Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Darren L. Poole"'
Autor:
Graeme W. Carlile, Qi Yang, Elizabeth Matthes, Jie Liao, Véronique Birault, Helen F. Sneddon, Darren L. Poole, Callum J. Hall, John W. Hanrahan, David Y. Thomas
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Most cases of cystic fibrosis (CF) are caused by class 2 mutations in the cystic fibrosis transmembrane regulator (CFTR). These proteins preserve some channel function but are retained in the endoplasmic reticulum (ER). Partial rescue of the
Externí odkaz:
https://doaj.org/article/6c974b2051ad451a915f788a93fa1833
Autor:
Matthew C. Leech, Dmitrii Nagornîi, Jamie M. Walsh, Cyrille Kiaku, Darren L. Poole, Joseph Mason, Iain C. A. Goodall, Perry Devo, Kevin Lam
Publikováno v:
Organic Letters. 25:1353-1358
Autor:
Cyrille Kiaku, Jamie M. Walsh, Matthew C. Leech, Darren L. Poole, Joseph Mason, Iain C. A. Goodall, Perry Devo, Kevin Lam
Publikováno v:
Organic Letters. 25:1147-1150
Autor:
Aaron J. Day, Timothy C. Jenkins, Marvin Kischkewitz, Kirsten E. Christensen, Darren L. Poole, Timothy J. Donohoe
Publikováno v:
Organic Letters. 25:614-618
Autor:
Philip G. Humphreys, Niall A. Anderson, Paul Bamborough, Andrew Baxter, Chun-wa Chung, Rosa Cookson, Peter D. Craggs, Toryn Dalton, Julie C. L. Fournier, Laurie J. Gordon, Heather F. Gray, Matthew W. Gray, Richard Gregory, David J. Hirst, Craig Jamieson, Katherine L. Jones, Hripsimee Kessedjian, David Lugo, Grant McGonagle, Vipulkumar K. Patel, Christopher Patten, Darren L. Poole, Rab K. Prinjha, Cesar Ramirez-Molina, Inmaculada Rioja, Gail Seal, Kayleigh A. J. Stafford, Rishi R. Shah, Daniel Tape, Natalie H. Theodoulou, Laura Tomlinson, Sabri Ukuser, Ian D. Wall, Natalie Wellaway, Gemma White
Publikováno v:
Journal of Medicinal Chemistry. 65:15174-15207
The bromodomain and extra terminal (BET) family of proteins are an integral part of human epigenome regulation, the dysregulation of which is implicated in multiple oncology and inflammatory diseases. Disrupting the BET family bromodomain acetyl-lysi
Autor:
Cyrille Kiaku, Dorian Martinage, Yasemin Sicim, Matthew C. Leech, Jamie M. Walsh, Darren L. Poole, Joseph Mason, Iain C. A. Goodall, Perry Devo, Kevin Lam
Publikováno v:
Organic Letters.
Publikováno v:
Angewandte Chemie. 135
Publikováno v:
Lennox, A J J, Doobary, S & Poole, D L 2021, ' Intramolecular Alkene Fluoroarylation of Phenolic Ethers Enabled by Electrochemically Generated Iodane ', Journal of Organic Chemistry, vol. 86, no. 22, pp. 16095-16103 . https://doi.org/10.1021/acs.joc.1c01946
The 3-substituted chromane core is found in several bioactive natural products. Herein, we describe a route to 3-fluorinated chromanes from allylic phenol ethers. Our external oxidant-free approach takes advantage of an electro-chemical generation of
Autor:
Sylvain Charvet, Nessa Carson, Alfie G. Wills, Darren L. Poole, Claudio Battilocchio, Julien C. Vantourout, Scarborough Christopher Charles, Katherine Wheelhouse
Publikováno v:
Organic Process Research & Development. 25:2587-2600
Publikováno v:
Chemical Science
Through the use of model studies, an approach was conceived towards the synthesis of the taiwanschirin family of natural products. These are structurally complex compounds which represent highly challenging and biologically active targets for total s