Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Darren M Hutt"'
Autor:
Daniela Martino Roth, Darren M Hutt, Jiansong Tong, Marion Bouchecareilh, Ning Wang, Theo Seeley, Johanna F Dekkers, Jeffrey M Beekman, Dan Garza, Lawrence Drew, Eliezer Masliah, Richard I Morimoto, William E Balch
Publikováno v:
PLoS Biology, Vol 12, Iss 11, p e1001998 (2014)
Diseases of protein folding arise because of the inability of an altered peptide sequence to properly engage protein homeostasis components that direct protein folding and function. To identify global principles of misfolding disease pathology we exa
Externí odkaz:
https://doaj.org/article/a1806e3f4d0546f9a4f7421448cf23d1
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e106224 (2014)
Hypoxia inducible factor 1α (HIF-1α) is a master regulator of tumor angiogenesis being one of the major targets for cancer therapy. Previous studies have shown that Histone Deacetylase Inhibitors (HDACi) block tumor angiogenesis through the inhibit
Externí odkaz:
https://doaj.org/article/9998accd3a2143e298edbe1ec814faff
Autor:
Judith A Coppinger, Darren M Hutt, Abbas Razvi, Atanas V Koulov, Sandra Pankow, John R Yates, William E Balch
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37682 (2012)
Protein folding is the primary role of proteostasis network (PN) where chaperone interactions with client proteins determine the success or failure of the folding reaction in the cell. We now address how the Phe508 deletion in the NBD1 domain of the
Externí odkaz:
https://doaj.org/article/c58f48318e9d4af4b9a801a25a808a6e
Autor:
Salvatore Loguercio, Nicole Y. Farhat, Kanagaraj Subramanian, Pei Zhao, Darren M. Hutt, Forbes D. Porter, Samantha M. Scott, William E. Balch, Chao Wang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications
Nature communications, vol 10, iss 1
To understand the impact of epigenetics on human misfolding disease, we apply Gaussian-process regression (GPR) based machine learning (ML) (GPR-ML) through variation spatial profiling (VSP). VSP generates population-based matrices describing the spa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce12b071821cd1c210d9f9fb9b34a81
https://doaj.org/article/cdd46cddd7bd45bbba719375caab04d4
https://doaj.org/article/cdd46cddd7bd45bbba719375caab04d4
Autor:
Chao Wang, William E. Balch, Samantha M. Scott, Jason E. Gestwicki, Pei Zhao, Hao Shao, Darren M. Hutt, Shuhong Sun
Publikováno v:
Hum Mol Genet
Human molecular genetics, vol 29, iss 1
Human molecular genetics, vol 29, iss 1
Genetic diversity provides a rich repository for understanding the role of proteostasis in the management of the protein fold in human biology. Failure in proteostasis can trigger multiple disease states, affecting both human health and lifespan. Nie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3485d026aad5866014bcd48830c392f
https://doi.org/10.1093/hmg/ddz215
https://doi.org/10.1093/hmg/ddz215
Autor:
Nina R. Ortiz, Laura J. Blair, Marc B. Cox, Jeffrey C. Sivils, David S. Culbertson, Jane Dyson, Ashley N Payan, Dan Finley, Jazzmin Jovonna Owens, Jason E. Gestwicki, Szu Yu Kuo, William E. Balch, Jaideep Chaudhary, Jay Singh, Darren M. Hutt, Chad A. Dickey, Naihsuan Guy, Bradley D. Tait, Shravan Kumar Komaragiri
Publikováno v:
Cell chemical biology, vol 27, iss 3
Cell Chem Biol
Cell Chem Biol
Summary Hsp90 plays an important role in health and is a therapeutic target for managing misfolding disease. Compounds that disrupt co-chaperone delivery of clients to Hsp90 target a subset of Hsp90 activities, thereby minimizing the toxicity of pan-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c800b824e420391f461894a73274c69
https://escholarship.org/uc/item/3k55j4vx
https://escholarship.org/uc/item/3k55j4vx
Publikováno v:
Journal of Molecular Biology. 430:2951-2973
The advent of precision medicine for genetic diseases has been hampered by the large number of variants that cause familial and somatic disease, a complexity that is further confounded by the impact of genetic modifiers. To begin to understand differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a369d72be360050ed17fcf8e00cc3b
https://doi.org/10.1016/j.jmb.2018.06.017
https://doi.org/10.1016/j.jmb.2018.06.017
Autor:
Kanagaraj Subramanian, William E. Balch, Harold Ralph, Darren M. Hutt, Nina H. Pipalia, Frederick R. Maxfield, Shu Mao, Samantha M. Scott
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 4, Pp 695-708 (2017)
Niemann-Pick C (NPC) disease is an autosomal recessive disorder that leads to excessive storage of cholesterol and other lipids in late endosomes and lysosomes. The large majority of NPC disease is caused by mutations in NPC1, a large polytopic membr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02132b45b5c10165a28e161d8f720658
https://doi.org/10.1194/jlr.m072140
https://doi.org/10.1194/jlr.m072140
Autor:
Salvatore Loguercio, Alexander V. Misharin, Richard I. Morimoto, Ziyan Lu, Alexandra C. McQuattie-Pimentel, Hiam Abdala-Valencia, Thomas Stoeger, Karen M. Ridge, G. R. Scott Budinger, William E. Balch, Darren M. Hutt, Navdeep S. Chandel, Alexandre Rosa Campos, Nikita Joshi, Rogan A. Grant, Jacob I. Sznajder
Aging is associated with an increased risk for the development of many diseases. This is exemplified by the increased incidence of lung injury, muscle dysfunction and cognitive impairment in the elderly following influenza infection. Because the infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eeeb7eb3b81492b85c6f6487c1a6be0
https://doi.org/10.1101/769737
https://doi.org/10.1101/769737
Autor:
Samantha M. Scott, Darren M. Hutt, Kanagaraj Subramanian, Vijay Gupta, William E. Balch, Shu Mao
Publikováno v:
J Biol Chem
Niemann-Pick type C (NPC) disease is primarily caused by mutations in the NPC1 gene and is characterized by the accumulation of unesterified cholesterol and lipids in the late endosomal (LE) and lysosomal (Ly) compartments. The most prevalent disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce3c189c57a533df05bc6acab837e6d
https://pubmed.ncbi.nlm.nih.gov/32354745
https://pubmed.ncbi.nlm.nih.gov/32354745