Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Darren L. Brown"'
Autor:
Marija Kojic, Monika Gaik, Bence Kiska, Anna Salerno-Kochan, Sarah Hunt, Angelo Tedoldi, Sergey Mureev, Alun Jones, Belinda Whittle, Laura A. Genovesi, Christelle Adolphe, Darren L. Brown, Jennifer L. Stow, Kirill Alexandrov, Pankaj Sah, Sebastian Glatt, Brandon J. Wainwright
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Elp6 is a component of the Elongator complex that regulates tRNAs and translation. Here the authors identify a mutation in the Elp6 gene that contributes to the cerebellar ataxia-like phenotype in a mutant mouse.
Externí odkaz:
https://doaj.org/article/abbd7a3dce6a4cee904088b04300ff36
Autor:
Mercedes Monteleone, Amanda C. Stanley, Kaiwen W. Chen, Darren L. Brown, Jelena S. Bezbradica, Jessica B. von Pein, Caroline L. Holley, Dave Boucher, Melanie R. Shakespear, Ronan Kapetanovic, Verena Rolfes, Matthew J. Sweet, Jennifer L. Stow, Kate Schroder
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1425-1433 (2018)
Summary: IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1-dependent GSDMD cleavage, which also induces pyroptosis. Mechanisms
Externí odkaz:
https://doaj.org/article/a43be258b327448fa6e72d48bc208d26
Autor:
Graham S Cooke, Adeeba Kamarulzaman, Margaret Hellard, Jürgen K. Rockstroh, Kenneth H. Mayer, Georg M. N. Behrens, Denise Naniche, Nikos Dedes, Ricardo Baptista Leite, Jeffrey V. Lazarus, David Serwadda, Sanjay Bhagani, María José Fuster-Ruiz de Apodaca, Laura Waters, Shabbar Jaffar, Carlos F. Caceres, Diana Romero, Peter Reiss, Richard Elliott, Susan Buchbinder, Pedro Cahn, Richard Harding, Julia del Amo, Reena Rajasuriar, Teymur Noori, Kelly Safreed-Harmon, Antonella d'Arminio Monforte, Timothy B. Hallett, Jane Anderson, Wafaa El-Sadr, Darren L. Brown, Marina B. Klein, Doreen Moraa, Sharon R Lewin, Nesrine Rizk, Denis Nash, Giovanni Guaraldi, Graham Brown, Anton Pozniak, Georgina Caswell, Caroline A. Sabin, Linda-Gail Bekker, Patrizia Carrieri, Meaghan Kall, José Antonio Pérez-Molina
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4450. ⟨10.1038/s41467-021-24673-w⟩
Nature Communications, 2021, 12 (1), pp.4450. ⟨10.1038/s41467-021-24673-w⟩
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4450. ⟨10.1038/s41467-021-24673-w⟩
Nature Communications, 2021, 12 (1), pp.4450. ⟨10.1038/s41467-021-24673-w⟩
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Health systems have improved their abilities to identify, diagnose, treat and, increasingly, achieve viral suppression among people living with HIV (PLHIV). Despite these advances, a higher burden of multimorbidity and poorer health-related quality o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f1d6e0f7ca5ff6709b5e14b4cbdc6b
https://doi.org/10.1038/s41467-021-24673-w
https://doi.org/10.1038/s41467-021-24673-w
Autor:
Zhijian Xiao, Neeraj Tuladhar, Yvette W. H. Koh, Jennifer L. Stow, Darren L. Brown, Nicholas D. Condon, Yu Hung
Publikováno v:
Journal of visualized experiments : JoVE. (174)
Macropinocytosis is a highly conserved but still incompletely understood process that is essential for the uptake and ingestion of fluid, fluid-phase nutrients and other material in cells. The dramatic extension of cell surface ruffles, their closure
Autor:
Mark L. Watson, Darren L. Brown, Alexander B. Stilgoe, Jennifer L. Stow, Halina Rubinsztein-Dunlop
Publikováno v:
Optica. 9:1066
Studying the mechanical properties of living cells provides opportunities to unravel the physical phenomena that govern biological functions. Macropinocytosis is a cellular pathway that involves the non-selective uptake of extracellular fluid through
Autor:
Fabian B. H. Rehm, Jennifer L. Stow, Thomas Durek, Sina Jami, Mathilde R. Israel, Samuel D. Robinson, Edward K. Gilding, Jennifer R. Deuis, Irina Vetter, Peta J. Harvey, Brett Hamilton, David J. Craik, Darren L. Brown, Aaron G. Poth, Kuok Yap, David Andersson
Publikováno v:
Science Advances
Gilding, E K, Jami, S, Duis, J R, Israel, M R, Harvey, P J, Poth, A G, Rehm, F B H, Stow, J L, Robinson, S D, Yap, K, Brown, D L, Hamilton, B R, Andersson, D, Craik, D J, Vetter, I & Durek, T 2020, ' Neurotoxic Peptides from the Venom of the Giant Australian Stinging Tree ', Science Advances, vol. 6, no. 38, eabb8828, pp. 1-9 . https://doi.org/10.1126/sciadv.abb8828
Gilding, E K, Jami, S, Duis, J R, Israel, M R, Harvey, P J, Poth, A G, Rehm, F B H, Stow, J L, Robinson, S D, Yap, K, Brown, D L, Hamilton, B R, Andersson, D, Craik, D J, Vetter, I & Durek, T 2020, ' Neurotoxic Peptides from the Venom of the Giant Australian Stinging Tree ', Science Advances, vol. 6, no. 38, eabb8828, pp. 1-9 . https://doi.org/10.1126/sciadv.abb8828
The pain-inducing components of Australian stinging tree venom are miniproteins that modulate voltage-gated sodium channels.
Stinging trees from Australasia produce remarkably persistent and painful stings upon contact of their stiff epidermal h
Stinging trees from Australasia produce remarkably persistent and painful stings upon contact of their stiff epidermal h
Autor:
Anna Salerno-Kochan, Bence Kiska, Kirill Alexandrov, Belinda Whittle, Christelle Adolphe, Marija Kojic, Sergey Mureev, Alun Jones, Laura A. Genovesi, Sarah Hunt, Angelo Tedoldi, Pankaj Sah, Monika Gaik, Brandon J. Wainwright, Darren L. Brown, Sebastian Glatt, Jennifer L. Stow
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
Cerebellar ataxias are severe neurodegenerative disorders with an early onset and progressive and inexorable course of the disease. Here, we report a single point mutation in the gene encoding Elongator complex subunit 6 causing Purkinje neuron degen
Autor:
Ronan Kapetanovic, Darren L. Brown, Matthew J. Sweet, Dave Boucher, Caroline L. Holley, Jelena S. Bezbradica, Jennifer L. Stow, Kate Schroder, Kaiwen W. Chen, Verena Rolfes, Amanda C. Stanley, Mercedes Monteleone, Jessica B. von Pein, Melanie R. Shakespear
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1425-1433 (2018)
Cell Reports, vol. 24, no. 6, pp. 1425-1433
Cell Reports, vol. 24, no. 6, pp. 1425-1433
Summary: IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1-dependent GSDMD cleavage, which also induces pyroptosis. Mechanisms
Autor:
Danae M. Sharp, Diego Chacon, Michelle van Geldermalsen, James S. Wilmott, Dominik Beck, Jeff Holst, Graham J. Mann, Jennifer L. Stow, Goldie Y. L. Lui, Camelia Quek, Darren L. Brown, Rain Y Q Kwan, John F. Thompson, Louise Jackett, Kimberley A. Beaumont, Wolfgang Weninger, Nikolas K. Haass, Shweta Tikoo, Dajiang Guo, Richard A. Scolyer, Jason W. H. Wong, Siew Li Lai
© 2018 UICC Despite recent advances in targeted and immune-based therapies, advanced stage melanoma remains a clinical challenge with a poor prognosis. Understanding the genes and cellular processes that drive progression and metastasis is critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ed3f6fdf192c349deb76f52f73c04d
https://hdl.handle.net/10453/132569
https://hdl.handle.net/10453/132569
Autor:
Pavel Dolezal, Marketa Petru, Andrea Bugarcic, Ralf Schuelein, Patrice Newton, Jennifer L. Stow, Amanda C. Stanley, Rachael Z. Murray, Lin Luo, Brett M. Collins, Elizabeth L. Hartland, Darren L. Brown, Nathan P. King, Vojtech Zarsky, Rohan D. Teasdale
Publikováno v:
Cellular Microbiology. 17:767-784
Upon infection, Legionella pneumophila uses the Dot/Icm type IV secretion system to translocate effector proteins from the Legionella-containing vacuole (LCV) into the host cell cytoplasm. The effectors target a wide array of host cellular processes