Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Darren Fayne"'
Autor:
Claudia Efstathiou, Yamei Zhang, Shubhangi Kandwal, Darren Fayne, Eleanor J. Molloy, Nigel J. Stevenson
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Human respiratory viruses are the most prevalent cause of disease in humans, with the highly infectious RSV being the leading cause of infant bronchiolitis and viral pneumonia. Responses to type I IFNs are the primary defense against viral infection.
Externí odkaz:
https://doaj.org/article/b29384ec21284855ba00cc2d05e8eb34
Publikováno v:
ACS Omega, Vol 8, Iss 42, Pp 39468-39480 (2023)
Externí odkaz:
https://doaj.org/article/2f8d5fdcdf344773a1b3619e1987ba17
Autor:
James P. McKeown, Andrew J. Byrne, Sandra A. Bright, Clara E. Charleton, Shubhangi Kandwal, Ivan Čmelo, Brendan Twamley, Anthony M. McElligott, Darren Fayne, Niamh M. O’Boyle, D. Clive Williams, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1034 (2024)
Chronic lymphocytic leukemia (CLL) is a malignancy of mature B cells, and it is the most frequent form of leukemia diagnosed in Western countries. It is characterized by the proliferation and accumulation of neoplastic B lymphocytes in the blood, lym
Externí odkaz:
https://doaj.org/article/ec8f4b69512c421787aea349de4351eb
Autor:
Andrew J. Byrne, Sandra A. Bright, James. P. McKeown, Adam Bergin, Brendan Twamley, Anthony M. McElligott, Sara Noorani, Shubhangi Kandwal, Darren Fayne, Niamh M. O’Boyle, D. Clive Williams, Mary J. Meegan
Publikováno v:
Molecules, Vol 28, Iss 24, p 8095 (2023)
Chronic lymphocytic leukaemia (CLL) is a malignancy of the immune B lymphocyte cells and is the most common leukaemia diagnosed in developed countries. In this paper, we report the synthesis and antiproliferative effects of a series of (E)-9-(2-nitro
Externí odkaz:
https://doaj.org/article/4eb2cf5d956c4622b0b26f06f0efdc53
Autor:
Shu Wang, Azizah M. Malebari, Thomas F. Greene, Shubhangi Kandwal, Darren Fayne, Seema M. Nathwani, Daniela M. Zisterer, Brendan Twamley, Niamh M. O’Boyle, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 1000 (2023)
A series of novel 3-(prop-1-en-2-yl)azetidin-2-one, 3-allylazetidin-2-one and 3-(buta-1,3-dien-1-yl)azetidin-2-one analogues of combretastatin A-4 (CA-4) were designed and synthesised as colchicine-binding site inhibitors (CBSI) in which the ethylene
Externí odkaz:
https://doaj.org/article/a88c634232124ff8893931a453eafe31
Autor:
Azizah M. Malebari, Gabriela Duffy Morales, Brendan Twamley, Darren Fayne, Mohemmed Faraz Khan, Eavan C. McLoughlin, Niamh M. O’Boyle, Daniela M. Zisterer, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1044 (2022)
The stilbene combretastatin A-4 (CA-4) is a potent microtubule-disrupting agent interacting at the colchicine-binding site of tubulin. In the present work, the synthesis, characterisation and mechanism of action of a series of 3-fluoro and 3,3-difluo
Externí odkaz:
https://doaj.org/article/ce1244d0e8b94117b595145343d4558c
Autor:
Azizah M. Malebari, Shu Wang, Thomas F. Greene, Niamh M. O’Boyle, Darren Fayne, Mohemmed Faraz Khan, Seema M. Nathwani, Brendan Twamley, Thomas McCabe, Daniela M. Zisterer, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1119 (2021)
Antimitotic drugs that target tubulin are among the most widely used chemotherapeutic agents; however, the development of multidrug resistance has limited their clinical activity. We report the synthesis and biological properties of a series of novel
Externí odkaz:
https://doaj.org/article/7f2b0031e7fb41bc8378c9286946a121
Autor:
Gloria Ana, Patrick M. Kelly, Azizah M. Malebari, Sara Noorani, Seema M. Nathwani, Brendan Twamley, Darren Fayne, Niamh M. O’Boyle, Daniela M. Zisterer, Elisangela Flavia Pimentel, Denise Coutinho Endringer, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 169 (2021)
We report the synthesis and biochemical evaluation of compounds that are designed as hybrids of the microtubule targeting benzophenone phenstatin and the aromatase inhibitor letrozole. A preliminary screening in estrogen receptor (ER)-positive MCF-7
Externí odkaz:
https://doaj.org/article/c41b78584775460886dc442b2b85cb34
Publikováno v:
Molecules, Vol 25, Iss 18, p 4065 (2020)
Based on the use of s-triazine as a scaffold, we report here a new series of s-triazine Schiff base derivatives and their anti-proliferative activity against two cancer cell lines: human breast carcinoma (MCF-7), and colon cancer (HCT-116) compared w
Externí odkaz:
https://doaj.org/article/340b4e6620a949b189872b6fd29fb086
Autor:
Andrew J. Byrne, Sandra A. Bright, James P. McKeown, John E. O’Brien, Brendan Twamley, Darren Fayne, D. Clive Williams, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 13, Iss 1, p 16 (2020)
Lymphomas (cancers of the lymphatic system) account for 12% of malignant diseases worldwide. Burkitt’s lymphoma (BL) is a rare form of non-Hodgkin’s lymphoma in which the cancer starts in the immune B-cells. We report the synthesis and preliminar
Externí odkaz:
https://doaj.org/article/e347fc61fc9f415796bc0140917546d5