Zobrazeno 1 - 10 of 69 pro vyhledávání: '"Darren Edwards"'
1
Akademický článek
Susceptibility of pediatric acute lymphoblastic leukemia to STAT3 inhibition depends on p53 induction
Autor: Luca Gasparoli, Clemence Virely, Alexia Tsakaneli, Noelia Che, Darren Edwards, Jack Bartram, Michael Hubank, Deepali Pal, Olaf Heidenreich, Joost H.A. Martens, Jasper de Boer, Owen Williams
Publikováno v: Haematologica, Vol 109, Iss 4 (2023)
Advances in the clinical management of pediatric B-cell acute lymphoblastic leukemia (B-ALL) have dramatically improved outcomes for this disease. However, relapsed and high-risk disease still contribute to significant numbers of treatment failures.
Externí odkaz: https://doaj.org/article/aa3599b620044cacb18115d1719e17ca
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4
Akademický článek
Establishment and phenotyping of neurosphere cultures from primary neuroblastoma samples [version 1; peer review: 3 approved]
Autor: Jack Barton, Katherine Pacey, Neha Jain, Tessa Kasia, Darren Edwards, Christine Thevanesan, Karin Straathof, Giuseppe Barone, John Anderson
Publikováno v: F1000Research, Vol 8 (2019)
Background: Primary cell culture using serum free media supplemented with growth factors has been used in a number of cancers to propagate primary cells with stem like properties, which form as spherical cellular aggregates. Methods: We systematicall
Externí odkaz: https://doaj.org/article/d5704da54a7846139c1435a460cecb63
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6
Functional contextual implementation of an evolutionary, entropy-based, and embodied free energy framework: Utilizing Lagrangian mechanics and evolutionary game theory’s truth vs. fitness test of the veridicality of phenomenological experience
Autor: Darren Edwards
Publikováno v: Frontiers in Psychology. 14
The Bayesian approach of cognitive science largely takes the position that evolution drives perception to produce precepts that are veridical. However, some efforts utilizing evolutionary game theory simulations have shown that perception is more lik
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7492e71609e9c0c9fbdbf9f03f3ed0ee
https://doi.org/10.3389/fpsyg.2023.1150743
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8
Going beyond the DSM in predicting, diagnosing, and treating autism spectrum disorder with covarying alexithymia and OCD: A structural equation model and process-based predictive coding account
Autor: Darren Edwards
Publikováno v: Frontiers in Psychology. 13
BackgroundThere is much overlap among the symptomology of autistic spectrum disorders (ASDs), obsessive compulsive disorders (OCDs), and alexithymia, which all typically involve impaired social interactions, repetitive impulsive behaviors, problems w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c869606f8993d19f80165cfd8cce25b6
https://doi.org/10.3389/fpsyg.2022.993381
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10
High-Throughput Screening Platform To Identify Inhibitors of Protein Synthesis with Potential for the Treatment of Malaria
Autor: Fabio Tamaki, Fabio Fisher, Rachel Milne, Fernando Sánchez-Román Terán, Natalie Wiedemar, Karolina Wrobel, Darren Edwards, Hella Baumann, Ian H. Gilbert, Beatriz Baragana, Jake Baum, Susan Wyllie
Publikováno v: Antimicrobial agents and chemotherapy. 66(6)
Artemisinin-based combination therapies have been crucial in driving down the global burden of malaria, the world's largest parasitic killer. However, their efficacy is now threatened by the emergence of resistance in Southeast Asia and sub-Saharan A
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08b9491e3f15954e2a8a01b4aa101ed
https://pubmed.ncbi.nlm.nih.gov/35647647
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