Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Darren R. Shafren"'
Autor:
Jia Liu, Timothy Price, Mark Wong, Rafid Al-Asady, Eugene Hsu, Niall Tebbutt, Darren R Shafren, Naomi Croll
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/892a68eecbaa4f549180dea36daeefeb
Autor:
Margaret A. Knowles, Gough G. Au, Carla S. Möller-Levet, David Mansfield, Alan Melcher, Richard G. Vile, Nicola E. Annels, Darren R. Shafren, M. Denyer, Rachel E. Butler, Guy Simpson, Kevin J. Harrington, Mehreen Arif, Hardev Pandha
Publikováno v:
Molecular Therapy: Oncolytics, Vol 9, Iss, Pp 1-12 (2018)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
As a clinical setting in which local live biological therapy is already well established, non-muscle invasive bladder cancer (NMIBC) presents intriguing opportunities for oncolytic virotherapy. Coxsackievirus A21 (CVA21) is a novel intercellular adhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143771f9c416264d04f291837bdaa643
https://doi.org/10.1016/j.omto.2018.02.001
https://doi.org/10.1016/j.omto.2018.02.001
Autor:
Heather Powell, Joanne Smart, Lisa G Wood, Terry Grissell, Darren R Shafren, Michael J Hensley, Peter G Gibson
Publikováno v:
PLoS ONE, Vol 3, Iss 3, p e1802 (2008)
BackgroundThe common cold questionnaire (CCQ) is used to discriminate those with and without a viral infection. Its usefulness in people with acute asthma is unknown. Our aim was to assess the ability of the CCQ to detect viral infection and to monit
Externí odkaz:
https://doaj.org/article/8927b832b0b940cabc3cebb7e769e648
Autor:
Ann W. Silk, Bernard A. Fox, Jacqueline Norrell, Praveen K. Bommareddy, Jennifer L. Bryan, Daniella E Portal, Janice M. Mehnert, Seymour Fein, Joshua A. Vieth, Casey Imbergamo, Leslie Guerreiro, Cai Wu, Edwin Zambrano-Acosta, Steven J. O'Day, Andrew Zloza, Carmen Ballesteros-Merino, Marisa Palmeri, Howard L. Kaufman, Mark Grose, Daniel J. Medina, Darren R. Shafren
Publikováno v:
Cancer Research. 81:CT139-CT139
Background: Coxsackievirus A21 (V937) is an RNA oncolytic virus targeting ICAM-1 receptors. Pharmacodynamic effects of oncolytic viruses in the tumor microenvironment (TME), including increased CD8+ T cells and PD-L1 expression, support their use in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::804ad9974cf0aaa5c7a829869f200fb6
https://doi.org/10.1158/1538-7445.am2021-ct139
https://doi.org/10.1158/1538-7445.am2021-ct139
Autor:
Nicola E. Annels, Richard G. Vile, Mehreen Arif, M. Denyer, Darren R. Shafren, Izhar Bagwan, Carmen Ballesteros-Merino, Bernard A. Fox, Bronwyn Davies, Guy Simpson, Hardev Pandha, Gough G. Au, David Mansfield, Kevin J. Harrington, Mark Grose, Sarbjinder S Sandhu, Hugh Mostafid, Alan Melcher
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(19)
Purpose: The CANON [CAVATAK in NON–muscle-invasive bladder cancer (NMIBC)] study evaluated a novel ICAM-1–targeted immunotherapeutic-coxsackievirus A21 as a novel oncolytic agent against bladder cancer. Patients and Methods: Fifteen patients enro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50a2ced4ebc568bdd7895699b807ea6
https://pubmed.ncbi.nlm.nih.gov/31273010
https://pubmed.ncbi.nlm.nih.gov/31273010
Autor:
Jon M. Richards, Mark Grose, Mark B. Faries, Robert H.I. Andtbacka, Brendan D. Curti, Darren R. Shafren, Greg Daniels, Sigrun Hallmeyer
Publikováno v:
Cancer Research. 77:CT114-CT114
Background: CAVATAKTM is a novel bio-selected oncolytic and immunotherapeutic strain of Coxsackievirus A21 (CVA21). In a phase 2 study, intratumoral (i.t.) CVA21 injection of advanced melanoma lesions resulted in increases in tumor immune-cell infilt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a59d3d3243d0799dab1b6ff266990c91
https://doi.org/10.1158/1538-7445.am2017-ct114
https://doi.org/10.1158/1538-7445.am2017-ct114
Autor:
Hardev Pandha, Jonathan E. Rosenberg, Kevin J. Harrington, Alan Melcher, Rachael E. Sandborn, C Ralph, Sumati Gupta, David Ross Kaufman, Darren R. Shafren, Emmett V. Schmidt, Wallace Akerley, Mark Grose, Charles M. Rudin
Publikováno v:
Cancer Research. 77:CT115-CT115
Background: Coxsackievirus A21 (CVA21, CAVATAK) is a naturally occurring ICAM-1 targeted oncolytic immunotherapeutic virus. Pembrolizumab is a human programmed death receptor-1 (PD-1) blocking antibody that has yielded significant solid tumor respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::460057be281f40d5fa86440703a7cd39
https://doi.org/10.1158/1538-7445.am2017-ct115
https://doi.org/10.1158/1538-7445.am2017-ct115
Autor:
Terry V. Grissell, Darren R. Shafren, Bruce Whitehead, Lisa Wood, Michael J. Hensley, Peter G. Gibson, Bronwyn Davies, Heather Powell
Publikováno v:
Respirology. 16:291-299
Background and objective: Viral nucleic acid may be detected for up to 6 months after an acute asthma deterioration, but the pattern and consequences of viral persistence after acute asthma are incompletely understood. This study investigates the fre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d60ce6207d8d0fed58e3c1657fadd9e
https://doi.org/10.1111/j.1440-1843.2010.01897.x
https://doi.org/10.1111/j.1440-1843.2010.01897.x
Publikováno v:
Investigational New Drugs. 30:568-581
Virotherapy is an emerging strategy for the treatment of cancer that utilizes both replication-competent and genetically modified viruses to selectively kill tumor cells. We have previously shown that Coxsackievirus A21 (CVA21), a common-cold produci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c5f33cf1a70ab1558681961cdf1660
https://doi.org/10.1007/s10637-010-9614-0
https://doi.org/10.1007/s10637-010-9614-0
Autor:
Hardev Pandha, Rachel E. Sanborn, M.R. Zibelman, R. Jennens, Charles M. Rudin, Timothy D. Clay, Gavin M. Wright, Christy Ralph, Steven J. O'Day, Emmett V. Schmidt, Sumati Gupta, Mark Grose, Brendan D. Curti, Wallace Akerley, Darren R. Shafren, David Campbell, Jonathan E. Rosenberg, A.G. Hill, David E. Gerber, D. Day
Publikováno v:
Annals of Oncology. 29:viii732
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3959000b8294ab25ea99b71b1bf512de
https://doi.org/10.1093/annonc/mdy424.050
https://doi.org/10.1093/annonc/mdy424.050