Zobrazeno 1 - 10
of 9 709
pro vyhledávání: '"Darren D"'
Autor:
Margherita Bertuzzi, Gareth J. Howell, Darren D. Thomson, Rachael Fortune-Grant, Anna Möslinger, Patrick Dancer, Norman Van Rhijn, Natasha Motsi, Alice Codling, Elaine M. Bignell
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109939- (2024)
Summary: Hundreds of spores of Aspergillus fumigatus (Af) are inhaled daily by human beings, representing a constant, possibly fatal, threat to respiratory health. The small size of Af spores suggests that interactions with alveolar epithelial cells
Externí odkaz:
https://doaj.org/article/ff7b9b1ee6e3455b85a6661245bccc68
Autor:
Beibei Zhao, Catherine M. Cowan, Juliane A. Coutts, Darren D. Christy, Ananya Saraph, Shawn C. C. Hsueh, Stephen S. Plotkin, Ian R. Mackenzie, Johanne M. Kaplan, Neil R. Cashman
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract TAR DNA-binding protein 43 (TDP-43) and Fused in Sarcoma/Translocated in Sarcoma (FUS) are ribonucleoproteins associated with pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Under physiologic
Externí odkaz:
https://doaj.org/article/1d6e11bc4ae24e4888e214787663cda9
Autor:
Vanessa I. Francis, Corin Liddle, Emma Camacho, Madhura Kulkarni, Samuel R. S. Junior, Jamie A. Harvey, Elizabeth R. Ballou, Darren D. Thomson, Gordon D. Brown, J. Marie Hardwick, Arturo Casadevall, Jonathan Witton, Carolina Coelho
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTCryptococcus neoformans causes lethal meningitis and accounts for approximately 10%–15% of AIDS-associated deaths worldwide. There are major gaps in our understanding of how this fungus invades the mammalian brain. To investigate the dynami
Externí odkaz:
https://doaj.org/article/fc389f2ba9944567b613ee2209d651cc
Publikováno v:
European Physical Journal C: Particles and Fields, Vol 83, Iss 10, Pp 1-21 (2023)
Abstract There is no known reason that dark matter interactions with the Standard Model should couple to neutrons and protons in the same way. This isospin violation can have large consequences, modifying the sensitivity of existing and future direct
Externí odkaz:
https://doaj.org/article/dce01df933ff4577ba89a3d1eefe6e51
Autor:
Flavia O. S. van Cleef, José C. B. Dubeux, Francine M. Ciriaco, Darren D. Henry, Martin Ruiz-Moreno, David M. Jaramillo, Liza Garcia, Erick R. S. Santos, Nicolas DiLorenzo, João M. B. Vendramini, Harley D. Naumann, Lynn E. Sollenberger
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The objectives of this study were to determine the emission of nitrous oxide (N2O), methane (CH4), and carbon dioxide (CO2), as well as the isotopic composition of N2O from excreta of beef steers fed ‘AU Grazer’ sericea lespedeza hay [SL
Externí odkaz:
https://doaj.org/article/8d75c72890a348cca4462f4b42041076
Autor:
Sayema Rahman, Norman van Rhijn, Panagiotis Papastamoulis, Darren D. Thomson, Zorana Carter, Rachael Fortune-Grant, Magnus Rattray, Michael John Bromley, Elaine Bignell
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Damage to the lung epithelium is a unifying feature of disease caused by the saprophytic fungus Aspergillus fumigatus. However, the mechanistic basis and the regulatory control of such damage is poorly characterized. Previous studies have identified
Externí odkaz:
https://doaj.org/article/e35ba8913ed0458ab3948445b0b9f1ce
Autor:
Avelina Lee, Iryna Lebedyeva, Wenbo Zhi, Vani Senthil, Herjot Cheema, Michael W. Brands, Weston Bush, Nevin A. Lambert, Madeline Snipes, Darren D. Browning
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9397 (2023)
Phosphodiesterase-5 inhibitors (PDE5i) are under investigation for repurposing for colon cancer prevention. A drawback to conventional PDE5i are their side-effects and drug–drug interactions. We designed an analog of the prototypical PDE5i sildenaf
Externí odkaz:
https://doaj.org/article/471889a64ff54b16a615cdad5c2b6495
Autor:
Hosneara Akter, Mohammad Shahnoor Hossain, Nushrat Jahan Dity, Md. Atikur Rahaman, K. M. Furkan Uddin, Nasna Nassir, Ghausia Begum, Reem Abdel Hameid, Muhammad Sougatul Islam, Tahrima Arman Tusty, Mohammad Basiruzzaman, Shaoli Sarkar, Mazharul Islam, Sharmin Jahan, Elaine T. Lim, Marc Woodbury-Smith, Dimitri James Stavropoulos, Darren D. O’Rielly, Bakhrom K. Berdeiv, A. H. M. Nurun Nabi, Mohammed Nazmul Ahsan, Stephen W. Scherer, Mohammed Uddin
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Collectively, rare genetic diseases affect a significant number of individuals worldwide. In this study, we have conducted whole-exome sequencing (WES) and identified underlying pathogenic or likely pathogenic variants in five children with
Externí odkaz:
https://doaj.org/article/be7577baefe0449d9e32b34e4247a672
Autor:
Sara Rahmati, Darren D. O’Rielly, Quan Li, Dianne Codner, Amanda Dohey, Kari Jenkins, Igor Jurisica, Dafna D. Gladman, Vinod Chandran, Proton Rahman
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Biological therapies have dramatically improved the therapeutic landscape of psoriatic arthritis (PsA); however, 40–50% of patients are primary non-responders with response rates declining significantly with each successive biological ther
Externí odkaz:
https://doaj.org/article/89afa7b431d842f397da1b39a9b64a04
Autor:
Kristina H Lewis, Ming Ji, Karen J Coleman, Silvia R Paz, Bhumi B Bhakta, Brianna Taylor, Jialuo Liu, Tae K Yoon, Mayra Macias, David E Arterburn, Cecelia L Crawford, Adam Drewnowksi, Marlaine S Figueroa Gray, Laurel D Hansell, Darren D Moore, Sameer B Murali, Deborah R Young
Publikováno v:
BMJ Open, Vol 12, Iss 5 (2022)
Purpose The Bariatric Experience Long Term (BELONG) prospective study cohort was created to address limitations in the literature regarding the relationship between surgical weight loss and psychosocial, health, behaviour and environmental factors. T
Externí odkaz:
https://doaj.org/article/89473e9e474648f1b2618ed4ce26bdb5