Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Darren J. Perkins"'
Autor:
Alexandra M. Vlk, Daniel Prantner, Kari Ann Shirey, Darren J. Perkins, Marguerite S. Buzza, Vivek Thumbigere-Math, Achsah D. Keegan, Stefanie N. Vogel
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Toll-like receptor 4 (TLR4) is an innate immune receptor responsive to lipopolysaccharide (LPS). Single nucleotide polymorphisms (SNPs) in human TLR4 that encode an A896G transition at SNP rs4986790 (D299G) and a C1196T transition at SNP rs4
Externí odkaz:
https://doaj.org/article/f82f77beb83c4333bc1d7309aed50634
Autor:
Kari Ann Shirey, Darren J. Perkins, Wendy Lai, Wei Zhang, Lurds R. Fernando, Fabian Gusovsky, Jorge C. G. Blanco, Stefanie N. Vogel
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT We previously reported that the Toll-like receptor 4 (TLR4) antagonist Eritoran blocks acute lung injury (ALI) therapeutically in mouse and cotton rat models of influenza. However, secondary (2°) bacterial infection following influenza viru
Externí odkaz:
https://doaj.org/article/d53eb0ce4dd8466f9c6dd00fde7aaa19
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2017 (2021)
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial joints. Inflammation, new blood vessel formation (angiogenesis) and bone resorption (osteoclastogenesis) are three key processes involved in the
Externí odkaz:
https://doaj.org/article/0fc9a3326b6841ae817e382c339d4b31
Publikováno v:
mBio, Vol 1, Iss 5 (2010)
ABSTRACT Overwhelming inflammation triggered by systemic infection in bacterial sepsis contributes to the pathology of this condition. Toll-like receptors (TLRs) are important in early septic inflammation. As a safeguard, the innate immune system has
Externí odkaz:
https://doaj.org/article/3002e52d2b2a4ad39177bec130c18d05
Autor:
W.Y.C. Lai, Shreeram C. Nallar, Darren J. Perkins, Stefanie N. Vogel, Katharina Richard, Anne Marie Hansen, Beverly H. Koller
Publikováno v:
Nature immunology
The unique cell biology of Toll-like receptor 4 (TLR4) allows it to initiate two signal-transduction cascades: a signal dependent on the adaptors TIRAP (Mal) and MyD88 that begins at the cell surface and regulates proinflammatory cytokines, and a sig
Publikováno v:
Innate Immunity, Vol 27 (2021)
Innate Immunity
Innate Immunity
The capacity for macrophages to polarize into distinct functional activation states (e.g., M1, M2) is critical to tune an inflammatory response to the relevant infection or injury. Alternative or M2 polarization of macrophages is most often achieved
Autor:
Rachel Fanaroff, Alexandra Vlk, Kari Ann Shirey, W.Y.C. Lai, Darren J. Perkins, Chiguang Feng, Shreeram C. Nallar, Stefanie N. Vogel, Vladimir Y. Toshchakov, Andrei E. Medvedev, Kurt H. Piepenbrink, Katharina Richard, Daniel Prantner, Jorge C. G. Blanco, Archana Gopalakrishnan
Publikováno v:
The Journal of Experimental Medicine
We developed mice expressing Tlr4 SNPs homologous to those expressed in humans and associated with infectious and inflammatory diseases. Cellular and molecular analyses of TLR4 signaling in wild-type vs. TLR4-SNP mice revealed novel mechanisms of LPS
Autor:
Yang Song, Robert K. Ernst, Stefanie N. Vogel, W.Y.C. Lai, Darren J. Perkins, Shreeram C. Nallar, Lynn D. Hawkins, Kari Ann Shirey, Erin Harberts, Anup Mahurkar, Katharina Richard, Archana Gopalakrishnan, Alexandra Vlk
Publikováno v:
Vaccine
Toll-like receptors (TLRs), a family of "pattern recognition receptors," bind microbial and host-derived molecules, leading to intracellular signaling and proinflammatory gene expression. TLR4 is unique in that ligand-mediated activation requires the
Publikováno v:
Bio-protocol. 9(18)
Internalization of cell surface Toll Like Receptor 4 (TLR4) is a convenient read-out to measure LPS dependent activation of the TRIF adaptor pathway. We here provide a protocol to quantify the LPS dependent internalization of TLR4 using thioglycollat
Autor:
Darren J. Perkins, Edwin H. Kriel, Myron M. Levine, Louis J. DeTolla, Michael M. Lipsky, Steven T. Shipley, Aruna Panda, Marcela F. Pasetti, Marcelo B. Sztein, Girish Ramachandran, Ellen E. Higginson, Sharon M. Tennant, Rosangela Salerno-Goncalves
Publikováno v:
Infection and Immunity. 86
A notable proportion of Salmonella-associated gastroenteritis in the United States is attributed to Salmonella enterica serovar Typhimurium. We have previously shown that live-attenuated S. Typhimurium vaccine candidate CVD 1921 (I77 ΔguaBA ΔclpP)