Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Darren Qiancheng Tan"'
Autor:
Yuji Takihara, Ayako Nakamura-Ishizu, Darren Qiancheng Tan, Masahiro Fukuda, Takayoshi Matsumura, Mitsuhiro Endoh, Yuichiro Arima, Desmond Wai Loon Chin, Terumasa Umemoto, Michihiro Hashimoto, Hidenobu Mizuno, Toshio Suda
Publikováno v:
Blood Advances, Vol 3, Iss 15, Pp 2323-2327 (2019)
Externí odkaz:
https://doaj.org/article/060360589a834657966fc7dbd6b953b1
Autor:
Makiko Mochizuki-Kashio, Deng Jianwen, Toshio Suda, Takayoshi Matsumura, Desmond Wai Loon Chin, Darren Qiancheng Tan, Ayako Nakamura-Ishizu
Publikováno v:
Blood
Hematopoietic stem cells (HSC) rarely divide, rest in quiescence, and proliferate only upon stress hematopoiesis. The cytokine thrombopoietin (Thpo) has been perplexingly described to induce quiescence and promote self-renewal divisions in HSCs. To c
Publikováno v:
Biochemical and Biophysical Research Communications. 534:843-848
Multiple myeloma (MM) is an intractable hematological malignancy characterized by abnormal plasma cells in the bone marrow (BM) and increased osteolytic lesions. Within the BM niche, mesenchymal stem cells (MSCs) have been proposed to contribute to f
Autor:
Malini Rethnam, Darren Qiancheng Tan, Shi Hao Tan, Jia Li, Rui Yokomori, Ying Li, Henry Yang, Takaomi Sanda, Toshio Suda
Publikováno v:
Blood advances. 6(18)
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy with poor clinical outcomes. Dysregulated MYC expression, which is associated with protein arginine methyltransferase 5 (PRMT5) dependency, is a recu
Publikováno v:
IRC-SET 2020 ISBN: 9789811594717
Multiple myeloma (MM) is the second most prevalent blood cancer in Singapore. Although the BH3-mimetic Venetoclax is effective against MM, acquired drug resistance occurs due to a shift in the balance between the activities of pro- and anti-apoptotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8697de21673131f9c6e78797d1d0aac
https://doi.org/10.1007/978-981-15-9472-4_8
https://doi.org/10.1007/978-981-15-9472-4_8
Autor:
Ayako Nakamura-Ishizu, Toshio Suda, Norio Asou, Kenji Tokunaga, Darren Qiancheng Tan, Touati Benoukraf, Takayoshi Matsumura, Tsukasa Okuda, Chelsia Qiuxia Wang, Siva Sai Naga Anurag Muddineni, Roberto Tirado-Magallanes, Motomi Osato, Masao Matsuoka, Stephanie Sian
Publikováno v:
Blood. 136(17)
RUNX1 is among the most frequently mutated genes in human leukemia, and the loss or dominant-negative suppression of RUNX1 function is found in myelodysplastic syndrome and acute myeloid leukemia (AML). How posttranslational modifications (PTMs) of R
Autor:
Darren Qiancheng Tan, Toshio Suda
Publikováno v:
Antioxidants & Redox Signaling. 29:149-168
The precise role and impact of reactive oxygen species (ROS) in stem cells, which are essential for lifelong tissue homeostasis and regeneration, remain of significant interest to the field. The long-term regenerative potential of a stem cell compart
Publikováno v:
Blood. 138:1132-1132
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is an aggressive hematologic cancer that stems from plasmacytoid dendritic cells (pDCs) and predisposes to leukemic transformation. Other than Tagraxofusp-erzs, a recently approved targeted therapy
Autor:
Yuichiro Arima, Masahiro Fukuda, Ayako Nakamura-Ishizu, Toshio Suda, Darren Qiancheng Tan, Desmond Wai Loon Chin, Michihiro Hashimoto, Yuji Takihara, Mitsuhiro Endoh, Hidenobu Mizuno, Terumasa Umemoto, Takayoshi Matsumura
Key Points HSCs can be separated based on high or low mitochondrial mass. Higher mitochondrial mass is associated with quiescence and greater reconstitution capacity of HSCs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cce39d5bc9ea38190f257371be14455
https://europepmc.org/articles/PMC6692999/
https://europepmc.org/articles/PMC6692999/
Publikováno v:
Blood. 136:13-13
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and clinically aggressive hematologic cancer that arises from malignant transformation of plasmacytoid dendritic cells (pDCs) and is predisposed to leukemic transformation. Apart from the