Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Darren S Dumlao"'
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59267 (2013)
Cardiolipin, a major component of mitochondria, is critical for mitochondrial functioning including the regulation of cytochrome c release during apoptosis and proper electron transport. Mitochondrial cardiolipin with its unique bulky amphipathic str
Externí odkaz:
https://doaj.org/article/ac26fe37413943a3bfb596cfcb31ab1a
Autor:
Than S. Kyaw, Chen Zhang, Moriah Sandy, Kai Trepka, Shenwei Zhang, Luis A. Ramirez Hernandez, Lorenzo Ramirez, Janice J.N. Goh, Kristie Yu, Vincent Dimassa, Elizabeth N. Bess, Jacob G. Brockert, Darren S. Dumlao, Jordan E. Bisanz, Peter J. Turnbaugh
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110122- (2024)
Summary: Drug efflux transporters are a major determinant of drug efficacy and toxicity. A canonical example is P-glycoprotein (P-gp), an efflux transporter that controls the intestinal absorption of diverse compounds. Despite a rich literature on th
Externí odkaz:
https://doaj.org/article/fb71a7d7907c423597107107ee38397e
Autor:
Harvey R. Herschman, Susan M. Fischer, Edward A. Dennis, Art Catapang, Carol Mikulec, Clara E. Magyar, Paul C. Norris, Darren S. Dumlao, Tomo-O Ishikawa, Jing Jiao
Pharmacologic and global gene deletion studies demonstrate that cyclooxygenase-2 (PTGS2/COX-2) plays a critical role in DMBA/TPA–induced skin tumor induction. Although many cell types in the tumor microenvironment express COX-2, the cell types in w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd2435fc347bc4275f74c20431768e88
https://doi.org/10.1158/1541-7786.c.6539956.v1
https://doi.org/10.1158/1541-7786.c.6539956.v1
Autor:
Harvey R. Herschman, Susan M. Fischer, Edward A. Dennis, Art Catapang, Carol Mikulec, Clara E. Magyar, Paul C. Norris, Darren S. Dumlao, Tomo-O Ishikawa, Jing Jiao
Skin F4/80+ macrophage from Cox-2deltaM (Cox-2flox/flox;LysMCre+) mice undergo effective targeted Cox-2 gene deletion. Macrophages were isolated from the skin of 7-9 week old Cox-2deltaM and Cox-2fl/fl mice that were treated one time with TPA to indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011606cc5cbb303e9bd1f3c01202692e
https://doi.org/10.1158/1541-7786.22511506
https://doi.org/10.1158/1541-7786.22511506
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 6, Pp 1015-1038 (2009)
Eicosanoids have been implicated in a vast number of devastating inflammatory conditions, including arthritis, atherosclerosis, pain, and cancer. Currently, over a hundred different eicosanoids have been identified, with many having potent bioactive
Externí odkaz:
https://doaj.org/article/b6961715007a44e09a8af81eaaa3b838
Autor:
David J. Maloney, Tony L. Yaksh, Ganesha Rai, Qinghao Xu, Matthew W. Buczynski, Spencer C. Wei, Ann M. Gregus, Anton Simeonov, Paul C. Norris, Darren S. Dumlao, Edward A. Dennis, Ajit Jadhav, Bethany Fitzsimmons
Publikováno v:
Pain, vol 159, iss 12
Although nonsteroidal anti-inflammatory drugs are the first line of therapeutics for the treatment of mild to moderate somatic pain, they are not generally considered to be effective for neuropathic pain. In the current study, direct activation of sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388f2852143f25b37c08eae33fba3510
https://doi.org/10.1097/j.pain.0000000000001373
https://doi.org/10.1097/j.pain.0000000000001373
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::305916b66a5263735660f0ebba77b454
https://doi.org/10.1096/fasebj.2020.34.s1.09590
https://doi.org/10.1096/fasebj.2020.34.s1.09590
Autor:
Jing Jiao, Tomo-o Ishikawa, Susan M. Fischer, Carol Mikulec, Clara E. Magyar, Harvey R. Herschman, Paul C. Norris, Art Catapang, Darren S. Dumlao, Edward A. Dennis
Publikováno v:
Molecular cancer research : MCR, vol 12, iss 11
Pharmacologic and global gene deletion studies demonstrate that cyclooxygenase-2 (PTGS2/COX-2) plays a critical role in DMBA/TPA–induced skin tumor induction. Although many cell types in the tumor microenvironment express COX-2, the cell types in w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ee28bdd001e66e741725a1cb520aca
https://doi.org/10.1158/1541-7786.mcr-14-0397-t
https://doi.org/10.1158/1541-7786.mcr-14-0397-t
Publikováno v:
Biochimica et biophysica acta, vol 1811, iss 11
Fatty acid-derived eicosanoids and N-acylethanolamines (NAE) are important bioactive lipid mediators involved in numerous biological processes including cell signaling and disease progression. To facilitate research on these lipid mediators, we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2980a703ee9dc0dfae934c4049a3dacf
https://doi.org/10.1016/j.bbalip.2011.06.005
https://doi.org/10.1016/j.bbalip.2011.06.005
Autor:
Damian T Ng, Kim E. Barrett, Christopher K. Glass, Hui Dong, Gregory S. Harmon, Edward A. Dennis, Darren S. Dumlao
Publikováno v:
Nature medicine
Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (encoded by Cftr) that impair its role as an apical chloride channel that supports bicarbonate transport. Individuals with cystic fibrosis show retained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a0c97b0b3c16137ed2cc3ba296dbc8
https://doi.org/10.1038/nm.2101
https://doi.org/10.1038/nm.2101