Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Darren L. Poole"'
Autor:
Graeme W. Carlile, Qi Yang, Elizabeth Matthes, Jie Liao, Véronique Birault, Helen F. Sneddon, Darren L. Poole, Callum J. Hall, John W. Hanrahan, David Y. Thomas
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Most cases of cystic fibrosis (CF) are caused by class 2 mutations in the cystic fibrosis transmembrane regulator (CFTR). These proteins preserve some channel function but are retained in the endoplasmic reticulum (ER). Partial rescue of the
Externí odkaz:
https://doaj.org/article/6c974b2051ad451a915f788a93fa1833
Autor:
Matthew C. Leech, Dmitrii Nagornîi, Jamie M. Walsh, Cyrille Kiaku, Darren L. Poole, Joseph Mason, Iain C. A. Goodall, Perry Devo, Kevin Lam
Publikováno v:
Organic Letters. 25:1353-1358
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92587e0971d53356bdf859f4f6f7765e
https://doi.org/10.1021/acs.orglett.2c04305
https://doi.org/10.1021/acs.orglett.2c04305
Autor:
Cyrille Kiaku, Jamie M. Walsh, Matthew C. Leech, Darren L. Poole, Joseph Mason, Iain C. A. Goodall, Perry Devo, Kevin Lam
Publikováno v:
Organic Letters. 25:1147-1150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83a8d2639fba06cd72074997238f7cf3
https://doi.org/10.1021/acs.orglett.3c00128
https://doi.org/10.1021/acs.orglett.3c00128
Autor:
Aaron J. Day, Timothy C. Jenkins, Marvin Kischkewitz, Kirsten E. Christensen, Darren L. Poole, Timothy J. Donohoe
Publikováno v:
Organic Letters. 25:614-618
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5fba15712276cd32ea5c4065a4e89b5
https://doi.org/10.1021/acs.orglett.2c04149
https://doi.org/10.1021/acs.orglett.2c04149
Autor:
Philip G. Humphreys, Niall A. Anderson, Paul Bamborough, Andrew Baxter, Chun-wa Chung, Rosa Cookson, Peter D. Craggs, Toryn Dalton, Julie C. L. Fournier, Laurie J. Gordon, Heather F. Gray, Matthew W. Gray, Richard Gregory, David J. Hirst, Craig Jamieson, Katherine L. Jones, Hripsimee Kessedjian, David Lugo, Grant McGonagle, Vipulkumar K. Patel, Christopher Patten, Darren L. Poole, Rab K. Prinjha, Cesar Ramirez-Molina, Inmaculada Rioja, Gail Seal, Kayleigh A. J. Stafford, Rishi R. Shah, Daniel Tape, Natalie H. Theodoulou, Laura Tomlinson, Sabri Ukuser, Ian D. Wall, Natalie Wellaway, Gemma White
Publikováno v:
Journal of Medicinal Chemistry. 65:15174-15207
The bromodomain and extra terminal (BET) family of proteins are an integral part of human epigenome regulation, the dysregulation of which is implicated in multiple oncology and inflammatory diseases. Disrupting the BET family bromodomain acetyl-lysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247c403b556d0cdc2a89bb75345904c1
https://doi.org/10.1021/acs.jmedchem.2c01102
https://doi.org/10.1021/acs.jmedchem.2c01102
Autor:
Cyrille Kiaku, Dorian Martinage, Yasemin Sicim, Matthew C. Leech, Jamie M. Walsh, Darren L. Poole, Joseph Mason, Iain C. A. Goodall, Perry Devo, Kevin Lam
Publikováno v:
Organic Letters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e099978007c0b101b9118a9202931a1a
https://doi.org/10.1021/acs.orglett.3c00976
https://doi.org/10.1021/acs.orglett.3c00976
Publikováno v:
Angewandte Chemie. 135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbbea8f4705ed533a5af3fc0d1f25656
https://doi.org/10.1002/ange.202218195
https://doi.org/10.1002/ange.202218195
Publikováno v:
Lennox, A J J, Doobary, S & Poole, D L 2021, ' Intramolecular Alkene Fluoroarylation of Phenolic Ethers Enabled by Electrochemically Generated Iodane ', Journal of Organic Chemistry, vol. 86, no. 22, pp. 16095-16103 . https://doi.org/10.1021/acs.joc.1c01946
The 3-substituted chromane core is found in several bioactive natural products. Herein, we describe a route to 3-fluorinated chromanes from allylic phenol ethers. Our external oxidant-free approach takes advantage of an electro-chemical generation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b777a506629eac4f59537903692c368a
https://doi.org/10.1021/acs.joc.1c01946
https://doi.org/10.1021/acs.joc.1c01946
Autor:
Sylvain Charvet, Nessa Carson, Alfie G. Wills, Darren L. Poole, Claudio Battilocchio, Julien C. Vantourout, Scarborough Christopher Charles, Katherine Wheelhouse
Publikováno v:
Organic Process Research & Development. 25:2587-2600
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf5ab973b84664b1bd0417c618904b30
https://doi.org/10.1021/acs.oprd.1c00167
https://doi.org/10.1021/acs.oprd.1c00167
Publikováno v:
Chemical Science
Through the use of model studies, an approach was conceived towards the synthesis of the taiwanschirin family of natural products. These are structurally complex compounds which represent highly challenging and biologically active targets for total s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf297ce47c61560406a1d57ec200dc1b
https://doi.org/10.1039/d1sc04247e
https://doi.org/10.1039/d1sc04247e