Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Darrian Bugg"'
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106502- (2023)
Summary: RNA-binding protein muscleblind-like1 (MBNL1) was recently identified as a central regulator of cardiac wound healing and myofibroblast activation. To identify putative MBNL1 targets, we integrated multiple genome-wide screens with a fibrobl
Externí odkaz:
https://doaj.org/article/f24a75589db24851a18f5f33a11002cd
Autor:
Shanshan Cai, Mingyue Zhao, Bo Zhou, Akira Yoshii, Darrian Bugg, Outi Villet, Anita Sahu, Gregory S. Olson, Jennifer Davis, Rong Tian
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Innate immune cells play important roles in tissue injury and repair following acute myocardial infarction (MI). Although reprogramming of macrophage metabolism has been observed during inflammation and resolution phases, the mechanistic link to macr
Externí odkaz:
https://doaj.org/article/e3581f7d6a324f0087a40889fbd6dc76
Autor:
Ross C. Bretherton, Amanda J. Haack, Irina Kopyeva, Fariha Rahman, Jonah D. Kern, Darrian Bugg, Ashleigh B. Theberge, Jennifer Davis, Cole A. DeForest
Publikováno v:
Advanced Materials. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1c799548c0590244674e0b6716a4d51
https://doi.org/10.1002/adma.202209904
https://doi.org/10.1002/adma.202209904
Autor:
Logan R.J. Bailey, Darrian Bugg, Isabella M. Reichardt, C. Dessirée Ortaç, Jagadambika Gunaje, Richard Johnson, Michael J. MacCoss, Tomoya Sakamoto, Daniel P. Kelly, Michael Regnier, Jennifer M. Davis
Publikováno v:
bioRxiv
Discovering determinants of cardiomyocyte maturity and the maintenance of differentiated states is critical to both understanding development and potentially reawakening endogenous regenerative programs in adult mammalian hearts as a therapeutic stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798661f981b32b0da1227afeda653544
https://europepmc.org/articles/PMC10055038/
https://europepmc.org/articles/PMC10055038/
Autor:
Ross C. Bretherton, Isabella M. Reichardt, Kristin A. Zabrecky, Alex J. Goldstein, Logan R.J. Bailey, Darrian Bugg, Timothy S. McMillen, Kristina B. Kooiker, Galina V. Flint, Amy Martinson, Jagdambika Gunaje, Franziska Koser, Elizabeth Plaster, Wolfgang A. Linke, Michael Regnier, Farid Moussavi-Harami, Nathan J. Sniadecki, Cole A. DeForest, Jennifer Davis
Publikováno v:
bioRxiv
Inherited mutations in contractile and structural genes, which decrease cardiomyocyte tension generation, are principal drivers of dilated cardiomyopathy (DCM)– the leading cause of heart failure1,2. Progress towards developing precision therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d6d727242a076bceeee75ea3108274
https://europepmc.org/articles/PMC9900749/
https://europepmc.org/articles/PMC9900749/
Autor:
Shanshan Cai, Mingyue Zhao, Bo Zhou, Akira Yoshii, Darrian Bugg, Outi Villet, Anita Sahu, Gregory S. Olson, Jennifer Davis, Rong Tian
Publikováno v:
The Journal of clinical investigation.
Innate immune cells play important roles in tissue injury and repair following acute myocardial infarction (MI). Although reprogramming of macrophage metabolism has been observed during inflammation and resolution phases, the mechanistic link to macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46c8ad2db9f69f90e868d2f1e29876c
https://pubmed.ncbi.nlm.nih.gov/36480284
https://pubmed.ncbi.nlm.nih.gov/36480284
Autor:
Sonette Steczina, Jennifer Davis, Charles E. Murry, Darrian Bugg, Amy M. Martinson, Kevin M. Beussman, Danny El-Nachef, Nathan J. Sniadecki
Publikováno v:
Circulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d80622d0cb7e05a6a9916214bc4435
https://doi.org/10.1161/circulationaha.119.044974
https://doi.org/10.1161/circulationaha.119.044974
Autor:
Abigail Nagle, Kelly R. Stevens, Deok Ho Kim, Peter Kim, Nickolas Chu, Cole A. DeForest, Darrian Bugg, Ross C. Bretherton, Jagadambika J. Gunaje, Jennifer Davis, Emily Olszewski, Austin E Schumacher
Publikováno v:
Circ Res
Rationale: Myocardial infarction causes spatial variation in collagen organization and phenotypic diversity in fibroblasts, which regulate the heart’s ECM (extracellular matrix). The relationship between collagen structure and fibroblast phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25210412b19270bc37b8186678080ccc
https://doi.org/10.1161/circresaha.119.316162
https://doi.org/10.1161/circresaha.119.316162
Autor:
Darrian Bugg, Logan R.J. Bailey, Ross C. Bretherton, Kylie E. Beach, Isabella M. Reichardt, Kalen Z. Robeson, Anna C. Reese, Jagadambika Gunaje, Galina Flint, Cole A. DeForest, April Stempien-Otero, Jennifer Davis
Publikováno v:
Cell Stem Cell
Dynamic fibroblast to myofibroblast state transitions underlie the heart's fibrotic response. Because transcriptome maturation by muscleblind-like 1 (MBNL1) promotes differentiated cell states, this study investigated whether tactical control of MBNL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c7d34019387b957fcbc8679f717919
https://europepmc.org/articles/PMC8929295/
https://europepmc.org/articles/PMC8929295/
Autor:
Njabulo Ngwenyama, Kuljeet Kaur, Darrian Bugg, Brandon Theall, Mark Aronovitz, Robert Berland, Smaro Panagiotidou, Caroline Genco, Mercio A. Perrin, Jennifer Davis, Pilar Alcaide
Publikováno v:
Nature Cardiovascular Research. 1:1230-1230
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::690945944168269f49c50ad556ce7779
https://doi.org/10.1038/s44161-022-00179-6
https://doi.org/10.1038/s44161-022-00179-6