Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Darren J Perkins"'
Publikováno v:
Innate Immunity, Vol 27 (2021)
The capacity for macrophages to polarize into distinct functional activation states (e.g., M1, M2) is critical to tune an inflammatory response to the relevant infection or injury. Alternative or M2 polarization of macrophages is most often achieved
Externí odkaz:
https://doaj.org/article/78e8deb5406243df8789a2c190d4578b
Autor:
Xiaowei Wang, Dana K Shaw, Holly L Hammond, Fayyaz S Sutterwala, Manira Rayamajhi, Kari Ann Shirey, Darren J Perkins, Joseph V Bonventre, Thangam S Velayutham, Sean M Evans, Kyle G Rodino, Lauren VieBrock, Karen M Scanlon, Nicholas H Carbonetti, Jason A Carlyon, Edward A Miao, Jere W McBride, Michail Kotsyfakis, Joao H F Pedra
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005803 (2016)
Rickettsial agents are sensed by pattern recognition receptors but lack pathogen-associated molecular patterns commonly observed in facultative intracellular bacteria. Due to these molecular features, the order Rickettsiales can be used to uncover br
Externí odkaz:
https://doaj.org/article/130f8b62410e47cdafb35a596bcc86c1
Autor:
Girish Ramachandran, Darren J Perkins, Patrick J Schmidlein, Mohan E Tulapurkar, Sharon M Tennant
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 1, p e3394 (2015)
Invasive non-typhoidal Salmonella (iNTS) are an important cause of septicemia in children under the age of five years in sub-Saharan Africa. A novel genotype of Salmonella enterica subsp. enterica serovar Typhimurium (multi-locus sequence type [ST] 3
Externí odkaz:
https://doaj.org/article/8723445071544897bd21a048d8f0665a
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003479 (2013)
The cell surface/endosomal Toll-like Receptors (TLRs) are instrumental in initiating immune responses to both bacteria and viruses. With the exception of TLR2, all TLRs and cytosolic RIG-I-like receptors (RLRs) with known virus-derived ligands induce
Externí odkaz:
https://doaj.org/article/624752742ea14c8f843af5a374f78d6d
Autor:
Alexandra M. Vlk, Daniel Prantner, Kari Ann Shirey, Darren J. Perkins, Marguerite S. Buzza, Vivek Thumbigere-Math, Achsah D. Keegan, Stefanie N. Vogel
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Toll-like receptor 4 (TLR4) is an innate immune receptor responsive to lipopolysaccharide (LPS). Single nucleotide polymorphisms (SNPs) in human TLR4 that encode an A896G transition at SNP rs4986790 (D299G) and a C1196T transition at SNP rs4
Externí odkaz:
https://doaj.org/article/f82f77beb83c4333bc1d7309aed50634
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 4
International Journal of Molecular Sciences, Vol 22, Iss 2017, p 2017 (2021)
Volume 22
Issue 4
International Journal of Molecular Sciences, Vol 22, Iss 2017, p 2017 (2021)
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial joints. Inflammation, new blood vessel formation (angiogenesis) and bone resorption (osteoclastogenesis) are three key processes involved in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f00f99e55044168d563b2146f72a6b
http://europepmc.org/articles/PMC7922345
http://europepmc.org/articles/PMC7922345
Publikováno v:
Innate Immunity, Vol 27 (2021)
Innate Immunity
Innate Immunity
The capacity for macrophages to polarize into distinct functional activation states (e.g., M1, M2) is critical to tune an inflammatory response to the relevant infection or injury. Alternative or M2 polarization of macrophages is most often achieved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e777374e9b061f6954558315a9059c4
https://doaj.org/article/78e8deb5406243df8789a2c190d4578b
https://doaj.org/article/78e8deb5406243df8789a2c190d4578b
Autor:
Rachel Fanaroff, Alexandra Vlk, Kari Ann Shirey, W.Y.C. Lai, Darren J. Perkins, Chiguang Feng, Shreeram C. Nallar, Stefanie N. Vogel, Vladimir Y. Toshchakov, Andrei E. Medvedev, Kurt H. Piepenbrink, Katharina Richard, Daniel Prantner, Jorge C. G. Blanco, Archana Gopalakrishnan
Publikováno v:
The Journal of Experimental Medicine
We developed mice expressing Tlr4 SNPs homologous to those expressed in humans and associated with infectious and inflammatory diseases. Cellular and molecular analyses of TLR4 signaling in wild-type vs. TLR4-SNP mice revealed novel mechanisms of LPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d80baa4496263fd37a504de4a831ded
https://doi.org/10.1084/jem.20200675
https://doi.org/10.1084/jem.20200675
Autor:
W.Y.C. Lai, Shreeram C. Nallar, Darren J. Perkins, Stefanie N. Vogel, Katharina Richard, Anne Marie Hansen, Beverly H. Koller
Publikováno v:
Nature immunology
The unique cell biology of Toll-like receptor 4 (TLR4) allows it to initiate two signal-transduction cascades: a signal dependent on the adaptors TIRAP (Mal) and MyD88 that begins at the cell surface and regulates proinflammatory cytokines, and a sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836d8e838165ece258d795118347fc91
http://europepmc.org/articles/PMC6240378
http://europepmc.org/articles/PMC6240378
Autor:
Yang Song, Robert K. Ernst, Stefanie N. Vogel, W.Y.C. Lai, Darren J. Perkins, Shreeram C. Nallar, Lynn D. Hawkins, Kari Ann Shirey, Erin Harberts, Anup Mahurkar, Katharina Richard, Archana Gopalakrishnan, Alexandra Vlk
Publikováno v:
Vaccine
Toll-like receptors (TLRs), a family of "pattern recognition receptors," bind microbial and host-derived molecules, leading to intracellular signaling and proinflammatory gene expression. TLR4 is unique in that ligand-mediated activation requires the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a000d67496b0791240c40f28efbb53d4
https://pubmed.ncbi.nlm.nih.gov/32389496
https://pubmed.ncbi.nlm.nih.gov/32389496