Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Darren I, O'Brien"'
Autor:
Ewa M. Michalak, Lindsay C. Spender, Louise J. Clark, Gareth J. Inman, Mark S. Cragg, Jian Yu, Matthew J. Carter, Lina Happo, Darren I. O'Brien
Publikováno v:
The Journal of Biological Chemistry
Background: TGF-β induces apoptosis in Burkitt's lymphoma cells. Results: PUMA is a direct target gene of TGF-β signaling and is required for rapid apoptosis. Conclusion: TGF-β-mediated direct induction of PUMA contributes to apoptosis in human an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39eb6346de27bc80230cd84f3351e49a
https://doi.org/10.1074/jbc.m112.410274
https://doi.org/10.1074/jbc.m112.410274
Autor:
Max Patridge, Karin A. Oien, Reshma Shah, Nelofer Syed, Darren I. O'Brien, Louise Hiller, Clare Orange, Blanca Herrera, Paul Smith, Martino Monteverde, Milena Gasco, Francesca M. Buffa, Jelena Mann, Cristiana Lo Nigro, Meghan E. Maurer, Laura Lattanzio, Jonathan A. Cooper, Adrian L. Harris, Margaret C. Frame, Gabriela Kalna, Tim Crook, Linda J. Nicholson, Adele Hannigan, Lindsay C. Spender, David C. K. Chu, Catharine M L West, Johanna K. Thurlow, Gareth J. Inman
Publikováno v:
Hannigan, A, Smith, P, Kalna, G, Lo Nigro, C, Orange, C, O'Brien, D I, Shah, R, Syed, N, Spender, L C, Herrera, B, Thurlow, J K, Lattanzio, L, Monteverde, M, Maurer, M E, Buffa, F M, Mann, J, Chu, D C K, West, C M L, Patridge, M, Oien, K A, Cooper, J A, Frame, M C, Harris, A L, Hiller, L, Nicholson, L J, Gasco, M, Crook, T & Inman, G J 2010, ' Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter ', Journal of Clinical Investigation, vol. 120, no. 8, pp. 2842-57 . https://doi.org/10.1172/JCI36125
The cytokine TGF-beta acts as a tumor suppressor in normal epithelial cells and during the early stages of tumorigenesis. During malignant progression, cancer cells can switch their response to TGF-beta and use this cytokine as a potent oncogenic fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4710c43c622a563e0be8cceeaa0a9c
https://doi.org/10.1172/jci36125
https://doi.org/10.1172/jci36125
Autor:
Triona Goode, Fergus Shanahan, C. P. Bredin, Michael W. Bennett, Darren I. O'Brien, Terence M. O'Connor, Joe O'Connell, Louise M. Burke
Publikováno v:
Journal of Clinical Immunology. 23:425-435
Substance P (SP) is a proinflammatory neuropeptide that is secreted by sensory nerves and inflammatory cells. Increased levels of SP are found in sarcoid bronchoalveolar lavage fluid. SP acts by binding to the neurokinin-1 receptor and increases secr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c59d986d710ec9ef9ce3b3eeb3686d85
https://doi.org/10.1023/a:1025381803192
https://doi.org/10.1023/a:1025381803192
Publikováno v:
Annals of the New York Academy of Sciences. 973:161-165
This paper aims to examine the contribution of all three of the MAP kinase signaling pathways to Fas-induced IL-8 up-regulation in HT29 colon epithelial cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff4150a1fdff2e27c308c7f6a37c3aa
https://doi.org/10.1111/j.1749-6632.2002.tb04627.x
https://doi.org/10.1111/j.1749-6632.2002.tb04627.x
Autor:
Martin J. Allday, D. Simpson, Darren I. O'Brien, Gareth J. Inman, Louise J. Clark, D. Dutt, Christopher D. Gregory, Lindsay C. Spender
Publikováno v:
Spender, L C, O'Brien, D I, Simpson, D, Dutt, D, Gregory, C D, Allday, M J, Clark, L J & Inman, G J 2009, ' TGF-beta induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-XL ', Cell Death and Differentiation, vol. 16, no. 4, pp. 593-602 . https://doi.org/10.1038/cdd.2008.183
Cell death and differentiation
Cell death and differentiation
Transforming growth factor-beta (TGF-beta) potently induces apoptosis in Burkitt's lymphoma (BL) cell lines and in explanted primary human B lymphocytes. The physiological relevance and mechanism of TGF-beta-mediated apoptosis induction in these cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbf9f88812dfdb1a8130d1a7d155e8c
https://hdl.handle.net/20.500.11820/3d10e6f1-7cc7-4867-bad2-2419251a6103
https://hdl.handle.net/20.500.11820/3d10e6f1-7cc7-4867-bad2-2419251a6103
Autor:
Raymond Kelly, Fergus Shanahan, Kenneth Nally, Joe O'Connell, Terrence M O'Connor, Darren I. O'Brien
Publikováno v:
Expert opinion on therapeutic targets. 9(5)
Fas is a transmembrane receptor that can induce apoptosis after cross-linking with either agonistic antibodies or with Fas ligand (FasL). Although originally described as an important regulator of peripheral immune homeostasis, accumulating evidence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9541585e3392cb625aa35409615ebeb3
https://pubmed.ncbi.nlm.nih.gov/16185156
https://pubmed.ncbi.nlm.nih.gov/16185156
Autor:
Fergus Shanahan, C. P. Bredin, Joe O'Connell, Triona Goode, Darren I. O'Brien, Terence M. O'Connor
Publikováno v:
Journal of cellular physiology. 201(2)
The diffuse neuroendocrine system consists of specialised endocrine cells and peptidergic nerves and is present in all organs of the body. Substance P (SP) is secreted by nerves and inflammatory cells such as macrophages, eosinophils, lymphocytes, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974dfdf16f1ed969ec30260fa69f3637
https://pubmed.ncbi.nlm.nih.gov/15334652
https://pubmed.ncbi.nlm.nih.gov/15334652
Autor:
Terence M, O'Connor, Joseph, O'Connell, Darren I, O'Brien, Michael W, Bennett, Triona, Goode, Louise, Burke, Charles P, Bredin, Fergus, Shanahan
Publikováno v:
Journal of clinical immunology. 23(5)
Substance P (SP) is a proinflammatory neuropeptide that is secreted by sensory nerves and inflammatory cells. Increased levels of SP are found in sarcoid bronchoalveolar lavage fluid. SP acts by binding to the neurokinin-1 receptor and increases secr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d4f38e606870e4fa372ac48643fd697
https://pubmed.ncbi.nlm.nih.gov/14601651
https://pubmed.ncbi.nlm.nih.gov/14601651
Publikováno v:
Gastroenterology. 124:A158
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33eb9688141343599403b3afe8c23487
https://doi.org/10.1016/s0016-5085(03)80787-4
https://doi.org/10.1016/s0016-5085(03)80787-4