Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Darren T, Hwee"'
Autor:
Victor N. Rivas, Amanda E. Crofton, Carina E. Jauregui, Jalena R. Wouters, Betty S. Yang, Luke A. Wittenburg, Joanna L. Kaplan, Darren T. Hwee, Anne N. Murphy, Bradley P. Morgan, Fady I. Malik, Samantha P. Harris, Joshua A. Stern
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Hypertrophic cardiomyopathy (HCM) remains the most common cardiomyopathy in humans and cats with few preclinical pharmacologic interventional studies. Small-molecule sarcomere inhibitors are promising novel therapeutics for the management of
Externí odkaz:
https://doaj.org/article/1940ab1525324fb69489f617ae0a6c84
Autor:
Ashley N. Sharpe, Maureen S. Oldach, Victor N. Rivas, Joanna L. Kaplan, Ashley L. Walker, Samantha L. Kovacs, Darren T. Hwee, Peadar Cremin, Bradley P. Morgan, Fady I. Malik, Samantha P. Harris, Joshua A. Stern
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiac disease in humans and cats and lacks efficacious pharmacologic interventions in the preclinical phase of disease. LV outflow tract obstruction (LVOTO) is commonly obse
Externí odkaz:
https://doaj.org/article/3ef6018c3c88481d88035def01a77db8
Autor:
Aaron C. Hinken, Morgan Bradley P, Bing Yao, Jeffrey Warrington, Antonio A. Romero, Kevin Lu, David J. Morgans, Jeffrey Gardina, James J. Hartman, Chihyuan Chuang, Anna Marquez, Gustave Bergnes, Alexander Muci, Darren T. Hwee, Luke W. Ashcraft, Donghong Xu, Julia Schaletzky, Marc Garard, Ellen Valkevich, Nickie Durham, Pu-Ping Lu, Fady I. Malik, Chris R. Jamison, Scott Collibee, Wenyue Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:14930-14941
The discovery of reldesemtiv, a second-generation fast skeletal muscle troponin activator (FSTA) that increases force production at submaximal stimulation frequencies, is reported. Property-based optimization of high throughput screening hit 1 led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668cbb454d32e106e7cbf776cf29af68
https://doi.org/10.1021/acs.jmedchem.1c01067
https://doi.org/10.1021/acs.jmedchem.1c01067
Autor:
Laura A. Robertson, Julia Schaletzky, Xiaolin Wang, Chihyuan Chuang, Yangsong Wu, James J. Hartman, Jingying Wang, Eddie Wehri, Eva R. Chin, Fady I. Malik, Scott Collibee, Mark Vander Wal, Jeanelle Zamora, Peadar Cremin, Morgan Bradley P, Luke W. Ashcraft, Darren T. Hwee, Wenyue Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:14142-14152
Hypercontractility of the cardiac sarcomere may be essential for the underlying pathological hypertrophy and fibrosis in genetic hypertrophic cardiomyopathies. Aficamten (CK-274) is a novel cardiac myosin inhibitor that was discovered from the optimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57e158c743a4bf8ac97172694a8e35d
https://doi.org/10.1021/acs.jmedchem.1c01290
https://doi.org/10.1021/acs.jmedchem.1c01290
Autor:
Ashley N. Sharpe, Maureen S. Oldach, Joanna L. Kaplan, Victor Rivas, Samantha L. Kovacs, Darren T. Hwee, Bradley P. Morgan, Fady I. Malik, Samantha P. Harris, Joshua A. Stern
Publikováno v:
Journal of veterinary pharmacology and therapeuticsREFERENCES.
Hypertrophic cardiomyopathy (HCM) is the most prevalent cardiac disease in cats and lacks efficacious preclinical pharmacologic intervention, prompting investigation of novel therapies. Genetic mutations encoding sarcomeric proteins are implicated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9980902be46204dbe3beed577d36ed
https://pubmed.ncbi.nlm.nih.gov/36382714
https://pubmed.ncbi.nlm.nih.gov/36382714
Autor:
Ashley N, Sharpe, Maureen S, Oldach, Victor N, Rivas, Joanna L, Kaplan, Ashley L, Walker, Samantha L, Kovacs, Darren T, Hwee, Peadar, Cremin, Bradley P, Morgan, Fady I, Malik, Samantha P, Harris, Joshua A, Stern
Publikováno v:
Scientific reports. 13(1)
Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiac disease in humans and cats and lacks efficacious pharmacologic interventions in the preclinical phase of disease. LV outflow tract obstruction (LVOTO) is commonly observed in H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a58dbe7cf39ac09e1f100be2d9126548
https://pubmed.ncbi.nlm.nih.gov/36593243
https://pubmed.ncbi.nlm.nih.gov/36593243
Autor:
Saswata Sankar Sarkar, James J. Hartman, Darren T. Hwee, Chihyuan Chuang, Peadar Cremin, Andre deRosier, Samantha Edell, Roshni Madhvani, Yangsong Wu, Lisette Yco, Jeanelle Zamora, Anne Murphy, Bradley P. Morgan, Fady I. Malik
Publikováno v:
Biophysical Journal. 122:122a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b49ab7795d43ec7ed50966524b63713
https://doi.org/10.1016/j.bpj.2022.11.828
https://doi.org/10.1016/j.bpj.2022.11.828
Autor:
Darren T Hwee, Adam Kennedy, Julie Ryans, Alan J Russell, Zhiheng Jia, Aaron C Hinken, David J Morgans, Fady I Malik, Jeffrey R Jasper
