Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Darren M. Griffith"'
Autor:
Aisling L. Ryan, Joshua Northcote-Smith, Aoife McKeon, Andrew Roe, Paul O'Dowd, Brendan Twamley, Triona Ní Chonghaile, Kogularamanan Suntharalingam, Darren M. Griffith
Publikováno v:
Dalton Transactions. 51:18127-18135
Hedgehog pathway inhibitor ligand enhances cytotoxicity of trans-Pt(ii) complex towards breast cancer stem cells and triple negative breast cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bccb1dcb9de6e3e2bd42159847ebbdf
https://doi.org/10.1039/d2dt02865d
https://doi.org/10.1039/d2dt02865d
Autor:
Aisling L, Ryan, Joshua, Northcote-Smith, Aoife, McKeon, Andrew, Roe, Paul, O'Dowd, Brendan, Twamley, Triona, Ní Chonghaile, Kogularamanan, Suntharalingam, Darren M, Griffith
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 51(47)
The first example of a Pt complex of GANT61, a hedgehog (Hh) pathway inhibitor is reported. Reaction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9f27dfce493756e05f241c12fa7813e
https://pubmed.ncbi.nlm.nih.gov/36382541
https://pubmed.ncbi.nlm.nih.gov/36382541
Autor:
Donal M. Keogan, Darren M. Griffith
Publikováno v:
Molecules, Vol 19, Iss 9, Pp 15258-15297 (2014)
Bismuth compounds have been used extensively as medicines and in particular for the treatment of gastrointestinal ailments. In addition to bismuth’s well known gastroprotective effects and efficacy in treating H. pylori infection it also has broad
Externí odkaz:
https://doaj.org/article/ceff217c7f734c12993930b6518c137e
Publikováno v:
Chemical Society Reviews. 50:12037-12069
Bismuth as a relatively non-toxic and inexpensive metal with exceptional properties has numerous biomedical applications. Bismuth-based compounds are used extensively as medicines for the treatment of gastrointestinal disorders including dyspepsia, g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4022fa78e3960355baeb184793e73829
https://doi.org/10.1039/d0cs00031k
https://doi.org/10.1039/d0cs00031k
Autor:
Donal M Keogan, Éva A. Enyedy, Brendan Twamley, Máté Kozsup, Péter Buglyó, Deirdre Fitzgerald-Hughes, Darren M. Griffith
Publikováno v:
Dalton Transactions. 49:6980-6988
The X-ray crystal structure and pKa values of GSK322, a well-known and effective peptide deformylase inhibitor and antibacterial drug candidate, are reported. The first examples of Co(iii) complexes of N-formyl hydroxylamines are reported. Reaction o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75072bdf1662d2fad7b6012a133270aa
https://doi.org/10.1039/d0dt01123a
https://doi.org/10.1039/d0dt01123a
Autor:
Brona M. Murphy, Darren M. Griffith, Aisling L Ryan, András Ozsváth, Marie-Claire Fitzgerald, Péter Buglyó, Brendan Twamley
Publikováno v:
Inorganic Chemistry. 58:16075-16086
GANT61-D is an important hedgehog pathway inhibitor and an interesting ligand candidate for metal coordination. The first examples of metal complexes of the potent hedgehog pathway inhibitor GANT61-D are described. The reaction of Ni(II), Pd(II), and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5975c030477afa9f739de99fe53c0e0a
https://doi.org/10.1021/acs.inorgchem.9b02632
https://doi.org/10.1021/acs.inorgchem.9b02632
Autor:
Anthony P. McHale, Mark Love, Darren M. Griffith, John F. Callan, Thomas McKaig, Keiran Logan, Jinhui Gao, Mark A. Taylor, Heather Nesbitt, Bridgeen Callan
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 338
FOLFIRINOX and FOLFOXIRI are combination chemotherapy treatments that incorporate the same drug cocktail (folinic acid, 5-fluorouracil, oxaliplatin and irinotecan) but exploit an altered dosing regimen when used in the management of pancreatic and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04989e29d4a4b9cc16c92a55225230be
https://pubmed.ncbi.nlm.nih.gov/34481018
https://pubmed.ncbi.nlm.nih.gov/34481018
Publikováno v:
Molecules, Vol 21, Iss 11, p 1550 (2016)
n/a
Externí odkaz:
https://doaj.org/article/02a0f463a6104079acee131e15b22eb2
Publikováno v:
Molecules, Vol 21, Iss 7, p 949 (2016)
We describe a novel improved approach to the synthesis of the important and well-known heat shock protein 70 inhibitor (HSP70), pifithrin-μ, with corresponding and previously unreported characterisation. The first example of a combination study comp
Externí odkaz:
https://doaj.org/article/70af6c3a556a402a8d3490d68b208116
Publikováno v:
Access Microbiology. 2
To human health worldwide. Existing treatments are becoming inefficacious and therefore there is an urgent need for the development of treatments with alternative modes of action. The use of gallium as an antimicrobial agent has been of interest due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d0bde09c0ea40b92f3505fb0d2b1720
https://doi.org/10.1099/acmi.ac2020.po0222
https://doi.org/10.1099/acmi.ac2020.po0222