Výsledky vyhledávání - "Darren Wolfe"

Abstract 3042: BXQ-350 may protect peripheral nerves from the direct cytotoxicity of chemotherapeutic agents leading to chemotherapy induced peripheral neuropathy

Autor: Nikhil Wilkins, Tim Stephens, Robin Furnish, Charlie Cruze, Darren Wolfe, Gilles H. Tapolsky, Ray Takigiku

Publikováno v: Cancer Research. 83:3042-3042

Background: Chemotherapy Induced Peripheral Neuropathy (CIPN) is a debilitating side effect associated with many antineoplastic chemotherapeutic agents including cytotoxic and targeted agents. It significantly impacts cancer patients’ quality of li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c74b76e09a2164140792ad82488c69b0
https://doi.org/10.1158/1538-7445.am2023-3042

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Targeting IL-13Rα2 for effective treatment of malignant peripheral nerve sheath tumors in mouse models

Autor: James R. Connor, A. B. Madhankumar, Alexandre J. Bourcier, Christine Mau, Darren Wolfe, Elias Rizk, Oliver D. Mrowczynski, Kimberly Harbaugh, Becky Slagle-Webb, Stephan B. Abramson, Russell Payne, Ganesh Shenoy

Publikováno v: Journal of Neurosurgery. 131:1369-1379

OBJECTIVEMalignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas that harbor a high potential for metastasis and have a devastating prognosis. Combination chemoradiation aids in tumor control and decreases tumor recurren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c66212fedd7188a4a1ad233b9c0e8f
https://doi.org/10.3171/2018.7.jns18284

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Bedside to benchtop translational development: Targeting the S1P/ceramide axis may alleviate symptoms of chemical induced peripheral neuropathy

Autor: Ray Takigiku, Robert Wesolowski, Olivier Rixe, John Charles Morris, Emrullah Yilmaz, John L. Villano, Carolyn Muller, Richard Charles Curry, Vinay K. Puduvalli, Trisha Michel Wise-Draper, Darren Wolfe, Gilles Tapolsky

Publikováno v: Journal of Clinical Oncology. 40:e15045-e15045

e15045 Background: Chemical Induced Peripheral Neuropathy (CIPN) is a debilitating and serious side-effect associated with many chemotherapeutic treatments. Often, CIPN is a dose-limiting toxicity, and its effects can be long-lasting in some patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78164a56b513a0cf7268aec4fbae82a6
https://doi.org/10.1200/jco.2022.40.16_suppl.e15045

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Effects of Herpes Simplex Virus Vector–Mediated Enkephalin Gene Therapy on Bladder Overactivity and Nociception

Autor: William F. Goins, James R. Goss, David Krisky, Naoki Yoshimura, Tomohiko Oguchi, Osamu Nishizawa, Hitoshi Yokoyama, Darren Wolfe, William C. de Groat, Joseph C. Glorioso

Publikováno v: Human Gene Therapy. 24:170-180

We previously reported the effects of herpes simplex virus (HSV) vector-mediated enkephalin on bladder overactivity and pain. In this study, we evaluated the effects of vHPPE (E1G6-ENK), a newly engineered replication-deficient HSV vector encoding hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::806486d9338a9687ea862e707cd328e5
https://doi.org/10.1089/hum.2011.180

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Comparative effectiveness of antinociceptive gene therapies in animal models of diabetic neuropathic pain

Autor: Phillip G. Popovich, David Krisky, James R. Goss, E A Chiocca, M O Nowicki, Xin Wang, J Wechuk, Soledad Fernandez, W D Arnold, Xiaokui Mo, Sean E. Lawler, Yan Wang, Darren Wolfe

Publikováno v: Gene Therapy. 20:742-750

Peripheral neuropathic pain is one of the most common and debilitating complications of diabetes. Several genes have been shown to be effective in reducing neuropathic pain in animal models of diabetes after transfer to the dorsal root ganglion using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77d1ddb4e105578c7aaa0f95671abec
https://doi.org/10.1038/gt.2012.90

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Translating Gene Therapy for Pain from Animal Studies to the Clinic

Autor: David Krisky, David J. Fink, Marina Mata, James B. Wechuck, Darren Wolfe, James R. Goss

Publikováno v: Translational Neuroscience ISBN: 9781489976529

The use of gene transfer techniques, designed to effect the continuous release of analgesic peptides, offers the possibility to treat what may otherwise be intractable pain. In this chapter, we review the biology underlying this approach, the results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2548feac33b4c5a3fde6f96d5b90a954
https://doi.org/10.1007/978-1-4899-7654-3_10

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Gene Therapy for Neurogenic Erectile Dysfunction

Autor: Joseph C. Glorioso, Naoki Yoshimura, Michael B. Chancellor, James B. Wechuck, Fernando De Miguel, Jang Hang Kim, William F. Goins, Joel B. Nelson, Christian H. Coyle, Nelson E. Bennett, Ryuichi Kato, Darren Wolfe, Shaohua Huang, Taiji Tsukamoto

Publikováno v: LUTS: Lower Urinary Tract Symptoms. 1:S44-S47

Neurogenic erectile dysfunction (ED) is one of major causes of ED and is often difficult to treat. In this review, we report significant improvements of ED caused by diabetes mellitus (DM) or cavernous nerve injury by using a gene therapy approach in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::638d0bf5fc3913aeedc7d4eb13557816
https://doi.org/10.1111/j.1757-5672.2009.00045.x

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Effects of transgene-mediated endomorphin-2 in inflammatory pain

Autor: Joseph C. Glorioso, Marina Mata, David Fink, Darren Wolfe, Shuanglin Hao

Publikováno v: European Journal of Pain. 13:380-386

We examined the analgesic properties of endomorphin-2 expressed in DRG neurons transduced with a non-replicating herpes simplex virus (HSV)-based vector containing a synthetic endomorphin-2 gene construct. HSV-mediated endomorphin-2 expression reduce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361f1772eea0e3da578726813ff7a51a
https://doi.org/10.1016/j.ejpain.2008.05.008

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A human trial of HSV-mediated gene transfer for the treatment of chronic pain

Autor: David J. Fink, Marina Mata, Darren Wolfe

Publikováno v: Gene Therapy. 16:455-460

Gene transfer to the dorsal root ganglion using replication defective herpes simplex virus (HSV)-based vectors reduces pain-related behaviors in rodent models having inflammatory pain, neuropathic pain and pain caused by cancer in bone. HSV vectors e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b66d008378d2286fd38b90416078b03
https://doi.org/10.1038/gt.2009.17

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Herpes Simplex Virus-Mediated Expression of Pax3 and MyoD in Embryoid Bodies Results in Lineage-Related Alterations in Gene Expression Profiles

Autor: Ying Jiang, Darren Wolfe, David Krisky, April M. Craft, James B. Wechuck, Edward K. Lobenhofer, Joseph C. Glorioso

Publikováno v: Stem Cells. 26:3119-3129

The ability of embryonic stem cells to develop into multiple cell lineages provides a powerful resource for tissue repair and regeneration. Gene transfer offers a means to dissect the complex events in lineage determination but is limited by current

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c105820502e1e99952cc74df060419
https://doi.org/10.1634/stemcells.2008-0417

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