Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Darren R. Gullick"'
Autor:
Mark Hewitt, Yi Sun, Simon Wilkinson, Gary P. Moss, Roderick Adams, Darren R. Gullick, Neil Davey
Publikováno v:
Journal of Pharmacy and Pharmacology. 72:873-888
Objectives The current study aims to determine the effect of physicochemical descriptor selection on models of polydimethylsiloxane permeation. Methods A total of 2942 descriptors were calculated for a data set of 77 chemicals. Data were processed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7922f6c2dae32a34b2c7f9ee4519303
https://doi.org/10.1111/jphp.13263
https://doi.org/10.1111/jphp.13263
Autor:
Brian S. Cummings, James V. Bruckner, Tanzir Mortuza, Catherine A. White, Darren R. Gullick, Srinivasa Muralidhara, Chen Chen
Publikováno v:
Toxicological Sciences. 162:327-336
There is increasing concern that infants and children may be at increased risk of neurological effects of pyrethroids, the most widely used class of insecticide. The objectives of this investigation were to (1) characterize the dose-dependent toxicok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334119f1060c76180fe0b9a7e81b4b0a
https://doi.org/10.1093/toxsci/kfx260
https://doi.org/10.1093/toxsci/kfx260
Autor:
Darren R. Gullick, Mona Hamdy Abdel Rahman, Tanzir Mortuza, Michael R. Linzey, Catherine A. White, Clinton A. Rogers, James V. Bruckner, Shirin Hooshfar, Michael G. Bartlett
Publikováno v:
Journal of Chromatography B. 1060:291-299
A sensitive method for the simultaneous determination of cis-permethrin (cis-PERM) and trans-permethrin (trans-PERM) in small volumes (100μL) of rat plasma and brain homogenate was developed, using a liquid-liquid extraction for sample preparation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbba1bc6f68a60ac253c50883af539d3
https://doi.org/10.1016/j.jchromb.2017.06.019
https://doi.org/10.1016/j.jchromb.2017.06.019
Autor:
Yi, Sun, Mark, Hewitt, Simon C, Wilkinson, Neil, Davey, Roderick G, Adams, Darren R, Gullick, Gary P, Moss
Publikováno v:
The Journal of pharmacy and pharmacologyReferences. 72(7)
The current study aims to determine the effect of physicochemical descriptor selection on models of polydimethylsiloxane permeation.A total of 2942 descriptors were calculated for a data set of 77 chemicals. Data were processed to remove redundancy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db1fcbc9cda877690f4edf882939ed3e
https://pubmed.ncbi.nlm.nih.gov/32246470
https://pubmed.ncbi.nlm.nih.gov/32246470
Publikováno v:
Analytical Methods. 9:1112-1118
Dimethyl sulfate (DMS) and monomethyl sulfate (MMS) are potential genotoxic impurities created during synthesis of some active pharmaceutical ingredients. While there are a few methods to determine the genotoxic compound DMS, the determination of MMS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b302aaa5a348ae0366acba22be2265fa
https://doi.org/10.1039/c7ay00044h
https://doi.org/10.1039/c7ay00044h
Publikováno v:
Biomedical Chromatography. 30:772-789
Reliable analytical methods are needed for the determination of pyrethroid pesticides residues in biological tissues such as whole blood and plasma, meat, eggs, milk, brain, liver, and adipose tissue for monitoring of levels in livestock and for huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1cc97ef20e185d02d519a2a87f692be
https://doi.org/10.1002/bmc.3712
https://doi.org/10.1002/bmc.3712
Autor:
Michael G. Bartlett, Shirin Hooshfar, Michael R. Linzey, James V. Bruckner, Catherine A. White, Clinton A. Rogers, Tanzir Mortuza, Darren R. Gullick
Publikováno v:
Rapid communications in mass spectrometry : RCM. 31(19)
RATIONALE Transfluthrin is a relatively non-toxic rapid-acting synthetic pyrethroid insecticide. It is widely used in household and hygiene products. A sensitive and accurate bioanalytical method is required for quantification of its concentration in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4cfe37990d3c05bf619738964e043c
https://pubmed.ncbi.nlm.nih.gov/28708331
https://pubmed.ncbi.nlm.nih.gov/28708331
Autor:
Graham A. Mills, Janine Brümmer, Mark A. Whittaker, Michael Eiden, Dennis K. Pearl, Mojgan Masoodi, Janis K. Shute, Philip C. Calder, Tricia M. McKeever, Harriet Nitch-Smith, Timothy M Trebble, James Brown, Darren R. Gullick
Publikováno v:
Journal of Crohn's and Colitis. 8:70-79
The polyunsaturated fatty acids (PUFA) arachidonic acid (AA, n-6) and eicosapentaenoic acid (EPA, n-3) are precursors of eicosanoids and other lipid mediators which have critical roles in inflammation. The mediators formed from the different PUFA hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7f0227ca3786936491f4daf3444889
https://doi.org/10.1016/j.crohns.2013.03.013
https://doi.org/10.1016/j.crohns.2013.03.013
Autor:
James V. Bruckner, Brian S. Cummings, Tanzir Mortuza, Darren R. Gullick, Shirin Hooshfar, Srinivasa Muralidhara, Manoj Amaraneni, Catherine A. White, Jing Pang
Publikováno v:
Journal of pharmaceutical sciences. 106(8)
Permethrin, the most widely used household insecticide in the United States, is marketed as a mixture of its cis (CIS) and trans (TRANS) isomers. The major objective of this investigation is to develop and utilize a reliable approach to determine in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b70efe6b0945f9ad4469de21bab0eb3
https://pubmed.ncbi.nlm.nih.gov/28445697
https://pubmed.ncbi.nlm.nih.gov/28445697
This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for m
