Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Darren Locke"'
Autor:
Darren Locke, Clifford C. Hoyt
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Immunohistochemistry has long been held as the gold standard for understanding the expression patterns of therapeutically relevant proteins to identify prognostic and predictive biomarkers. Patient selection for targeted therapy in oncology has succe
Externí odkaz:
https://doaj.org/article/ef00cf64264048a687d0d7810a6db39f
Autor:
Peter Miller, Hailing Zong, Jasmine Singh, Darren Locke, Olive Shang, Judi Gordon, Nadya Nikulina, Sejal Mistry, Jessica Yuan, Trillium Blackmer, Oliver Braubach, Julia Kennedy-Darling
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/95e489bba51646e582c2b8271c464fcd
Autor:
Bernard A Fox, Chichung Wang, Kristin Roman, Carla Coltharp, Carmen Ballesteros-Merino, Shawn M Jensen, Janis M Taube, David L Rimm, Cliff Hoyt, Mei Jiang, Edwin R Parra, Ignacio Wistuba, Elizabeth L Engle, John McGuire, Bethany Remeniuk, Darren Locke
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Background Emerging data suggest predictive biomarkers based on the spatial arrangement of cells or coexpression patterns in tissue sections will play an important role in precision immuno-oncology. Multiplexed immunofluorescence (mIF) is ideally sui
Externí odkaz:
https://doaj.org/article/949449e6557a457d9c3e50a96e2a57b6
Autor:
Kara W Moyes, Amira Davis, Virginia Hoglund, Kristen Haberthur, Nicole AP Lieberman, Shannon A Kreuser, Gail H. Deutsch, Stephanie Franco, Darren Locke, Michael O Carleton, Debra G Gilbertson, Randi Simmons, Conrad Winter, John Silber, Luis F Gonzalez-Cuyar, Richard G Ellenbogen, Courtney A. Crane
Publikováno v:
OncoImmunology, Vol 7, Iss 11 (2018)
Efforts to reduce immunosuppression in the solid tumor microenvironment by blocking the recruitment or polarization of tumor associated macrophages (TAM), or myeloid derived suppressor cells (MDSCs), have gained momentum in recent years. Expanding ou
Externí odkaz:
https://doaj.org/article/d1144085ce0e412cb6807c0ebd1c77eb
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9a72d683094bb669b9b3e75c6de67c8
https://doi.org/10.1136/jitc-2022-sitc2022.0149
https://doi.org/10.1136/jitc-2022-sitc2022.0149
Autor:
Nicole Couper, Bethany Remeniuk, Karen McClymont, Bei Hopkins, Natalie Monteiro, Lorcan Sherry, Darren Locke
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b228173a7945c459c3120ac765f88e6
https://doi.org/10.1136/jitc-2022-sitc2022.0131
https://doi.org/10.1136/jitc-2022-sitc2022.0131
Autor:
Lorcan Sherry, Nicole Couper, Bethany Remeniuk, Karen McClymont, Bei Hopkins, Natalie Monteiro, Gabriel Reines March, Darren Locke
Publikováno v:
Cancer Research. 83:4633-4633
Non-small cell lung cancer (NSCLC) is a complex disease with varying pathological subtypes including adenocarcinomas and squamous cell carcinomas. After diagnosis, tumor staging provides important information about the extent of cancer in the body an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e92df757d85a536bfa82f847bfd8774
https://doi.org/10.1158/1538-7445.am2023-4633
https://doi.org/10.1158/1538-7445.am2023-4633
Autor:
Lei Zhao, Paul Whitehead, Lei Li, Mary Ellen Cvijic, Erica Cook, Akbar M. Siddiqui, Zhuyin Li, Darren Locke, Normand J. Cloutier, Dana E. Vanderwall, Youping Xiao, Larnie Myer, Holmes Derek A, Jia Peng, Richard W. Bishop, Shannon Hamilton
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Scientific Reports
Quantitatively determining in vivo achievable drug concentrations in targeted organs of animal models and subsequent target engagement confirmation is a challenge to drug discovery and translation due to lack of bioassay technologies that can discrim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9724a7b42ac240a9add9270f93ef94e
http://link.springer.com/article/10.1038/s41598-020-71347-6
http://link.springer.com/article/10.1038/s41598-020-71347-6
Autor:
Darren Locke, Matt Newgren, Murat Aksoy, Rachel Finck, Jay G. Tarolli, Jessica Finn, Yi Zhang, Mary-Ellen Cvijic, Zhuyin Li, Yari Sigal, Jason Ptacek
Publikováno v:
Laboratory Investigation. 100:1111-1123
An ability to characterize the cellular composition and spatial organization of the tumor microenvironment (TME) using multiplexed IHC has been limited by the techniques available. Here we show the applicability of multiplexed ion beam imaging (MIBI)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75f3d0ad3d8609f111e12321c950e41
https://doi.org/10.1038/s41374-020-0417-4
https://doi.org/10.1038/s41374-020-0417-4
Autor:
Ming Zhou, Ye Feng, Qiuyan Wu, Venkata Nagineni, Hongyu Zhao, Jose Luis Perez-Gracia, Jianlei Gu, Miguel F. Sanmamed, Shu-Pang Huang, Darren Locke, Vipul Baxi, Nicole Gianino, Timothy Baradet, Kurt A. Schalper, Penny Phillips, Tian Chen, Alice M. Walsh, Michael Carleton, Timothy P. Reilly, Ignacio Melero, Dimple Pandya
Publikováno v:
Nat Med
Serum interleukin-8 (IL-8) levels and tumor neutrophil infiltration are associated with worse prognosis in advanced cancers. Here, using a large-scale retrospective analysis, we show that elevated baseline serum IL-8 levels are associated with poor o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d331d2a10b6b18cdcddc65e357fd5d9
https://doi.org/10.1038/s41591-020-0856-x
https://doi.org/10.1038/s41591-020-0856-x