Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Darren J, Mitchell"'
Autor:
Mohammed Ghiboub, Jan Koster, Peter D. Craggs, Andrew Y. F. Li Yim, Anthony Shillings, Sue Hutchinson, Ryan P. Bingham, Kelly Gatfield, Ishtu L. Hageman, Gang Yao, Heather P. O’Keefe, Aaron Coffin, Amish Patel, Lisa A. Sloan, Darren J. Mitchell, Thomas G. Hayhow, Laurent Lunven, Robert J. Watson, Christopher E. Blunt, Lee A. Harrison, Gordon Bruton, Umesh Kumar, Natalie Hamer, John R. Spaull, Danny A. Zwijnenburg, Olaf Welting, Theodorus B. M. Hakvoort, Anje A. te Velde, Johan van Limbergen, Peter Henneman, Rab K. Prinjha, Menno P. J. de Winther, Nicola R. Harker, David F. Tough, Wouter J. de Jonge
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-27 (2022)
Abstract Background SP140 is a bromodomain-containing protein expressed predominantly in immune cells. Genetic polymorphisms and epigenetic modifications in the SP140 locus have been linked to Crohn’s disease (CD), suggesting a role in inflammation
Externí odkaz:
https://doaj.org/article/9421aa4ae34c4942a0bffbd856768807
Autor:
Patricia F Medeiros, Mythily Vimal, Vipulkumar Kantibhai Patel, John Evans, Neil R Carlson, Antonia J. Lewis, Paul Bamborough, Katherine L Jones, Jane E Smith, Michael O'Sullivan, Scott McCleary, Darren J. Mitchell, Heather Barnett, Chun-wa Chung, Gang Yao, Anthony W. J. Cooper, Rab K. Prinjha, Laurie Gordon, Mahnoor Mahmood, Peter D. Craggs, Isobel L Harada, Rino A Bit, Natalie Wellaway, Armelle Le Gall, Robert J. Watson, Tony W Dean, Dominique Amans, Ian D. Wall, Kayleigh A J Stafford, Dave Lugo, Matthew J Lindon, Rishi R Shah, David Jonathan Hirst, Chris Patten, Darren L Poole, Jack A Brown, Philip G Humphreys, Robert P Davis, Christopher Roland Wellaway, Pamela J Thomas
Publikováno v:
Journal of Medicinal Chemistry. 63:714-746
The bromodomain and extraterminal (BET) family of bromodomain-containing proteins are important regulators of the epigenome through their ability to recognize N-acetyl lysine (KAc) post-translational modifications on histone tails. These interactions
Autor:
Lee A, Harrison, Stephen J, Atkinson, Anna, Bassil, Chun-Wa, Chung, Paola, Grandi, James R J, Gray, Etienne, Levernier, Antonia, Lewis, David, Lugo, Cassie, Messenger, Anne-Marie, Michon, Darren J, Mitchell, Alex, Preston, Rab K, Prinjha, Inmaculada, Rioja, Jonathan T, Seal, Simon, Taylor, Ian D, Wall, Robert J, Watson, James M, Woolven, Emmanuel H, Demont
Publikováno v:
Journal of medicinal chemistry. 64(15)
Domain-specific BET bromodomain ligands represent an attractive target for drug discovery with the potential to unlock the therapeutic benefits of antagonizing these proteins without eliciting the toxicological aspects seen with pan-BET inhibitors. W
Autor:
James M. Woolven, William J. Kerr, Chun-wa Chung, Bhumika Karamshi, Beata S. Wyspiańska, John Evans, Emmanuel Hubert Demont, Laurie Gordon, Matthew J Lindon, Peter E. Soden, Rob Willis, Leanne Cutler, Darren J. Mitchell, Christopher Roland Wellaway, Antonia J. Lewis, Robert J. Watson, Paul Bamborough, Simon Taylor, Inmaculada Rioja, Sharon G. Bernard, Rab K. Prinjha, Peter D. Craggs
The bromodomain and extraterminal domain (BET) family of epigenetic regulators comprises four proteins (BRD2, BRD3, BRD4, BRDT), each containing tandem bromodomains. To date, small molecule inhibitors of these proteins typically bind all eight bromod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2071ff9f599969eeda5e1e32f456446
https://strathprints.strath.ac.uk/73542/1/Wellaway_etal_JMC_2020_Structure_based_design_of_a_bromodomain_and_extraterminal_domain_BET_inhibitor.pdf
https://strathprints.strath.ac.uk/73542/1/Wellaway_etal_JMC_2020_Structure_based_design_of_a_bromodomain_and_extraterminal_domain_BET_inhibitor.pdf
Autor:
Alex, Preston, Stephen, Atkinson, Paul, Bamborough, Chun-Wa, Chung, Peter D, Craggs, Laurie, Gordon, Paola, Grandi, James R J, Gray, Emma J, Jones, Matthew, Lindon, Anne-Marie, Michon, Darren J, Mitchell, Rab K, Prinjha, Francesco, Rianjongdee, Inmaculada, Rioja, Jonathan, Seal, Simon, Taylor, Ian, Wall, Robert J, Watson, James, Woolven, Emmanuel H, Demont
Publikováno v:
Journal of medicinal chemistry. 63(17)
Pan-bromodomain and extra terminal domain (BET) inhibitors interact equipotently with the eight bromodomains of the BET family of proteins and have shown profound efficacy in a number of
Autor:
Paul Bamborough, Chun-wa Chung, RebeccaC. Furze, Paola Grandi, Anne-Marie Michon, Robert J. Sheppard, Heather Barnett, Hawa Diallo, DavidP. Dixon, Clement Douault, Emma J. Jones, Bhumika Karamshi, Darren J. Mitchell, Rab K. Prinjha, Christina Rau, RobertJ. Watson, Thilo Werner, Emmanuel H. Demont
Publikováno v:
Journal of Medicinal Chemistry; Aug2015, Vol. 58 Issue 15, p6151-6178, 28p
Autor:
Emmanuel H. Demont, Chun-wa Chung, RebeccaC. Furze, Paola Grandi, Anne-Marie Michon, Chris Wellaway, Nathalie Barrett, Angela M. Bridges, PeterD. Craggs, Hawa Diallo, David P. Dixon, Clement Douault, Amanda J. Emmons, EmmaJ. Jones, Bhumika V. Karamshi, Kelly Locke, Darren J. Mitchell, BernadetteH. Mouzon, Rab K. Prinjha, Andy D. Roberts
Publikováno v:
Journal of Medicinal Chemistry; Jul2015, Vol. 58 Issue 14, p5649-5673, 25p
Autor:
Susan M. Westaway, Samantha L. Brown, Stephen C. M. Fell, Christopher N. Johnson, David T. MacPherson, Darren J. Mitchell, James W. Myatt, Steven J. Stanway, Jon T. Seal, Geoffrey Stemp, Mervyn Thompson, Kirk Lawless, Fiona McKay, Alison I. Muir, Jonathan M. Barford, Chermaine Cluff, Sadhia R. Mahmood, Kim L. Matthews, Shiyam Mohamed, Beverley Smith
Publikováno v:
Journal of Medicinal Chemistry; Feb2009, Vol. 52 Issue 4, p1180-1189, 10p