Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Darren L. Holmes"'
SITE-SPECIFIC LABELING OF A PROTEIN LYSINE RESIDUE BY NOVEL KINETIC LABELING COMBINATORIAL LIBRARIES
Autor:
Allen Krantz, Arthur M Hanel, Ivona Strug, Andrzej Wilczynski, Jeremy J Wolff, Wolin Huang, Linda H Huang, Tina Settineri, Darren L Holmes, Margaret C Hardy, Dominique P Bridon
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 9, Iss 15 (2014)
The first example of a kinetic labeling library designed to enable the discovery of affinity labels is presented. Each library component (1) consists of a variable peptidyl component linked to a biotinyl moiety by a 4-mercaptobenzoyl linker in thioes
Externí odkaz:
https://doaj.org/article/b5781b56027b45358e4cbb98b9eca02e
Publikováno v:
Journal of the American Chemical Society. 119:7665-7669
This paper describes the solid-phase syntheses of artificial β-sheets 1−4, which mimic the structure and hydrogen-bonding patterns of protein β-sheets. In these compounds, molecular templates induce β-sheet structures in attached peptide strands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2458e1522c205988b2a82d2872c96769
https://doi.org/10.1021/ja9710971
https://doi.org/10.1021/ja9710971
Publikováno v:
Journal of the American Chemical Society. 119:5413-5424
This paper reports the development of β-strand mimic B, which duplicates the hydrogen-bonding functionality of one edge of a tetrapeptide β-strand. When attached to a tripeptide by a suitable linking group, β-strand mimic B forms a hydrogen-bonded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f53d9efe10dcd81b10be3b6057f8fda6
https://doi.org/10.1021/ja963843s
https://doi.org/10.1021/ja963843s
Publikováno v:
Experientia. 52:639-642
High-field 13C-NMR of 13C-enriched compounds in dilute aqueous d6-Me2-SO solutions provides a simple, accurate method for measuring pK(a)s of sparingly soluble carboxylic acids. Using this method, we found the pK(a)s of mesobilirubin-XIII alpha to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e2b7a5f8f1c9fd3c291e743d5479e1
https://doi.org/10.1007/bf01969747
https://doi.org/10.1007/bf01969747
Autor:
Darren L. Holmes, David A. Lightner
Publikováno v:
Tetrahedron. 52:5319-5338
Simple dicarboxylic acids: adipic ( 1 ), succinic ( 2 ) and malonic ( 3 ); more complex linear tetrapyrroles with two propionic acid groups: mesobiliverdin-XIIIα ( 4 ) and mesobilirubin-XIIIα ( 5 ), and a rubin analog with a gem -dimethyl at C 10 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad09a19261570941750ea98b8e025527
https://doi.org/10.1016/0040-4020(96)00153-6
https://doi.org/10.1016/0040-4020(96)00153-6
Publikováno v:
Journal of Biological Chemistry. 271:2397-2405
Biliverdin and bilirubin are naturally-occurring tetrapyrrolic bile pigments containing two propionic acid side chains. These side chains, and their propensity for ionization, are critical in the biological disposition of the pigments. Surprisingly,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5603cab41e05c3b5a46db2b5580ce54
https://doi.org/10.1074/jbc.271.5.2397
https://doi.org/10.1074/jbc.271.5.2397
Publikováno v:
Tetrahedron. 51:10663-10678
A sterically congested analog of bilirubin with propionic acid groups replaced by pivalic acids (1) was synthesized from methyl 3-(2,4-dimethyl-5-ethoxycarbonyl-l H -pyrrol-3-yl)-2-methylpropionate ( 8 ). UV-visible and NMR spectroscopic analyses of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f80da2a641339d2112e07b3a63ed0b50
https://doi.org/10.1016/0040-4020(95)00658-u
https://doi.org/10.1016/0040-4020(95)00658-u
Autor:
Darren L. Holmes, David A. Lightner
Publikováno v:
Tetrahedron. 51:1607-1622
Six monocarboxylic acids were prepared highly enriched with 13C in their CO2H groups, and their pKa values were determined at low concentrations 10−4−10−5 M in H2O and in H2O-(CD3)2SO mixtures by analysis of pH-dependent 13CO2H NMR chemical shi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5dc416ca917445482b7c5cee18593ed
https://doi.org/10.1016/0040-4020(94)01052-2
https://doi.org/10.1016/0040-4020(94)01052-2
Autor:
David A. Lightner, Darren L. Holmes
Publikováno v:
Journal of Heterocyclic Chemistry. 32:113-121
Unsymmetric bile pigment analogs of mesobilirubin-XIIIα and mesobilirubin-IVα were synthesized following oxidative coupling of dipyrrinones: methyl xanthobilirubinate with kryptopyrromethenone; methyl ψ-xanthobilirubinate with kryptopyrromethenone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3d1371ba1dd4d0ec840cb60224db404
https://doi.org/10.1002/jhet.5570320120
https://doi.org/10.1002/jhet.5570320120
Autor:
Darren L. Holmes, Sharad Magar, Eckard Weber, John F. W. Keana, Graham J. Durant, Kyle R. Gee, Scott T. Wong
Publikováno v:
Bioconjugate Chemistry. 4:226-229
A novel radiolabeled photoaffinity ligand has been synthesized for the phencyclidine (PCP) site of the N-methyl-D-aspartate (NMDA) receptor. N-(3-Azidophenyl)-N-methyl-N'-([4-3H]-1-naphthyl)guanidine (13) was prepared with a specific activity of 25 C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59881ec51d0e2c906fbeacc211eb79bd
https://doi.org/10.1021/bc00021a007
https://doi.org/10.1021/bc00021a007