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96921 (2014)
Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease characterized by progressive motor neuron loss resulting in muscle atrophy, declining muscle function, and eventual paralysis. Patients typically die from respiratory failure 3 to 5 years
Externí odkaz:
https://doaj.org/article/2d8b4b2563864ca697b28f372dd39e3f
Autor:
Weikang Ma, Livija Medne, Henk Granzier, Josine M. de Winter, Sandra Donkervoort, Benno Küsters, Gwimoon Seo, Coen A.C. Ottenheijm, A. Reghan Foley, Nicol C. Voermans, Carsten G. Bönnemann, Jose R. Pinto, Peter M. Kekenes-Huskey, Erik-Jan Kamsteeg, Steven A. Moore, Payam Mohassel, Ying Hu, Martijn van de Locht, Darren T. Hwee, Thomas C. Irving, Leon Begthel, Stefan Conijn, Fady I. Malik, Colin Quinn, Kalyan Immadisetty
Publikováno v:
Journal of Clinical Investigation, 131
Journal of Clinical Investigation, 131(9):e145700. The American Society for Clinical Investigation
Journal of Clinical Investigation, 131, 9
J Clin Invest
van de Locht, M, Donkervoort, S, de Winter, J M, Conijn, S, Begthel, L, Kusters, B, Mohassel, P, Hu, Y, Medne, L, Quinn, C, Moore, S A, Foley, A R, Seo, G, Hwee, D T, Malik, F I, Irving, T, Ma, W, Granzier, H L, Kamsteeg, E-J, Immadisetty, K, Kekenes-Huskey, P, Pinto, J R, Voermans, N, Bönnemann, C G & Ottenheijm, C A C 2021, ' Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium ', Journal of Clinical Investigation, vol. 131, no. 9, e145700 . https://doi.org/10.1172/JCI145700
Journal of Clinical Investigation, 131(9):e145700. The American Society for Clinical Investigation
Journal of Clinical Investigation, 131, 9
J Clin Invest
van de Locht, M, Donkervoort, S, de Winter, J M, Conijn, S, Begthel, L, Kusters, B, Mohassel, P, Hu, Y, Medne, L, Quinn, C, Moore, S A, Foley, A R, Seo, G, Hwee, D T, Malik, F I, Irving, T, Ma, W, Granzier, H L, Kamsteeg, E-J, Immadisetty, K, Kekenes-Huskey, P, Pinto, J R, Voermans, N, Bönnemann, C G & Ottenheijm, C A C 2021, ' Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium ', Journal of Clinical Investigation, vol. 131, no. 9, e145700 . https://doi.org/10.1172/JCI145700
Troponin C (TnC) is a critical regulator of skeletal muscle contraction; it binds Ca(2+) to activate muscle contraction. Surprisingly, the gene encoding fast skeletal TnC (TNNC2) has not yet been implicated in muscle disease. Here, we report 2 famili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1847527335eb416e2c2cd14d60167c
http://hdl.handle.net/2066/233733
http://hdl.handle.net/2066/233733
Autor:
Lorenza Brocca, Roberto Bottinelli, Julien Gondin, Fady I. Malik, Alan H. Beggs, David Bendahan, Charlotte Gineste, Maria Antonietta Pellegrino, Josine M. de Winter, Darren T. Hwee, Tamara C. Borsboom, Elisa Minardi, Maira Rossi, Monique Bernard, Coen A.C. Ottenheijm
Publikováno v:
Human Molecular Genetics
Human Molecular Genetics, 2021, 30 (14), pp.1305-1320. ⟨10.1093/hmg/ddab112⟩
Human Molecular Genetics, Oxford University Press (OUP), 2021, ⟨10.1093/hmg/ddab112⟩
Human Molecular Genetics, Oxford University Press (OUP), 2021, 30 (14), pp.1305-1320. ⟨10.1093/hmg/ddab112⟩
Human Molecular Genetics, 30(14), 1305-1320. Oxford University Press
de Winter, J M, Gineste, C, Minardi, E, Brocca, L, Rossi, M, Borsboom, T, Beggs, A H, Bernard, M, Bendahan, D, Hwee, D T, Malik, F I, Pellegrino, M A, Bottinelli, R, Gondin, J & Ottenheijm, C A C 2021, ' Acute and chronic tirasemtiv treatment improves in vivo and in vitro muscle performance in actin-based nemaline myopathy mice ', Human Molecular Genetics, vol. 30, no. 14, pp. 1305-1320 . https://doi.org/10.1093/hmg/ddab112
Human Molecular Genetics, 2021, 30 (14), pp.1305-1320. ⟨10.1093/hmg/ddab112⟩
Human Molecular Genetics, Oxford University Press (OUP), 2021, ⟨10.1093/hmg/ddab112⟩
Human Molecular Genetics, Oxford University Press (OUP), 2021, 30 (14), pp.1305-1320. ⟨10.1093/hmg/ddab112⟩
Human Molecular Genetics, 30(14), 1305-1320. Oxford University Press
de Winter, J M, Gineste, C, Minardi, E, Brocca, L, Rossi, M, Borsboom, T, Beggs, A H, Bernard, M, Bendahan, D, Hwee, D T, Malik, F I, Pellegrino, M A, Bottinelli, R, Gondin, J & Ottenheijm, C A C 2021, ' Acute and chronic tirasemtiv treatment improves in vivo and in vitro muscle performance in actin-based nemaline myopathy mice ', Human Molecular Genetics, vol. 30, no. 14, pp. 1305-1320 . https://doi.org/10.1093/hmg/ddab112
Nemaline myopathy, a disease of the actin-based thin filament, is one of the most frequent congenital myopathies. To date, no specific therapy is available to treat muscle weakness in nemaline myopathy. We tested the ability of tirasemtiv, a fast ske
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28071b148962a4557ec1e6091974973
https://hal.science/hal-03451368
https://hal.science/hal-03451368