Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Darren P. Casey"'
Autor:
Kristen D. Turner, Ana Kronemberger, Dam Bae, Joshua M. Bock, William E. Hughes, Kenichi Ueda, Andrew J. Feider, Satoshi Hanada, Luis G. O. de Sousa, Matthew P. Harris, Ethan J. Anderson, Sue C. Bodine, M. Bridget Zimmerman, Darren P. Casey, Vitor A. Lira
Publikováno v:
Nutrients, Vol 14, Iss 21, p 4479 (2022)
Nitric oxide (NO) stimulates mitochondrial biogenesis in skeletal muscle. However, NO metabolism is disrupted in individuals with type 2 diabetes mellitus (T2DM) potentially contributing to their decreased cardiorespiratory fitness (i.e., VO2max) and
Externí odkaz:
https://doaj.org/article/f0c4a9ef66794e1fb98cdb528fdffe87
Autor:
Joshua M. Bock, William E. Hughes, Kenichi Ueda, Andrew J. Feider, Satoshi Hanada, Darren P. Casey
Publikováno v:
Physiological Reports, Vol 9, Iss 5, Pp n/a-n/a (2021)
Abstract Microvascular endothelial dysfunction precipitates cardiovascular disease mortality in patients with type 2 diabetes mellitus (T2DM). However, the relationship between glycemic management and microvascular endothelial function of these patie
Externí odkaz:
https://doaj.org/article/f0e6e48dd2f14c91be99827c73b09415
Autor:
Darren P. Casey, Mike eJoyner
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
We previously demonstrated that acute hypoperfusion in exercising human muscle causes an immediate increase in vascular resistance that is followed by a partial restoration (less than 100% recovery) of flow. In the current study we examined the contr
Externí odkaz:
https://doaj.org/article/3df86133703049f7a1977f4adacc90c4
Autor:
Joshua M. Bock, Brady E. Hanson, Kayla A. Miller, Nathanael T. Seaberg, Kenichi Ueda, Andrew J. Feider, Satoshi Hanada, Vitor A. Lira, Darren P. Casey
Publikováno v:
Journal of Applied Physiology. 133:1407-1414
We report that increasing nitric oxide bioavailability via 8 wk of inorganic nitrate/nitrite supplementation improves maximal aerobic exercise capacity in patients with type 2 diabetes mellitus. Similarly, we observed a rightward shift in the gas exc
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 323:R787-R796
Intermittent (IH), as opposed to continuous hypoxia (CH), is thought to have beneficial effects on cardiovascular function and health. In the present study, we examined the acute effects of IH and CH (∼80% pulse oxygen saturation via 10% oxygen tan
Publikováno v:
Nutr Metab Cardiovasc Dis
BACKGROUND & AIMS: Peripheral artery disease (PAD) is characterized by elevated blood pressure (BP), low nitric oxide availability (NO), and exaggerated pressor responses to sympatho-excitatory stressors. Inorganic nitrate reduces peripheral BP in he
Publikováno v:
Nitric Oxide. 118:17-25
AIMS Patients with type 2 diabetes mellitus (T2DM) have reduced vasodilatory responses during exercise partially attributable to low nitric oxide (NO) levels. Low NO contributes to greater α-adrenergic mediated vasoconstriction in contracting skelet
Autor:
Erika Iwamoto, Kenichi Ueda, Joshua M. Bock, Meredith J Luttrell, Kenzie Temperly, Satoshi Hanada, Andrew J. Feider, Benjamin R. Mardis, Darren P. Casey
Publikováno v:
Journal of Aging and Physical Activity. 29:423-430
The balance of angiogenic factors, including vascular endothelial growth factor (VEGF), and angiostatic factors, like thrombospondin-1 (TSP-1) and endostatin, controls striated muscle angiogenic responses to exercise training. The effect of age on ci
Autor:
Jem L. Cheng, Tom G. Bailey, Travis D. Gibbons, Stefanie L. Ruediger, Molly M. Baldwin, Joshua C. Tremblay, Dimitri W. Papadedes, Jay M. J. R. Carr, Karen M. Birch, Maureen J. MacDonald, Joshua M Bock, Kaitlyn D. Lee, Brady E. Hanson, Stephen J. Ives, Sachin B. Amin, Justin S. Lawley, Gemma K. Lyall, Alexander B. Hansen, Kate N. Thomas, Jennifer S. Williams, Darren P. Casey, Trevor J. King
Publikováno v:
Journal of Applied Physiology. 130:1155-1160
Autor:
Joshua M. Bock, Darren P. Casey
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 320:H991-H998
Aging causes deleterious changes in resting conduit artery shear patterns and reduced blood flow during exercise partially attributable to reduced nitric oxide (NO). Inorganic nitrate increases circulating NO bioavailability and may, therefore, impro