Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Darren J Mushrush"'
Publikováno v:
PLoS Pathogens, Vol 4, Iss 12, p e1000245 (2008)
Clostridium botulinum neurotoxin (BoNT) causes flaccid paralysis by disabling synaptic exocytosis. Intoxication requires the tri-modular protein to undergo conformational changes in response to pH and redox gradients across endosomes, leading to the
Externí odkaz:
https://doaj.org/article/dc8dbb1632d54f40a314df57e8c39fe0
Autor:
Rory N. Pruitt, D. Borden Lacy, Darren J. Mushrush, Andrew P.-A. Karalewitz, John Schmitt, Joseph T. Barbieri, Benjamin W. Spiller, Desirée A. Benefield
Publikováno v:
Biochemistry. 49:5200-5205
Botulinum neurotoxin (BoNT) binds peripheral neurons at the neuromuscular junction through a dual-receptor mechanism that includes interactions with ganglioside and protein receptors. The receptor identities vary depending on BoNT serotype (A-G). BoN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3e8fe994aa3468f2c547fdd5b84637
https://doi.org/10.1021/bi100412v
https://doi.org/10.1021/bi100412v
Autor:
Morgan A. Sammons, Andrew J. Link, D. Borden Lacy, Hanane A. Koteiche, Hassane S. Mchaourab, Darren J. Mushrush
Botulinum neurotoxin (BoNT) belongs to a large class of toxic proteins that act by enzymatically modifying cytosolic substrates within eukaryotic cells. The process by which a catalytic moiety is transferred across a membrane to enter the cytosol is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb964f446511ce447788368bb4af648
https://europepmc.org/articles/PMC3143659/
https://europepmc.org/articles/PMC3143659/
Autor:
Ben Spiller, Darren J. Mushrush, Mark S. McClain, Timothy L. Cover, Kelly A. Gangwer, Devin L. Stauff, D. Borden Lacy
Helicobacter pylori VacA, a pore-forming toxin secreted by an autotransporter pathway, causes multiple alterations in human cells, contributes to the pathogenesis of peptic ulcer disease and gastric cancer, and is a candidate antigen for inclusion in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1d9611e419ef26121719f05b8b0544
https://europepmc.org/articles/PMC2042200/
https://europepmc.org/articles/PMC2042200/
Autor:
Schmitt, John, Andrew Karalewitz, Desire A. Benefield, Darren J. Mushrush, Rory N. Pruitt, Benjamin W. Spiller, Barbieri, Joseph T., Lacy, D. Borden
Publikováno v:
Biochemistry; 6/29/2010, Vol. 49 Issue 25, p5200-5205, 6p