Zobrazeno 1 - 10 of 56 pro vyhledávání: '"Darren J. Newton"'
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Akademický článek
The prothrombotic state in paroxysmal nocturnal hemoglobinuria: a multifaceted source
Autor: Barnaby Peacock-Young, Fraser L. Macrae, Darren J. Newton, Anita Hill, Robert A S Ariëns
Publikováno v: Haematologica, Vol 103, Iss 1 (2018)
Paroxysmal nocturnal hemoglobinuria is a rare acquired hematologic disorder, the most serious complication of which is thrombosis. The increased incidence of thrombosis in paroxysmal nocturnal hemoglobinuria is still poorly understood, but unlike man
Externí odkaz: https://doaj.org/article/8f7334ac748f47f4a461ccad83d669cb
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2
Immunophenotypic assessment of PNH clones in major and minor cell lineages in the peripheral blood of patients with paroxysmal nocturnal hemoglobinuria
Autor: Stephen J. Richards, Anita J. Dickinson, Darren J. Newton, Peter Hillmen
Publikováno v: Cytometry Part B: Clinical Cytometry. 102:487-497
Flow cytometric immunophenotyping is essential for the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH). Most cases have easy to interpret flow cytometry profiles with red cells, neutrophils and monocytes showing complete deficiency of glycopho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e5594b01f9b836bdd34a31febef193
https://doi.org/10.1002/cyto.b.22094
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7
Patients with paroxysmal nocturnal hemoglobinuria demonstrate a prothrombotic clotting phenotype which is improved by complement inhibition with eculizumab
Autor: Fraser L. Macrae, Claire E McKinley, Emma Linton, Polly Bowman, Anita Hill, Sam Quested, Stephen R. Baker, Robert A. S. Ariëns, Barnaby Peacock-Young, Darren J. Newton, Talha Munir, Peter Hillmen, Morag Griffin, Daniel Payne, Deborah Clarke
Publikováno v: American Journal of Hematology. 95:944-952
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder, characterized by complement-mediated intravascular hemolysis and thrombosis. The increased incidence of PNH-driven thrombosis is still poorly understood, but unlike other thr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3e51d1f5bbeb8236f1006ba103c3a2
https://doi.org/10.1002/ajh.25841
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8
Tofacitinib Blocks Entheseal Lymphocyte Activation and modulates MSC adipogenesis but does not directly affect chondro- and osteogenesis
Autor: Abdulla Watad, Elena Jones, Darren J. Newton, Hannah Rowe, Dennis McGonagle, Charlie Bridgewood, Richard Cuthbert, Tobias Russell
Publikováno v: Immuno; Volume 1; Issue 4; Pages: 545-557
Immuno, Vol 1, Iss 38, Pp 545-557 (2021)
Entheseal spinal inflammation and new bone formation with progressive ankylosis may occur in ankylosing spondylitis (AS) and psoriatic arthritis (PsA). This study evaluated whether JAK inhibition with tofacitinib modulated the key disease associated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1c258046bd6d2ad4763af2f9c7e262
https://doi.org/10.20944/preprints202107.0494.v2
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9
Exploratory Study of MYD 88 L265P, Rare NLRP 3 Variants, and Clonal Hematopoiesis Prevalence in Patients With Schnitzler Syndrome
Autor: Catherine Cargo, Helen J. Lachmann, Karoline Krause, Shelly Pathak, Gina M. Doody, Jan Taylor, Philip N. Hawkins, Sinisa Savic, Darren J. Newton, Dorota Rowczenio, Roger G. Owen, Claire Taylor
Publikováno v: Arthritis & Rheumatology. 71:2121-2125
Objective To assess the prevalence of the MYD88 L265P mutation and variants within NLRP3 and evaluate the status of oligoclonal hematopoiesis in 30 patients with Schnitzler syndrome (SchS). Methods Thirty patients with SchS were recruited from 3 clin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4221f652a88750fb9bdaa679bf77314e
https://doi.org/10.1002/art.41030
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10
Unexpected connections of the IL-23/IL-17 and IL-4/IL-13 cytokine axes in inflammatory arthritis and enthesitis
Autor: Nicola Bragazzi, Darren J. Newton, Miriam Wittmann, Dennis McGonagle, Charlie Bridgewood
Publikováno v: Seminars in immunology. 58
The IL-23/IL-17 cytokine axis is related to spondyloarthropathy (SpA) pattern diseases that target the skin, eye, gut and joints. These share overlapping target tissues with Th2 type or allergic diseases, including the skin, eye and gut but SpA disea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d2302f42db3b1b19e4e7077e017b3c
https://pubmed.ncbi.nlm.nih.gov/34799224
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