Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Darren M. Moss"'
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Akademický článek
Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer
Autor: Elizabeth de Wolf, Marwan Ibrahim Abdullah, Stefanie M. Jones, Karen Menezes, Darren M. Moss, Falko P. Drijfhout, Sarah R. Hart, Clare Hoskins, Euan A. Stronach, Alan Richardson
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Pre-clinical and retrospective studies of patients using statins to reduce plasma cholesterol have suggested that statins may be useful to treat cancer. However, prospective clinical trials have yet to demonstrate significant efficacy. We ha
Externí odkaz: https://doaj.org/article/ba16009471344089ac5a439986164551
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2
Modelling the long-acting administration of anti-tuberculosis agents using PBPK: a proof of concept study
Autor: Darren M. Moss, Andrew Owen, Rajith K. R. Rajoli, Anthony T. Podany, Marco Siccardi, Susan Swindells, Charles Flexner
Publikováno v: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
Setting Anti-tuberculosis formulations necessitate uninterrupted treatment to cure tuberculosis (TB), but are characterised by suboptimal adherence, which jeopardises therapeutic efficacy. Long-acting injectable (LAI) formulations or implants could a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95490beb7fba792822ee3423158396ac
https://doi.org/10.5588/ijtld.17.0515
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3
Do genetic variations in proximal tubule transporters influence tenofovir-induced renal dysfunction? An exploratory study in a Ghanaian population
Autor: Richard Phillips, Darren M. Moss, Andrew Owen, Adeniyi Olagunju, Megan Neary, Fred Stephen Sarfo, David Chadwick
Publikováno v: The Journal of antimicrobial chemotherapy. 75(5)
Objectives To assess associations between polymorphisms within genes encoding proximal tubule transporters implicated in tenofovir renal clearance and kidney tubular dysfunction (KTD), chronic kidney disease (CKD) and individual biochemical parameter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41daafbb3cf38bcbef66bcc370c507e0
https://pubmed.ncbi.nlm.nih.gov/32060504
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4
The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery
Autor: Hannah Kinvig, Andrew Owen, Darren M. Moss, Clare Hoskins, Paul Curley
Publikováno v: EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
Expert Review of Gastroenterology & Hepatology
Introduction\ud Nano-scale formulations are being developed to improve the delivery of orally administered medicines, and the interactions between nanoformulations and the gastrointestinal luminal, mucosal and epithelial environment is currently bein
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a850203f0e4881ad8a1dab65a1b40de1
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5
Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies
Autor: Catia Marzolini, Darren M. Moss, Rajith K. R. Rajoli, Marco Siccardi
Publikováno v: Expert Opinion on Drug Metabolism & Toxicology. 11:1203-1217
Introduction: The pharmacokinetic properties of anti-infective drugs are a determinant part of treatment success. Pathogen replication is inhibited if adequate drug levels are achieved in target sites, whereas excessive drug concentrations linked to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b673cbf177704c79c47d806b58db01
https://doi.org/10.1517/17425255.2015.1037278
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6
Nanotechnologies in Pancreatic Cancer Therapy
Autor: Anthony D.M. Curtis, Ayesha Manzur, Clare Hoskins, Adeolu Oluwasanmi, Darren M. Moss
Publikováno v: Pharmaceutics, Vol 9, Iss 4, p 39 (2017)
Pharmaceutics
Pancreatic cancer has been classified as a cancer of unmet need. After diagnosis the patient prognosis is dismal with few surviving over 5 years. Treatment regimes are highly patient variable and often the patients are too sick to undergo surgical re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed15af5544cf2f4e4443c1a59587079
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7
Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate
Autor: Steve P. Rannard, Andrew Owen, Marco Siccardi, Steve Wring, Rajith K. R. Rajoli, Darren M. Moss, Melynda E. Watkins, Ryan Randolph, Seonghee Park, Paul L. Domanico, James J. Hobson
Publikováno v: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Tenofovir disoproxil fumarate (TDF), a prodrug of tenofovir, has oral bioavailability (25%) limited by intestinal transport (P-glycoprotein), and intestinal degradation (carboxylesterase). However, the influence of luminal pancreatic enzymes is not f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960d86ad95272ee9e418e4f9666e4b5b
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8
Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis
Autor: Nicholas Fisher, Ghaith Aljayyoussi, Paul M. O'Neill, Maria Lurdes Santos Cristiano, Peter Gibbons, Ashley J. Warman, Richard Amewu, W. David Hong, Gemma L. Nixon, Neil G. Berry, Giancarlo A. Biagini, Stephen A. Ward, Maxine Caws, Andrew V. Stachulski, Raman Sharma, Darren M. Moss, Sally Mead, Paul A. Stocks, Alison E. Shone, Pedro Horta, Alison Ardrey, Paul T. P. Bedingfield, Suet C. Leung
Publikováno v: Journal of medicinal chemistry
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
A high-throughput screen (HTS) was undertaken against the respiratory chain dehydrogenase component, NADH:menaquinone oxidoreductase (Ndh) of Mycobacterium tuberculosis (Mtb). The 11000 compounds were selected for the HTS based on the known phenothia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75eea3deff75a8df20d74c3435238d4b
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9
Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer
Autor: Euan A. Stronach, Elizabeth de Wolf, Falko P. Drijfhout, Sarah R. Hart, K. Menezes, Darren M. Moss, Marwan Ibrahim Abdullah, Alan Richardson, Stefanie M. Jones, Clare Hoskins
Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Pre-clinical and retrospective studies of patients using statins to reduce plasma cholesterol have suggested that statins may be useful to treat cancer. However, prospective clinical trials have yet to demonstrate significant efficacy. We have previo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ba18e6dfc90af16e611378473a0bf9
https://pubmed.ncbi.nlm.nih.gov/28710496
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10
Optimizing nanomedicine pharmacokinetics using physiologically based pharmacokinetics modelling
Autor: Darren M. Moss, Marco Siccardi
Publikováno v: British Journal of Pharmacology. 171:3963-3979
The delivery of therapeutic agents is characterized by numerous challenges including poor absorption, low penetration in target tissues and non-specific dissemination in organs, leading to toxicity or poor drug exposure. Several nanomedicine strategi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db1409bf1b4638fa0892ee8be665f9aa
https://doi.org/10.1111/bph.12604
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