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Contents: Supplementary Methods Quantification of cetuximab by ELISA Fluorescent nanoparticles as probes of tumor permeability Pharmacokinetic modeling of cetuximab plasma concentrations Supplementary Tables Table S1. Mutation profiles of PDAC PDX mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410318a82ecbd7a58a4bf6d80c78e62a
https://doi.org/10.1158/1535-7163.22506447
https://doi.org/10.1158/1535-7163.22506447
Despite frequent overexpression of numerous growth factor receptors by pancreatic ductal adenocarcinomas (PDAC), such as EGFR, therapeutic antibodies have not proven effective. Desmoplasia, hypovascularity, and hypoperfusion create a functional drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3653993317b88a1d51ad64e6181b35a
https://doi.org/10.1158/1535-7163.c.6538401.v1
https://doi.org/10.1158/1535-7163.c.6538401.v1
Autor:
Ninfa L. Straubinger, Stephen Caddick, Daniel B. Longley, James F Burrows, Darren K.W. Chan, Charlene Minx, Michelle K. Greene, Jun Wang, Robert M. Straubinger, Sandra Van Schaeybroeck, James R. Baker, Vijay Chudasama, Eifion Robinson, Ting Chen, Christopher J. Scott, Donald E. Mager
Publikováno v:
Greene, M K, Chen, T, Robinson, E, Straubinger, N L, Minx, C, Chan, D K W, Wang, J, Burrows, J F, Van Schaeybroeck, S, Baker, J R, Caddick, S, Longley, D B, Mager, D E, Straubinger, R M, Chudasama, V & Scott, C J 2020, ' Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer ', British Journal of Cancer . https://doi.org/10.1038/s41416-020-01046-6
British Journal of Cancer
British Journal of Cancer
Background Antibody-drug conjugate (ADC) construction poses numerous challenges that limit clinical progress. In particular, common bioconjugation methods afford minimal control over the site of drug coupling to antibodies. Here, such difficulties ar
Autor:
Martin Clynes, Michael C. Johnston, Katie Stott, William J. McDaid, Julie A. Nicoll, Michelle K. Greene, Robert M. Straubinger, Darren K.W. Chan, Daniel B. Longley, Christopher J. Scott, Sandra Roche, Ninfa L. Straubinger, Jennifer Fox, Kelly M. Redmond, Nyree Crawford, Peter Smyth
Publikováno v:
J Control Release
Johnston, M, Nicoll, J, Redmond, K, Smyth, P, Greene, M, McDaid, W, Crawford, N, Stott, K, Fox, J, Longley, D & Scott, C 2020, ' DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models ', Journal of Controlled Release, vol. 324, pp. 610-619 . https://doi.org/10.1016/j.jconrel.2020.05.046
Johnston, M, Nicoll, J, Redmond, K, Smyth, P, Greene, M, McDaid, W, Crawford, N, Stott, K, Fox, J, Longley, D & Scott, C 2020, ' DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models ', Journal of Controlled Release, vol. 324, pp. 610-619 . https://doi.org/10.1016/j.jconrel.2020.05.046
Pancreatic cancer is usually advanced and drug resistant at diagnosis. A potential therapeutic approach outlined here uses nanoparticle (NP)-based drug carriers, which have unique properties that enhance intra-tumor drug exposure and reduce systemic
Publikováno v:
Mol Cancer Ther
Despite frequent overexpression of numerous growth factor receptors by pancreatic ductal adenocarcinomas (PDAC), such as EGFR, therapeutic antibodies have not proven effective. Desmoplasia, hypovascularity, and hypoperfusion create a functional drug
Autor:
Johann R. N. Cooke, Darren K.W. Chan, Jason A. Ellis, Shailendra Joshi, Irving J. Bigio, Jeffrey N. Bruce, Shaolie S. Hossain, Rajinder P. Singh-Moon, Robert M. Straubinger, Mei Wang
Publikováno v:
Drug Delivery and Translational Research. 6:225-233
Nanoparticles such as liposomes may be used as drug delivery vehicles for brain tumor therapy. Particle geometry and electrostatic properties have been hypothesized to be important determinants of effective tumor targeting after intraarterial injecti