Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Darrin Dutcher"'
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
Supplementary Material and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820b42e67f47200c9c178cedb99c7c5a
https://doi.org/10.1158/1535-7163.22520580.v1
https://doi.org/10.1158/1535-7163.22520580.v1
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
IHC for cleaved caspase-8 and cleaved caspase-3 24h after the second administration of BI 905711 in GP2d xenograft tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334db19e87c0561dd5ecdc1dc054e314
https://doi.org/10.1158/1535-7163.22520589
https://doi.org/10.1158/1535-7163.22520589
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
TRAILR2 and CDH17 RNA expression in related normal tissues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9560d6e2b4b46726815d4bccfef4cc
https://doi.org/10.1158/1535-7163.22520598
https://doi.org/10.1158/1535-7163.22520598
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
S1: Evaluation of CDH17 and TRAILR2 IHC staining in hepatic metastases of colorectal cancer -S2:BI 905711 kinetic and steady-state measurements -S3: CDH17 and TRAILR2 mean fluorescence intensity, antibody binding capacity and BI 905711 / TAS266' minP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b6cd5ccfd8bf8bdf5d258d7c9e5b48
https://doi.org/10.1158/1535-7163.22520577.v1
https://doi.org/10.1158/1535-7163.22520577.v1
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
Activation of TRAILR2 has emerged as an important therapeutic concept in cancer treatment. TRAILR2 agonistic molecules have only had limited clinical success, to date, due either to lack of efficacy or hepatotoxicity. BI 905711 is a novel tetravalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643c72c3613f080a868d2bc5298534ff
https://doi.org/10.1158/1535-7163.c.6542688.v1
https://doi.org/10.1158/1535-7163.c.6542688.v1
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
Impact of CDH17 targeting on bi-specific molecules in vivo efficacy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e0d16e39e2e6b3686d8b7631b3361a
https://doi.org/10.1158/1535-7163.22520586.v1
https://doi.org/10.1158/1535-7163.22520586.v1
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
CDH17 and TRAILR2 protein expression and their correlation with BI 905711 minPOC in CRC cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38aa14b46284ea44df094012bd436cc9
https://doi.org/10.1158/1535-7163.22520592
https://doi.org/10.1158/1535-7163.22520592
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
Effect of BI 905711-mediated tumor cell death on dendritic cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6bbbe7622d261ff5f02394dd4c4de1
https://doi.org/10.1158/1535-7163.22520595
https://doi.org/10.1158/1535-7163.22520595
Autor:
Bernd Weigle, Monica Menzenski, Pankaj Gupta, Sarah Low, Rachel Kroe-Barrett, Kavita Jerath, Sathyadevi Venkataramani, Klaus J. Erb, Rajkumar Ganesan, Darrin Dutcher, Sanjaya Singh, Kristopher Truncali, Lee Frego
Publikováno v:
Biochemical and Biophysical Research Communications. 504:19-24
Patients with severe Th2 type asthma often have a steroid resistant phenotype and are prone to acute exacerbations. Current novel therapies have only marginal therapeutic effects. One of the hypotheses for lack of major efficacy in most patients is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac9118b8fce286b145bbeac305fceb8
https://doi.org/10.1016/j.bbrc.2018.08.064
https://doi.org/10.1016/j.bbrc.2018.08.064
Autor:
Darin Smith, Guy Vigers, Sumeet Rana, Michael Burkard, April Cox, Robert D. Groneberg, Ryan J. Watts, Robert Kirk Delisle, Tony Pisal Tang, Andrew T. Metcalf, Kelly Regal, Susan P. Rhodes, Mary K. Geck Do, Karin D. Brown, Joseph P. Lyssikatos, Douglas Mccord Sammond, Matthew Volgraf, Albion D. Wright, Gunawardana Indrani W, Kimberly Scearce-Levie, Jennifer N. Otten, Allen A. Thomas, Michael Siu, Hans E. Purkey, Kevin W. Hunt, Xingrong Liu, Darrin Dutcher
Publikováno v:
Journal of Medicinal Chemistry. 57:878-902
In an attempt to increase selectivity vs Cathepsin D (CatD) in our BACE1 program, a series of 1,3,4,4a,10,10a-hexahydropyrano[4,3-b]chromene analogues was developed. Three different Asp-binding moieties were examined: spirocyclic acyl guanidines, ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936cb574f0793c10f3925c44b16b4302
https://doi.org/10.1021/jm401635n
https://doi.org/10.1021/jm401635n