within the pulmonary interstitium, leading to impaired gas transfer and a loss of lung func
Externí odkaz:
https://doaj.org/article/c4411332b0ed47deac6487b7ba36ef37
Autor:
Ryan D Huff, Alan C-Y Hsu, Kristy S Nichol, Bernadette Jones, Darryl A Knight, Peter A B Wark, Philip M Hansbro, Jeremy A Hirota
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184260 (2017)
The airway epithelium is a physical and immunological barrier that protects the pulmonary system from inhaled environmental insults. Uric acid has been detected in the respiratory tract and can function as an antioxidant or damage associated molecula
Externí odkaz:
https://doaj.org/article/90365bbb82034734925b72509ab31da5
Publikováno v:
International Journal of COPD, Vol 2010, Iss default, Pp 81-88 (2010)
Tillie L Hackett1,2, Darryl A Knight1,2, Don D Sin1,31UBC James Hogg Research Centre, Heart and Lung Institute, St Paul’s Hospital, Vancouver, BC, Canada, V6Z 1Y6; 2Department of Anesthesiology, Pharmacology and Therapeutics, 3Department of Medicin
Externí odkaz:
https://doaj.org/article/212420069df949f399b466079c86f3a3
Autor:
Balarka Banerjee, Michael Musk, Erika N Sutanto, Stephanie T Yerkovich, Peter Hopkins, Darryl A Knight, Suzanna Lindsey-Temple, Stephen M Stick, Anthony Kicic, Daniel C Chambers
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52309 (2012)
ObjectiveDysregulated repair following epithelial injury is a key forerunner of disease in many organs, and the acquisition of a mesenchymal phenotype by the injured epithelial cells (epithelial to mesenchymal transition, EMT) may serve as a source o
Externí odkaz:
https://doaj.org/article/6aeeacc9ffd64d5392193b4765bf2bf6
Autor:
Wendy A Boivin, Marlo Shackleford, Amanda Vanden Hoek, Hongyan Zhao, Tillie L Hackett, Darryl A Knight, David J Granville
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33163 (2012)
Granzyme B (GrB) is a pro-apoptotic serine protease that contributes to immune-mediated target cell apoptosis. However, during inflammation, GrB accumulates in the extracellular space, retains its activity, and is capable of cleaving extracellular ma
Externí odkaz:
https://doaj.org/article/ad5dc085bc9d481f91f4d6709fe523c0
Autor:
Dorota Stefanowicz, Tillie-Louise Hackett, Farshid S Garmaroudi, Oliver P Günther, Sarah Neumann, Erika N Sutanto, Kak-Ming Ling, Michael S Kobor, Anthony Kicic, Stephen M Stick, Peter D Paré, Darryl A Knight
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44213 (2012)
Allergic inflammation is commonly observed in a number of conditions that are associated with atopy including asthma, eczema and rhinitis. However, the genetic, environmental or epigenetic factors involved in these conditions are likely to be differe
Externí odkaz:
https://doaj.org/article/f362098c258c4c54be8e48fb965bc047
Autor:
Jean L Oosthuizen, Pol Gomez, Jian Ruan, Tillie L Hackett, Margo M Moore, Darryl A Knight, Scott J Tebbutt
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20527 (2011)
Given the complex nature of the responses that can occur in host-pathogen interactions, dual transcriptomics offers a powerful method of elucidating these interactions during infection. The gene expression patterns of Aspergillus fumigatus conidia or
Externí odkaz:
https://doaj.org/article/47fa0891741247b68b25e2f0251503e8
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21484 (2011)
Granzyme K (GrK) is a trypsin-like serine protease that is elevated in patients with sepsis and acute lung inflammation. While GrK was originally believed to function exclusively as a pro-apoptotic protease, recent studies now suggest that GrK may po
Externí odkaz:
https://doaj.org/article/72a544f4ab3d4a539ffcd0acaf0d39c4
Autor:
Lynne A Murray, Tillie L Hackett, Stephanie M Warner, Furquan Shaheen, Rochelle L Argentieri, Paul Dudas, Francis X Farrell, Darryl A Knight
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e4039 (2008)
Bone morphogenic protein (BMP)-7 is a member of the BMP family which are structurally and functionally related, and part of the TGFbeta super family of growth factors. BMP-7 has been reported to inhibit renal fibrosis and TGFbeta1-induced epithelial-
Externí odkaz:
https://doaj.org/article/aaff4464c87b4da18f8a904246b05236
Autor:
Punnam Chander Veerati, Kristy S. Nichol, Jane M. Read, Nathan W. Bartlett, Peter A. B. Wark, Darryl A. Knight, Christopher L. Grainge, Andrew T. Reid
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 323:L495-L502
Primary bronchial epithelial cells (pBECs) obtained from donors have limited proliferation capacity. Recently, conditional reprogramming (CR) technique has overcome this and has provided the potential for extended passaging and subsequent differentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2efd4b170ba02b8b9071701544e1e887
https://doi.org/10.1152/ajplung.00230.2022
https://doi.org/10.1152/ajplung.00230.2022