Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Darren R Flower"'
Autor:
Isabel K Macdonald, Maria Harkiolaki, Lawrence Hunt, Timothy Connelley, A Victoria Carroll, Niall D MacHugh, Simon P Graham, E Yvonne Jones, W Ivan Morrison, Darren R Flower, Shirley A Ellis
Publikováno v:
PLoS Pathogens, Vol 6, Iss 10, p e1001149 (2010)
T cell receptor (TCR) recognition of peptide-MHC class I (pMHC) complexes is a crucial event in the adaptive immune response to pathogens. Peptide epitopes often display a strong dominance hierarchy, resulting in focusing of the response on a limited
Externí odkaz:
https://doaj.org/article/dc0bc3cc205e45e6bb0790896cba9fc0
Autor:
Simone A Joosten, Krista E van Meijgaarden, Pascale C van Weeren, Fatima Kazi, Annemieke Geluk, Nigel D L Savage, Jan W Drijfhout, Darren R Flower, Willem A Hanekom, Michèl R Klein, Tom H M Ottenhoff
Publikováno v:
PLoS Pathogens, Vol 6, Iss 2, p e1000782 (2010)
Tuberculosis (TB) is an escalating global health problem and improved vaccines against TB are urgently needed. HLA-E restricted responses may be of interest for vaccine development since HLA-E displays very limited polymorphism (only 2 coding variant
Externí odkaz:
https://doaj.org/article/7131a35e2dd241dda2087c4d374e973e
Autor:
Matthew N Davies, Jagadeesh Bayry, Elma Z Tchilian, Janakiraman Vani, Melkote S Shaila, Emily K Forbes, Simon J Draper, Peter C L Beverley, David F Tough, Darren R Flower
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e8084 (2009)
BACKGROUND:Adjuvants enhance or modify an immune response that is made to an antigen. An antagonist of the chemokine CCR4 receptor can display adjuvant-like properties by diminishing the ability of CD4+CD25+ regulatory T cells (Tregs) to down-regulat
Externí odkaz:
https://doaj.org/article/a811bbb759c14bd5aae21245dc5ab3c1
Autor:
Valerie A Walshe, Channa K Hattotuwagama, Irini A Doytchinova, Mailee Wong, Isabel K Macdonald, Arend Mulder, Frans H J Claas, Pierre Pellegrino, Jo Turner, Ian Williams, Emma L Turnbull, Persephone Borrow, Darren R Flower
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e8095 (2009)
Predictive models of peptide-Major Histocompatibility Complex (MHC) binding affinity are important components of modern computational immunovaccinology. Here, we describe the development and deployment of a reliable peptide-binding prediction method
Externí odkaz:
https://doaj.org/article/6c512875ea134bdf8f3599e92748472d
Publikováno v:
BMC Bioinformatics, Vol 20, Iss S6, Pp 1-11 (2019)
Abstract Background Human Cytomegalovirus (HCMV) is a ubiquitous herpesvirus affecting approximately 90% of the world population. HCMV causes disease in immunologically naive and immunosuppressed patients. The prevention, diagnosis and therapy of HCM
Externí odkaz:
https://doaj.org/article/11fd5b1ed0d246c2b08537112b0c0b82
Autor:
Darren R. Flower
Publikováno v:
Molecules, Vol 27, Iss 21, p 7624 (2022)
Faced with new and as yet unmet medical need, the stark underperformance of the pharmaceutical discovery process is well described if not perfectly understood. Driven primarily by profit rather than societal need, the search for new pharmaceutical pr
Externí odkaz:
https://doaj.org/article/1944a313f8854c63a9f416aca4e40992
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-3 (2020)
After publication of the original article [1], we were notified that legends of Fig. 1 and Fig. 2 have been swapped.
Externí odkaz:
https://doaj.org/article/7629c5b8cdba411680069054d922bacf
Publikováno v:
Journal of Immunology Research, Vol 2020 (2020)
West Nile Virus (WNV) causes a debilitating and life-threatening neurological disease in humans. Since its emergence in Africa 50 years ago, new strains of WNV and an expanding geographical distribution have increased public health concerns. There ar
Externí odkaz:
https://doaj.org/article/75611f07e7ac434c968e7ce1fbcac2b6
Publikováno v:
Interdisciplinary Sciences: Computational Life Sciences.
Virtual screening (VS) is a computational strategy that uses in silico automated protein docking inter alia to rank potential ligands, or by extension rank protein–ligand pairs, identifying potential drug candidates. Most docking methods use prefer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfa29dc241762a2f36830458ce994295
https://doi.org/10.1007/s12539-022-00546-8
https://doi.org/10.1007/s12539-022-00546-8
Publikováno v:
Post-genomic Approaches in Drug and Vaccine Development ISBN: 9781003339090
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a1b0adf41f29f9ae707bbbbc4da9dba
https://doi.org/10.1201/9781003339090-9
https://doi.org/10.1201/9781003339090-9
