Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Darren L. Reid"'
Autor:
Phenil J. Patel, Marieta Duvnjak Romic, Dipal Patel, Margaret S. Landis, Darren L. Reid, Shobha N. Bhattachar, Wenzhan Yang
Publikováno v:
Drug Discovery Today. 26:713-723
Drug-delivery technologies for modified drug release have been in existence for decades, but their utilization has been largely limited to post-launch efforts improving therapeutic outcomes. Recently, they have gained renewed importance because the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26581814597c35f626a2fb9bc9865bce
https://doi.org/10.1016/j.drudis.2020.12.008
https://doi.org/10.1016/j.drudis.2020.12.008
Publikováno v:
Drug Discovery Today. 27:103366
Developability molecule assessment is a key interfacial capability across the biopharmaceutical industry, screening and staging molecules discovered by medicinal chemists for successful chemistry manufacturing controls (CMC) development and launch. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1df9dfff8509566f68aee6bfa3bd42
https://doi.org/10.1016/j.drudis.2022.103366
https://doi.org/10.1016/j.drudis.2022.103366
Autor:
Daniel G. Greene, Kaitlyn Wendl, Hyunsoo Park, Scott Sherman, Roman Shimanovich, Darren L. Reid, Prashant Agarwal, Leonela Vega
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 158
Sustained-release formulations are important tools to convert efficacious molecules into therapeutic products. Hydrogels enable the rapid assessment of sustained-release strategies, which are important during preclinical development where drug quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87e6649e55ffd81d909043e13380b32
https://pubmed.ncbi.nlm.nih.gov/33359482
https://pubmed.ncbi.nlm.nih.gov/33359482
Publikováno v:
Drug discovery today. 26(1)
Early prediction of elimination pathways for new chemical entities can have a profound impact on drug discovery programs. The recently proposed Extended Clearance Classification System (ECCS) is a step in the right direction, providing a framework to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e943336f75742e0cb814508a38d3228d
https://pubmed.ncbi.nlm.nih.gov/33075472
https://pubmed.ncbi.nlm.nih.gov/33075472
Autor:
Wenzhan Yang, Phenil J. Patel, Darren L. Reid, Margaret S. Landis, Pankajini Mallick, Dipal Patel, Manuel Sanchez-Felix, Venkata R. Krishnamurthy, Prajakta Gadgil
Publikováno v:
The AAPS journal. 22(2)
The druggability and developability space is rapidly evolving in the post-genomic era. In the past, Lipinski’s rule-of-five (Ro5) emerged and served as a guide for drug-like molecule design for oral delivery in the traditional druggable target spac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e54931b99e8a7668e1a4b093a6687f
https://pubmed.ncbi.nlm.nih.gov/31900602
https://pubmed.ncbi.nlm.nih.gov/31900602
Autor:
Qingyian Liu, Kaustav Biswas, Frank Koegler, Tiffany L. Correll, Toni Williamson, Jodi Bradley, Jennifer R. Allen, Leeanne Zalameda, Darren L. Reid, Michael D. Bartberger, Joe Zhu, Stephen J. Wood, Randy Hungate, Yichin Liu, Frank Chavez, Robert M. Rzasa, Jianhua Zhang, John D. McCarter, Thomas Nixey, Paul H. Wen, Li Zhu, Shannon Rumfelt, Yi Luo, Safura Babu-Khan, Stephen Hitchcock, Ning Chen, Mqhele Ncube, Wenyuan Qian, Frenel Fils Demorin, Dean Hickman, Christopher M. Tegley, Jian J. Chen, Albert Amegadzie, Charles W. Dean, Chester Chenguang Yuan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6447-6454
γ-Secretase modulators (GSMs) are potentially disease-modifying treatments for Alzheimer's disease. They selectively lower pathogenic Aβ42 levels by shifting the enzyme cleavage sites without inhibiting γ-secretase activity, possibly avoiding know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9717b5fcc1d773beec78fba83ce7ef
https://doi.org/10.1016/j.bmcl.2013.09.041
https://doi.org/10.1016/j.bmcl.2013.09.041
Publikováno v:
ADME-Enabling Technologies in Drug Design and Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::387a589a63132534eb2850812979843b
https://doi.org/10.1002/9781118180778.ch31
https://doi.org/10.1002/9781118180778.ch31
Autor:
Andrew Tasker, Pedro J. Beltran, Darren L. Reid, Robert Radinsky, Jian J. Chen, Dina A. Andrews, David J. St. Jean, Keegan Cooke, Ryan Wurz, Tian Wu, Nataraj Kalyanaraman, Essa Hu-Harrington, Faye Hsieh, Simon J. Hedley, Kristin L. Andrews, Brad Herberich, Nancy E. Everds, Seifu Tadesse, Michele Kubryk, Jinghui Zhan, Jason S. Tedrow, Kate Ashton, Petia Mitchell, Andrew T. Parsons, Roberto E. Guzman, Liping H. Pettus, James Brown, Dean Hickman, Tom Nguyen, Matthew S. Potter, Edward K. Lobenhofer, David Bauer, Fang-Tsao Hong, Oliver R. Thiel
Publikováno v:
ACS medicinal chemistry letters. 6(9)
In nonsmall cell lung cancer (NSCLC), the threonine(790)-methionine(790) (T790M) point mutation of EGFR kinase is one of the leading causes of acquired resistance to the first generation tyrosine kinase inhibitors (TKIs), such as gefitinib and erloti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c2a4761195d385ad7efb8de49ebaf6
https://pubmed.ncbi.nlm.nih.gov/26396685
https://pubmed.ncbi.nlm.nih.gov/26396685
Publikováno v:
Journal of Physical Organic Chemistry. 18:86-89
Unlike electrophilic carbenes, which react at sulfur to produce thiocarbonyl ylide intermediates, dimethoxycarbene (DMC), generated by thermolysis of an oxadiazoline at 110°C in benzene in a sealed tube, reacts at carbon, possibly to generate a zwit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c4deab091955f4206eac1ac4d89b7c7
https://doi.org/10.1002/poc.857
https://doi.org/10.1002/poc.857
Publikováno v:
The Journal of Physical Chemistry A. 108:2720-2725
Ab initio calculations at the B3LYP/6-31G(d) level and scaled particle theory, combined with entropies of activation derived from experimental Arrhenius A factors, were applied to examine the origin of the loss of gaseous-phase entropy of a substance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cea88bed603fb8a4fd50210b4473d7f
https://doi.org/10.1021/jp030265a
https://doi.org/10.1021/jp030265a