Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Darren Caine"'
Autor:
Duguay, Darren Caine
Sepsis and its manifestation as a shock state in “septic shock” have long caused medical issues and death worldwide. The disease requires quick identification, diagnosis, and intervention with very high mortality rates prevalent otherwise. Histor
Externí odkaz:
https://hdl.handle.net/2144/36352
Autor:
Alan Millar, Claire Crawford, Sandeep B. Kedia, Bobby N. Glover, Jeremiah D. Powers, Christopher J. Nichols, Malcolm B. Berry, Mark B. Mitchell, Michael S. McClure, Brian C. Crump, Daniel E. Patterson, Darren Caine
Publikováno v:
European Journal of Organic Chemistry. 2012:3561-3565
A highly selective method for the alkoxycarboxylation and acylation of primary alcohols of pyranose derivatives is described. The reaction is high yielding and proceeds under mild conditions with 0.15–1 mol-% Sc(OTf)3 used in combination with anhyd
Publikováno v:
Organic Process Research & Development. 16:518-523
The sequential treatment of an intermediate in the synthesis of GSK159797 with a protic acid and sodium chloride was developed to control the stoichiometry of the hydrochloric acid salt of the API....
Autor:
Guillaume Roux, Fiona Rawlinson, Alcide Perboni, Michael Anthony Forth, Darren Caine, Adam Banks, Christopher Drake, Matthew E. Popkin, Jerome F. Hayes, John S. Carey, Asa Gladwin, Paolo Maragni, Gary F. Breen, David O. Morgan, Paul Oxley, Simone Guelfi
Publikováno v:
Organic Process Research & Development. 13:1130-1140
A synthetic route amenable to large-scale synthesis of the glycine antagonist (2R,4E)-7-chloro-4-(2-oxo-1-phenyl-pyyrrolidin-3-ylidene)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid, (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-penta-ol 12 is presen
Publikováno v:
Tetrahedron. 59:9779-9791
A detailed study of the rearrangement of five cycloalkene N -toluenesulfonyl (tosyl) aziridines using sec -butyllithium (with and without added ligands such as (−)-sparteine and TMEDA) has been carried out. Allylic sulfonamides were the main produc
Autor:
Peter W. Scott, Åsa Sjolin, Ron M. Lawrence, Jason W. B. Cooke, Roger Barrett, Darren Caine, Kevin S. Cardwell
Publikováno v:
Tetrahedron: Asymmetry. 14:3627-3631
A convenient, efficient and cost-effective two-stage synthesis of benzyl (3R)-3-amino-2-oxo-1-pyrrolidinecarboxylate (2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]butanediote (2:1) via a crystallisation-induced dynamic resolution process is reported.
Publikováno v:
Organic Letters. 4:1923-1926
[reaction: see text] The synthesis of novel substituted meso-aziridines is described: aziridination of 4-tert-butyldiphenylsilyloxy-cyclopent-1-ene is trans selective using Cu(I)/PhI=NSO(2)Ar and cis selective using PhNMe(3)(+)Br(3)(-)/Chloramine-T.
Publikováno v:
Tetrahedron Letters. 44:6613-6615
The α-lithiation rearrangement of three cyclic N -toluenesulfonyl (tosyl) aziridines has been carried out using sec -butyllithium/(−)-sparteine. In each case, it was established that preferential lithiation of the S -aziridine stereocentre occurre
Autor:
Darren Caine, Sandeep B. Kedia, Mark B. Mitchell, Bobby N. Glover, Christopher J. Nichols, Jeremiah D. Powers, Brian C. Crump, Daniel E. Patterson, Malcolm B. Berry, Michael S. McClure, Alan Millar, Claire Crawford
Publikováno v:
European Journal of Organic Chemistry. 2012
Publikováno v:
ChemInform. 33
The synthesis of novel substituted meso-aziridines is described: aziridination of 4-tert-butyldiphenylsilyloxy-cyclopent-1-ene is trans selective using Cu(I)/PhINSO2Ar and cis selective using PhNM...