Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Darren P. Baker"'
Autor:
Krista Barclay, Robert Carruthers, Anthony Traboulsee, Ann D. Bass, Christopher LaGanke, Antonio Bertolotto, Aaron Boster, Elisabeth G. Celius, Jérôme de Seze, Dionisio Dela Cruz, Mario Habek, Jong-Mi Lee, Volker Limmroth, Sven G. Meuth, Celia Oreja-Guevara, Patricia Pagnotta, Cindy Vos, Tjalf Ziemssen, Darren P. Baker, Bart Van Wijmeersch
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Multiple sclerosis (MS) is a chronic autoimmune neurological disease that typically affects young adults, causing irreversible physical disability and cognitive impairment. Alemtuzumab, administered intravenously as 2 initial courses of 12 mg/day (5
Externí odkaz:
https://doaj.org/article/5a2d464a5167440db92790a49c321afc
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The ubiquitin-like protein ISG15 can be covalently linked to cellular and viral proteins, but the consequences of this ‘ISGylation’ remain largely unknown. Here, Zhao et al.show that ISGylation of the influenza B virus nucleoprotein inhibits form
Externí odkaz:
https://doaj.org/article/43b757d7acbd47d3bdbf6796ccfb079c
Autor:
Marcin Stawowczyk, Shamoon Naseem, Valeria Montoya, Darren P. Baker, James Konopka, Nancy C. Reich
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT A balanced immune response to infection is essential to prevent the pathology and tissue damage that can occur from an unregulated or hyperactive host defense. Interferons (IFNs) are critical mediators of the innate defense to infection, and
Externí odkaz:
https://doaj.org/article/45378e4cce3b4a958df966f7cef87517
Autor:
Diana Saleiro, Swarna Mehrotra, Barbara Kroczynska, Elspeth M. Beauchamp, Pawel Lisowski, Beata Majchrzak-Kita, Tushar D. Bhagat, Brady L. Stein, Brandon McMahon, Jessica K. Altman, Ewa M. Kosciuczuk, Darren P. Baker, Chunfa Jie, Nadereh Jafari, Craig B. Thompson, Ross L. Levine, Eleanor N. Fish, Amit K. Verma, Leonidas C. Platanias
Publikováno v:
Cell Reports, Vol 11, Iss 4, Pp 605-617 (2015)
We provide evidence that the Unc-51-like kinase 1 (ULK1) is activated during engagement of the type I interferon (IFN) receptor (IFNR). Our studies demonstrate that the function of ULK1 is required for gene transcription mediated via IFN-stimulated r
Externí odkaz:
https://doaj.org/article/634475be033c4f94ad88728b9a41870d
Autor:
Cecile Riviere-Cazaux, Lucas P. Carlstrom, Bryan J. Neth, Ian E. Olson, Karishma Rajani, Masum Rahman, Samar Ikram, Moustafa A. Mansour, Bipasha Mukherjee, Arthur E. Warrington, Susan C. Short, Thomas von Zglinicki, Desmond A. Brown, Sandeep Burma, Tamar Tchkonia, Marissa J. Schafer, Darren J. Baker, Sani H. Kizilbash, James L. Kirkland, Terry C. Burns
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven durable salvage therapies for patients that have failed conventional treatments. Post-treatment, the latent gl
Externí odkaz:
https://doaj.org/article/c015455051d141358c38ab0af93970d0
Autor:
Camille Laliberté, Bianca Bossé, Véronique Bourdeau, Luis I. Prieto, Genève Perron-Deshaies, Nhung Vuong-Robillard, Sebastian Igelmann, Lisbeth Carolina Aguilar, Marlene Oeffinger, Darren J. Baker, Luc DesGroseillers, Gerardo Ferbeyre
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1089 (2024)
Senescent cells, which accumulate with age, exhibit a pro-inflammatory senescence-associated secretory phenotype (SASP) that includes the secretion of cytokines, lipids, and extracellular vesicles (EVs). Here, we established an in vitro model of sene
Externí odkaz:
https://doaj.org/article/f5e4307220324bb7a2aa874149e20fc2
Autor:
Janine H. van Ree, Karthik B. Jeganathan, Raul O. Fierro Velasco, Cheng Zhang, Ismail Can, Masakazu Hamada, Hu Li, Darren J. Baker, Jan M. van Deursen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract PTEN is a multifaceted tumor suppressor that is highly sensitive to alterations in expression or function. The PTEN C-tail domain, which is rich in phosphorylation sites, has been implicated in PTEN stability, localization, catalytic activit
Externí odkaz:
https://doaj.org/article/64e268e5f57c49279fbd7d64e638b41e
Autor:
Ines Sturmlechner, Chance C. Sine, Karthik B. Jeganathan, Cheng Zhang, Raul O. Fierro Velasco, Darren J. Baker, Hu Li, Jan M. van Deursen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
To develop therapeutics that selectively eliminate pathological senescent cells it is important to understand their survival mechanisms. Here, the authors show that senescent cells manage to survive by keeping p53 activity in check through multiple m
Externí odkaz:
https://doaj.org/article/acbe3fbfd0cd4e49ada168a6fd190c50
Autor:
Davis A. Englund, Alyssa Jolliffe, Zaira Aversa, Xu Zhang, Ines Sturmlechner, Ayumi E. Sakamoto, Julianna D. Zeidler, Gina M. Warner, Colton McNinch, Thomas A. White, Eduardo N. Chini, Darren J. Baker, Jan M. van Deursen, Nathan K. LeBrasseur
Publikováno v:
Molecular Metabolism, Vol 67, Iss , Pp 101652- (2023)
Recent work has established associations between elevated p21, the accumulation of senescent cells, and skeletal muscle dysfunction in mice and humans. Using a mouse model of p21 overexpression (p21OE), we examined if p21 mechanistically contributes
Externí odkaz:
https://doaj.org/article/d4615090d69c464288f4371a6d95f0e6
Autor:
Jiwon Oh, Sandra Vukusic, Klaus Tiel-Wilck, Jihad Said Inshasi, David Rog, Darren P Baker, Yelena Pyatkevich, Elizabeth M Poole, Patrick Vermersch
Publikováno v:
Journal of Central Nervous System Disease, Vol 13 (2021)
Background: Evidence suggests that efficacy and safety of disease-modifying treatments for multiple sclerosis may differ with age. We evaluate efficacy and safety of teriflunomide across age subgroups of patients from pooled clinical trials and real-
Externí odkaz:
https://doaj.org/article/bae437d4845649a39d713d3e19297f0e