Výsledky vyhledávání - "Darren L. Hughes"

Platelet integrin α2 I-domain specific antibodies produced via domain specific DNA vaccination combined with variable gene phage display

Autor: Samir W. Hamaia, Richard W. Farndale, Prachi Stafford, Anne Schoolmeester, Ian J. Harmer, Darren L. Hughes, Nicholas A. Watkins, Hans Deckmyn, Willem H. Ouwehand

Publikováno v: Thrombosis and Haemostasis. 94:1318-1326

SummaryAntibodies are a powerful tool for structure/function studies of platelet proteins. However, classic immunisation frequently elicits antibody responses against domains of minor functional interest. Robust strategies to generate antibodies agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f3cd8c4ffc74042036b1cdbb9c1ec5e
https://doi.org/10.1160/th05-06-0410

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The Natural History of Fetomaternal Alloimmunization to the Platelet-Specific Antigen HPA-1a (PlA1, Zwa) as Determined by Antenatal Screening

Autor: Shirley Jobson, Janet Rennie, Caroline Maciver, Christopher R. Palmer, Ruth M. Hadfield, Gerald Hackett, Willem H. Ouwehand, Lorna M. Williamson, Darren L. Hughes

Publikováno v: Europe PubMed Central

Immunization against the human platelet antigen (HPA)-1 alloantigen is the most common cause of severe fetal and neonatal thrombocytopenia. Fetal therapy has substantial risks and its indications need better definition. Of 24,417 consecutive pregnant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173ed60649c617dec284e06dfa74b468
https://doi.org/10.1182/blood.v92.7.2280

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Platelet integrin alpha2 I-domain specific antibodies produced via domain specific DNA vaccination combined with variable gene phage display

Autor: Darren L, Hughes, Prachi, Stafford, Samir W, Hamaia, lan J, Harmer, Anne, Schoolmeester, Hans, Deckmyn, Richard W, Farndale, Willem H, Ouwehand, Nicholas A, Watkins

Publikováno v: Thrombosis and haemostasis. 94(6)

Antibodies are a powerful tool for structure/function studies of platelet proteins. However, classic immunisation frequently elicits antibody responses against domains of minor functional interest. Robust strategies to generate antibodies against def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f049f8e6d721b890f52af2f82cc987ad
https://pubmed.ncbi.nlm.nih.gov/16411412

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Tracking and characterisation of transfused platelets by two colour, whole blood flow cytometry

Autor: Lorna M. Williamson, Darren L. Hughes, G. R. Evans, Paul Metcalfe, Alison H. Goodall

Publikováno v: British journal of haematology. 130(5)

We describe a flow cytometric technique to study transfused platelets in patients. By selecting donor/recipient pairs discrepant for HLA-A2, transfused platelets were identified using anti-HLA-A2 with a detection limit of5%, and accuracy within 4.3%

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2666ba8bd113a2a27a8ce9b969e776a
https://pubmed.ncbi.nlm.nih.gov/16115139

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