Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Darren Cross"'
Autor:
Sally J. Adua, Anna Arnal-Estapé, Minghui Zhao, Bowen Qi, Zongzhi Z. Liu, Carolyn Kravitz, Heather Hulme, Nicole Strittmatter, Francesc López-Giráldez, Sampada Chande, Alexandra E. Albert, Mary-Ann Melnick, Bomiao Hu, Katerina Politi, Veronica Chiang, Nicola Colclough, Richard J. A. Goodwin, Darren Cross, Paul Smith, Don X. Nguyen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
While EGFR-targeted therapies have clinical benefit, drug-resistant brain metastases present a major obstacle. Here, the authors identify a genetic signature in brain metastatic lesions associated with osimertinib resistance and find RhoA to have an
Externí odkaz:
https://doaj.org/article/3190ed6c2b6648c6bd0e559653995e8f
Autor:
Martin Pass, Donald Ogilvie, Richard Luke, Rebecca Watson, Clare Lane, James Yates, Ken Page, Christine C. Chresta, Sabina Cosulich, Darren Cross, Sally-Ann Ricketts, Juliana Maynard, Qunsheng Ji, Beirong Gao, Jing Li, Jingchuan Zhang, De-Hua Yu, Claire Crafter, Phillippa Dudley, Hannah Greenwood, Barry R. Davies
PDF file - 73K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9ea91e81a67f3f040a1bb9626f1a13
https://doi.org/10.1158/1535-7163.22498635
https://doi.org/10.1158/1535-7163.22498635
Autor:
Martin Pass, Donald Ogilvie, Richard Luke, Rebecca Watson, Clare Lane, James Yates, Ken Page, Christine C. Chresta, Sabina Cosulich, Darren Cross, Sally-Ann Ricketts, Juliana Maynard, Qunsheng Ji, Beirong Gao, Jing Li, Jingchuan Zhang, De-Hua Yu, Claire Crafter, Phillippa Dudley, Hannah Greenwood, Barry R. Davies
PDF file - 84K, Correlation of AZD5363 activity in cell lines from different tumor types with RAS, PIK3CA and PTEN status.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26adbc826f9cc85329a52ca84cf29cd2
https://doi.org/10.1158/1535-7163.22498644.v1
https://doi.org/10.1158/1535-7163.22498644.v1
Autor:
Martin Pass, Donald Ogilvie, Richard Luke, Rebecca Watson, Clare Lane, James Yates, Ken Page, Christine C. Chresta, Sabina Cosulich, Darren Cross, Sally-Ann Ricketts, Juliana Maynard, Qunsheng Ji, Beirong Gao, Jing Li, Jingchuan Zhang, De-Hua Yu, Claire Crafter, Phillippa Dudley, Hannah Greenwood, Barry R. Davies
PDF file - 81K, Correlation of AZD5363 activity in cell lines from different tumor types with PIK3CA and PTEN mutation status.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58aca16ca8976daf5767839bc44394ac
https://doi.org/10.1158/1535-7163.22498647
https://doi.org/10.1158/1535-7163.22498647
Autor:
Carlos L. Arteaga, Jens Meiler, Christine M. Lovly, Darren Cross, Alshad S. Lalani, Richard E. Cutler, Vincent Miller, Jie He, David B. Solit, David M. Hyman, Michael F. Berger, Richard Lanman, Rebecca Nagy, Gregory R. Sliwoski, James P. Koch, Jonathan H. Sheehan, Monica Red Brewer, Ariella B. Hanker
Supplementary Figure S1. HER2L869R and HER3E928G cooperate to drive ERBB signaling output. Supplementary Figure S2. MG132 treatment restores expression of HER2T798I.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154dda147285a5c156d4cbf8d35fdb31
https://doi.org/10.1158/2159-8290.22531999.v1
https://doi.org/10.1158/2159-8290.22531999.v1
Autor:
Martin Pass, Donald Ogilvie, Richard Luke, Rebecca Watson, Clare Lane, James Yates, Ken Page, Christine C. Chresta, Sabina Cosulich, Darren Cross, Sally-Ann Ricketts, Juliana Maynard, Qunsheng Ji, Beirong Gao, Jing Li, Jingchuan Zhang, De-Hua Yu, Claire Crafter, Phillippa Dudley, Hannah Greenwood, Barry R. Davies
PDF file - 88K, Quantification of cleaved caspase 3 activity in HCC-1187 xenografts following chronic dosing with 5 mg/kg once weekly docetaxel (taxotere), 150 mg/kg bid AZD5363, or a combination of these two agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3112b5ae732cb14b1fb9210be4bf92
https://doi.org/10.1158/1535-7163.22498638.v1
https://doi.org/10.1158/1535-7163.22498638.v1
Autor:
Martin Pass, Donald Ogilvie, Richard Luke, Rebecca Watson, Clare Lane, James Yates, Ken Page, Christine C. Chresta, Sabina Cosulich, Darren Cross, Sally-Ann Ricketts, Juliana Maynard, Qunsheng Ji, Beirong Gao, Jing Li, Jingchuan Zhang, De-Hua Yu, Claire Crafter, Phillippa Dudley, Hannah Greenwood, Barry R. Davies
PDF file - 139K, AZD5363 has a predominantly anti-proliferative mechanism of action but induces cell death in BT474c, LNCaP and PC346C-Flut1 cells in vitro, and in BT474c xenografts following a high, intermittent dosing schedule in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59eda9af138e0854ae982cf0930bd6d1
https://doi.org/10.1158/1535-7163.22498641
https://doi.org/10.1158/1535-7163.22498641
Autor:
Martin Pass, Donald Ogilvie, Richard Luke, Rebecca Watson, Clare Lane, James Yates, Ken Page, Christine C. Chresta, Sabina Cosulich, Darren Cross, Sally-Ann Ricketts, Juliana Maynard, Qunsheng Ji, Beirong Gao, Jing Li, Jingchuan Zhang, De-Hua Yu, Claire Crafter, Phillippa Dudley, Hannah Greenwood, Barry R. Davies
PDF file - 117K, AZD5363 inhibits S6 phosphorylation in TSC1 -/-, TSC2 low-expressing RT4 bladder cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0694b929ca9bbf6674a0e14b9be57b20
https://doi.org/10.1158/1535-7163.22498650.v1
https://doi.org/10.1158/1535-7163.22498650.v1
Autor:
Carlos L. Arteaga, Jens Meiler, Christine M. Lovly, Darren Cross, Alshad S. Lalani, Richard E. Cutler, Vincent Miller, Jie He, David B. Solit, David M. Hyman, Michael F. Berger, Richard Lanman, Rebecca Nagy, Gregory R. Sliwoski, James P. Koch, Jonathan H. Sheehan, Monica Red Brewer, Ariella B. Hanker
Supplementary Table S1. Summary of mutations identified by FoundationOne profiling of the original, pre-neratinib skin metastasis. Supplementary Table S2. Frequency of HER2L869R and HER2T798I mutations. Supplementary Table S3. Sequencing of plasma DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f218f8081ab31c8a70d37c3929898c2
https://doi.org/10.1158/2159-8290.22531996.v1
https://doi.org/10.1158/2159-8290.22531996.v1
Autor:
Peter Ballard, Steve J. Powell, Martine J. Mellor, Darren Cross, Susan Ashton, James W.T. Yates
Full model description and Supplementary Table 1: Parameter estimates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c24d4a401f46950ecccf74cff495ff
https://doi.org/10.1158/1535-7163.22503823.v1
https://doi.org/10.1158/1535-7163.22503823.v1