Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Darren S. Gray"'
Publikováno v:
Journal of Biomechanical Engineering. 126:552-558
We investigated the mechanotransduction pathway in endothelial cells between their nucleus and adhesions to the extracellular matrix. First, we measured nuclear deformations in response to alterations of cell shape as cells detach from a flat surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996f0d570da56f79255f29d8ce48282a
https://doi.org/10.1115/1.1800559
https://doi.org/10.1115/1.1800559
Publikováno v:
Journal of Biomedical Materials Research. :605-614
Adherent cells are strongly influenced by the mechanical aspects of biomaterials, but little is known about the cellular effects of spatial variations in these properties. This work describes a novel method to produce polymeric cell culture surfaces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06c5ca07629bdfc8765de8f45ea8c32
https://doi.org/10.1002/jbm.a.10585
https://doi.org/10.1002/jbm.a.10585
Publikováno v:
Proceedings of the National Academy of Sciences. 100:1484-1489
We describe an approach to manipulate and measure mechanical interactions between cells and their underlying substrates by using microfabricated arrays of elastomeric, microneedle-like posts. By controlling the geometry of the posts, we varied the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e878d13e3d06289f0207cf3377918ef
https://doi.org/10.1073/pnas.0235407100
https://doi.org/10.1073/pnas.0235407100
Publikováno v:
Lasers in Surgery and Medicine. 29:160-164
Background and Objective: Photothermal heating of mechanically deformed cartilage accelerates stress relaxation and results in sustained shape change. In this study, shape retention was measured in Nd:YAG laser reshaped porcine septal cartilage. Mate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47cf1ef68b32dc7bf7ea584cc194fc7a
https://doi.org/10.1002/lsm.1104
https://doi.org/10.1002/lsm.1104
Autor:
Celeste M. Nelson, Wendy Liu, Kiran Bhadriraju, Darren S. Gray, Christopher S. Chen, Colette J. Shen
Publikováno v:
Experimental cell research. 314(15)
Endothelial cell-cell contact via VE-cadherin plays an important role in regulating numerous cell functions, including proliferation. However, using different experimental approaches to manipulate cell-cell contact, investigators have observed both i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0756f5d079b97455f69db81cb888b0ad
https://pubmed.ncbi.nlm.nih.gov/18652824
https://pubmed.ncbi.nlm.nih.gov/18652824
Publikováno v:
BioMEMS and Biomedical Nanotechnology ISBN: 9780387255651
Cells exist within a complex and ever-changing environment, which includes soluble molecules such as growth factors, an extracellular matrix that includes adhesive proteins and carbohydrates, and other neighboring cells. They actively sense and respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b13ee1f7e5766d23bc4c7b46474bb1a6
https://doi.org/10.1007/978-0-387-25844-7_18
https://doi.org/10.1007/978-0-387-25844-7_18
Publikováno v:
Biosensorsbioelectronics. 19(12)
We present a novel microfabricated device to simultaneously and actively trap thousands of single mammalian cells in alignment with a planar microelectrode array. Thousands of 3 Ipm diameter trapping electrodes were fabricated within the bottom of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f39b911949d4b49b92a52da1443425a
https://pubmed.ncbi.nlm.nih.gov/14709396
https://pubmed.ncbi.nlm.nih.gov/14709396
Autor:
Christopher S. Chen, Darren S. Gray
Publikováno v:
Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology.
Arrays of precisely positioned cells have many potential applications in biotechnology and basic cell biology. We have created arrays of single cells using dielectrophoresis (DEP), the force on polarizable bodies in a non-uniform electric field. Char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8038467f831c0ccbec1e2224311d76b
https://doi.org/10.1109/iembs.2002.1106602
https://doi.org/10.1109/iembs.2002.1106602
Publikováno v:
Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology.
Understanding of how cells exert and respond to mechanical forces depends on the ability to measure the origin and magnitude of those forces at subcellular resolutions. We have developed a novel system to measure cell contractility by culturing cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d43efd69458006b9c420838113c18fc
https://doi.org/10.1109/iembs.2002.1106582
https://doi.org/10.1109/iembs.2002.1106582
Publikováno v:
2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.02EX578).
The binding of cell surface receptors to local bioactive ligands is the principal mechanism by which cells survey their microenvironment and accordingly modulate their behaviors, such as proliferation, differentiation, migration, and suicide. Using m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d728ec243c748f316e1c210fa4b4169
https://doi.org/10.1109/mmb.2002.1002273
https://doi.org/10.1109/mmb.2002.1002273