Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Darren Poole"'
Publikováno v:
Box, J R, Avanthay, M E, Poole, D L & Lennox, A J J 2023, ' Electronically Ambivalent Hydrodefluorination of Aryl-CF3 groups enabled by Electrochemical Deep-Reduction on a Ni Cathode ', Angewandte Chemie-International Edition, vol. 62, no. 12, e202218195 . https://doi.org/10.1002/anie.202218195
The Ar-CF2H moiety is featured in an increasing number of bioactive compounds due to its unique combination of properties. The hydrodefluorination of Ar-CF3 compounds is a direct and efficient route toward this motif. As reported methods for this tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff53b9ddc801aed43b6ee469aa905dd7
https://research-information.bris.ac.uk/en/publications/49726368-33bc-4bda-a381-5f10f739801b
https://research-information.bris.ac.uk/en/publications/49726368-33bc-4bda-a381-5f10f739801b
Herein we report the decarboxylative Minisci heteroarylation of bicyclo[1.1.1]pentane (BCP) derivatives at the C2 (bridge) position. The developed process directly couples free BCP C2-carboxylic acids with non-prefunctionalised heteroarenes to provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7cec8f5bf12b2c277be45e23a34ea1
https://doi.org/10.26434/chemrxiv-2022-vld15
https://doi.org/10.26434/chemrxiv-2022-vld15
Autor:
Kevin Lam, Matthew Leech, Dmitrii Nagornii, Jamie Walsh, Cyrille Kiaku, Darren Poole, Joseph Mason, Iain Goodall, Perry Devo
A new practical electrochemical method for the rapid, safe, and mild synthesis of tertiary hindered alkyl fluorides from easily accessed carboxylic acids has been developed without the need for hydrofluoric acid derivatives or non-glass reactors. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d097875bd0adb0862c9234d809ad187
https://doi.org/10.26434/chemrxiv-2022-b1v2c
https://doi.org/10.26434/chemrxiv-2022-b1v2c
Publikováno v:
Organic & Biomolecular Chemistry. 21:221-222
Guest Editors Kevin Lam, Shelley D. Minteer and Darren L. Poole introduce the Organic & Biomolecular Chemistry themed issue on synthetic electrochemistry.
Autor:
Samuel David Lee Holman, Neal Fazakerley, Darren poole, Diane M. Coe, Leonard Berlouis, Marc Reid
An electrochemical method for the green and practical synthesis of a broad range of substituted isoxazoline cores is presented. Both aryl and more challenging alkyl aldoximes are converted to the desired isoxazoline via an electrochemically enabled r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baf8e60690e0e86b52942a7b23ccb8f
https://doi.org/10.26434/chemrxiv.13480263.v1
https://doi.org/10.26434/chemrxiv.13480263.v1
Fluorinated alkyl groups are important motifs in bioactive compounds, positively influencing pharmacokinetics, potency and F conformation. The oxidative difluorination of alkenes represents an H important strategy for their preparation, yet current m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ba7dc7fa08b6400f90abaa62cd5b16
https://doi.org/10.26434/chemrxiv.9974687.v1
https://doi.org/10.26434/chemrxiv.9974687.v1