Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Darren J. Cole"'
Autor:
Emmanuel T. Osei, Irene H. Heijink, Xian Li, Darren J. Cole, Corry-Anke Brandsma, Chen Xi Yang, Tillie-Louise Hackett, Leila B. Mostaço-Guidolin, Vicky Li, May Fouadi, Soheil M. Hajimohammadi, Geoffrey N. Maksym, David C. Walker, Fanny Chu, Furquan Shaheen, Jari Ullah
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, 200(4), 431-443. AMER THORACIC SOC
American Journal of Respiratory and Critical Care Medicine, 200(4), 431-443. AMER THORACIC SOC
RATIONALE: Histological stains have been used as the gold standard to visualize extracellular matrix (ECM) changes associated with airway remodeling in asthma, yet they provide no information on the biochemical and structural characteristics of the E
Autor:
Mary Wang, Darren J. Cole, Teal S Hallstrand, Tillie-Louise Hackett, Leila B. Mostaço-Guidolin, Emmanuel T. Osei, Wim Timens, Aileen Hsieh, Stephanie M. Warner, May Al-Fouadi, Geoffrey N. Maksym, Corry-Anke Brandsma, Irene H. Heijink
Publikováno v:
Scientific Reports, 10(1):8721. Nature Publishing Group
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
In asthma, the airway epithelium has an impaired capacity to differentiate and plays a key role in the development of airway inflammation and remodeling through mediator release. The study objective was to investigate the release of (IL)-1 family mem
Autor:
Darren J. Cole, Sarah C. Connolly, Carolyn A. Lall, Paul G. Smith, Nigel J. Fairbank, James D. MacKinnon, Geoffrey N. Maksym
Publikováno v:
Journal of Applied Physiology. 111:955-963
A deep inspiration (DI) temporarily relaxes agonist-constricted airways in normal subjects, but in asthma airways are refractory and may rapidly renarrow, possibly due to changes in the structure and function of airway smooth muscle (ASM). Chronic la
Development and characterization of a 3D multicell microtissue culture model of airway smooth muscle
Autor:
Elizabeth A. Cowley, Darren J. Cole, Geoffrey N. Maksym, Thomas Boudou, Adrian R. West, Wesley R. Legant, Matthew J. Walker, John T. Favreau, Christopher S. Chen, Glenn R. Gaudette, Nishat Zaman
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2013, 304 (1), pp.L4-L16. ⟨10.1152/ajplung.00168.2012⟩
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2013, 304 (1), pp.L4-L16. ⟨10.1152/ajplung.00168.2012⟩
International audience; Airway smooth muscle (ASM) cellular and molecular biology is typically studied with single-cell cultures grown on flat 2D substrates. However, cells in vivo exist as part of complex 3D structures, and it is well established in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74b9713b8b3f43cbd5ce27dd62adaa6
https://hal.archives-ouvertes.fr/hal-01545311
https://hal.archives-ouvertes.fr/hal-01545311
Publikováno v:
A98. BREAKING DOWN THE WALL: NOVEL INSIGHTS IN AIRWAY WALL REMODELING.
Publikováno v:
D98. SMOOTH MUSCLE CONTRACTION REVEALS ITS SECRETS.
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 99(2)
The application of mechanical stresses to the airway smooth muscle (ASM) cell causes time-dependent cytoskeletal stiffening and remodeling (Deng L, Fairbank NJ, Fabry B, Smith PG, and Maksym GN. Am J Physiol Cell Physiol 287: C440–C448, 2004). We i