Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Darren Cuthbert-Heavens"'
Autor:
Darren Cuthbert-Heavens, Chris J. Groves, Shirley Hodgson, Robin K. S. Phillips, Sylvia Bass, Jill Williamson, Ian Tomlinson, Claire Taylor, Michael Crabtree, H. Lamlum
Studies of adenomatous polyposis coli (APC) mutations in familial adenomatous polyposis (FAP) have focused on large bowel disease. It has been found that: 1) germline APC mutations around codon 1300 are associated with severe colorectal polyposis; 2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565b8dd808f7b2a1581d80c5ed8307be
https://ora.ox.ac.uk/objects/uuid:a77ae563-c8f8-4488-b616-62b05f75d231
https://ora.ox.ac.uk/objects/uuid:a77ae563-c8f8-4488-b616-62b05f75d231
Publikováno v:
Oncogene. 21:809-824
The mechanism of bFGF-induced cell death in tumours of the Ewing's sarcoma family (ESFT) has been investigated. bFGF-induces phosphorylation of FGFr 1 and activation of Ras/ERK in ESFT cells that die when exposed to bFGF. Induction of cell death was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9087d83621d650e12b6e1d53412608e4
https://doi.org/10.1038/sj.onc.1205128
https://doi.org/10.1038/sj.onc.1205128
Publikováno v:
Oncogene. 20:686-691
4p16.3 has previously been identified as a region of non-random LOH in transitional cell carcinoma, suggesting the presence of a tumour suppressor gene. One candidate within this region is fibroblast growth factor receptor 3 (FGFR3). Germline mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84bdb4acedcde47eb8196913db153d8
https://doi.org/10.1038/sj.onc.1204110
https://doi.org/10.1038/sj.onc.1204110
Autor:
M. Calaminici, Lindsey K. Goff, Claire Taylor, Darren Cuthbert-Heavens, Andrew Davies, Jude Fitzgibbon, Andrew J. Norton, Sameena Iqbal, T. A. Lister, Abigail M. Lee, Andrew Clear
Publikováno v:
Leukemia. 19(8)
The role of TP53 mutation in transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (t-FL) was examined in a panel of 91 lymph node biopsies derived from 29 patients pre- and post-transformation. The entire TP53 coding sequence w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1109b076395bbae0d183bb4eae5d5fa4
https://pubmed.ncbi.nlm.nih.gov/15902285
https://pubmed.ncbi.nlm.nih.gov/15902285
Publikováno v:
Cancer research. 63(22)
Deletions of the long arm of chromosome 9 are the most common genetic alteration in transitional cell carcinoma (TCC) of the bladder. Several regions of deletion on 9q have been mapped by loss of heterozygosity (LOH) analysis, one of which encompasse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a5936a3216cf81cad5637eef6b65d77
https://pubmed.ncbi.nlm.nih.gov/14633685
https://pubmed.ncbi.nlm.nih.gov/14633685
Autor:
Janice Rowe, Darren Cuthbert-Heavens, Sarah Drayton, Gordon Peters, Rebecca Jones, Mike Fried, Radost Vatcheva, John Marshall
Publikováno v:
Cancer cell. 4(4)
The Ink4a/Arf locus encodes two distinct proteins, both of which may contribute to senescence and tumor suppression. We find that human diploid fibroblasts (HDFs) that are specifically deficient for p16INK4a achieve anchorage independence when transd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0caa77d7bd65632a4e824d4f97f0236
https://pubmed.ncbi.nlm.nih.gov/14585357
https://pubmed.ncbi.nlm.nih.gov/14585357
Autor:
D. Timothy Bishop, Juliette Randerson-Moor, Joanne S. Aveyard, Margaret A. Knowles, Darren Cuthbert-Heavens, Kathryn Sibley, Eamonn Sheridan, Sarah V. Williams, Linda Whitaker, Mark Harland, Julia A. Newton Bishop
Publikováno v:
Human molecular genetics. 10(1)
The melanoma-astrocytoma syndrome is characterized by a dual predisposition to melanoma and neural system tumours, commonly astrocytoma. Germline deletions of the region on 9p21 containing the CDKN2A and CDKN2B genes and CDKN2A exon 1beta have been r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060b348c07cfe167d2fa2f316cc815fa
https://pubmed.ncbi.nlm.nih.gov/11136714
https://pubmed.ncbi.nlm.nih.gov/11136714